Bachground: Cholelithiasis is one of the most common disorders of the digestive tract encountered bygeneral surgeons worldwide. Conventional or open cholecystectomy was the mainstay of treatment for a longtime for this disease. Laparoscopic cholecystectomy (LC) has been the gold standard for removal of thegallbladder since the early 1990s. Single-incision laparoscopic surgery is becoming a more widely acceptedsurgical approach. However, the feasibility and safety of single-incision laparoscopic cholecystectomy (SILC)are yet to be established. The present study compared outcomes following the use of SILC or conventionallaparoscopic cholecystectomy (CLC) on patients with gallbladder disease.Aim: To compare the perioperativeresults of single port laparoscopic cholecystectomy with the standard 4-port technique.Subjects and methods:The study involved 72 symptomatic gallbladder disease patients underwent laparoscopic cholecystectomy inZagazig University hospital.36 patients underwent SILC, and 36 patients underwent CLC. Clinical and surgicaloutcomes were compared.Results: The SILC and CLC groups were similar in terms of age, gender ratio, bodymass index, and diagnoses. The two groups were also found to be similar in terms of postoperative clinicalcourse and complications. The SILC group had a longer operation time, less postoperative pain, and a shorterhospital stay with better aesthetic results than the CLC group.Conclusion: SILC was as safe and feasible asCLC. The operating time was longer otherwise it has almost similar clinical outcomes to those of CLC.Keywords: Four port technique, Laparoscopic surgery, Single port surgery