Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
23
1
2017
01
01
PULMONARY COMPLICATIONS OTHER THAN TUBERCULOSIS IN HIV PATIENTS IN MANSOURA FEVER HOSPITAL.
1
4
EN
Ahmed
Elmorsy
Chest Medicine departments, Faculty of Medicine - Mansoura University - Egypt
Mohamed
Zaghloul
Clinical Pathology departments, Faculty of Medicine - Mansoura University - Egypt
Nessrin
Shalaby
Chest Medicine departments, Faculty of Medicine - Mansoura University - Egypt
Asem
Hewidy
Chest Medicine departments, Faculty of Medicine - Mansoura University - Egypt
Heba
El-shahawy
Clinical Patholog departments, Faculty of Medicine - Mansoura University - Egypt
Nagwa
Elhalawany
Chest Medicine departments, Faculty of Medicine - Mansoura University - Egypt
10.21608/zumj.2017.4677
Background: A remarkable cluster of Pneumocystis carinii pneumonia and Kaposi's sarcoma male cases with history of homosexuality first described in 1981, since that period fundamental improvement in understanding this acquired immune deficiency syndrome (AIDS) have been carried out [1].<br />Aim: The aim of this study was to evaluate the pulmonary complications in patients with HIV. Patients and Methods: A descriptive study conducted on 200 seropositive HIV adult patients screened for chest problems; 76 patients of them were included, and then TB infection has been excluded in 53 patients (70%). Results: Acute bronchitis (36%), community acquired pneumonia (CAP) (24%), chronic obstructive airway diseases (15%) and infective endocarditis (8%) in addition to malignancy were the manifested complications in those patients. Conclusion: HIV patients with advanced immune suppression are vulnerable group for chest complications from acute bronchitis to malignancy.
HIV,human immune deficiency virus, TB,tuberculosis, CAP,Community Acquired Pneumonia
https://zumj.journals.ekb.eg/article_4677.html
https://zumj.journals.ekb.eg/article_4677_4a95ddc7da378a0cea887ce6bc1f5264.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
23
1
2017
01
01
THE EFFECT OF METFORMIN ON MARKERS OF BONE METABOLISM IN MALE PATIENTS WITH TYPE 2 DIABETES MELLITUS
1
6
EN
Fayez
Mohamed
Internal Medicine Department, Faculty of Medicine, Mansoura University.
Fathy
Abdelgawad
Medical biochemistry department, Faculty of Medicine, Al-Azhar University
Tamer
Saber
Internal Medicine Department, Faculty of Medicine, Zagazig University
Ahmad
Ibrahim
Rheumatology Department, Faculty of Medicine, Benha University.
10.21608/zumj.2017.4678
Background: Bone is a vital, dynamic connective tissue that throughout life is continuously remodeled by balanced bone formation and resorption. It has been reported that diabetes and its metabolic disturbances and medications lead to important alterations in bone metabolism. The objective of this study is to determine the effect of metformin on markers of bone metabolism [N-terminal cross-linked telopeptide of type-1 collagen (NTx) and osteocalcin] in male patients with type 2 diabetes mellitus. Methods: a case-controlled study was conducted on 100 male type 2 diabetic patients. Their ages ranged from (35–50years) living in Saudi Arabia at Al-Madinah Al- Monawara Province. They were on oral antidiabetic drugs, divided into two groups according to treatment with metformin. Routine laboratory measurements included serum levels of fasting glucose, HbA1c, total calcium, inorganic phosphorus, total alkaline phosphatase and intact parathyroid hormone, osteocalcin was measured as a bone formation marker. Second-morning void urine was collected from patients to measure urinary NTx as a resorptive marker. Results: there was no significant difference between the two groups as regard the clinical, biochemical and diabetic control parameters(age, BMI, duration of diabetes, FBS, HbA1c, calcium, Phosphorus, total alkaline phosphatase, and iPTH). No statistical differences in osteocalcin (ng/ml) between the two groups (13.3±1.43 vs 13.0±1.4, P-value =0.348). The mean of NTx (nM BCE/mM creatinine) of metformin group 1 was (29.6±7.8) lower than that of non-metformin group 2 (44.6±6.1) with highly significant differences between the two groups (P=0.000).Conclusion: metformin may have a favorable effect on bone metabolism in type 2 diabetic males through a decrease of bone resorption marker, but more researches are required to know the overall impact of this medication on bone health on the long term.
Type2diabetes,Metformin,Bone turnover markers,Osteoporosis
https://zumj.journals.ekb.eg/article_4678.html
https://zumj.journals.ekb.eg/article_4678_ca335468f6db46cb54e8853544ae3c5d.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
23
1
2017
01
01
EFFECT OF HIGH DOSE METHOTREXATE AND DELAYED ELIMINATION ON MYELOTOXICITY PROGRESSION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
1
8
EN
Omar
El-Azzazy
Department of Pharmacy Practice , Faculty of Pharmacy , Zagazig University, Zagazig, Egypt
Manar
Fathy
Pediartic oncology unit ,Faculty of Medicine, Zagazig University, Zagazig, Egypt
Usama
El-Safy
Department of oncology of Faculty of Medicine, Zagazig University, Zagazig, Egypt
Hassan
El Fayoumi
Department of Pharmacology Faculty of Pharmacy,Zagazig University, Zagazig, Egypt
10.21608/zumj.2017.4679
Background: Methotrexate (MTX) as an antineoplastic agent inhibits dihydrofolate reductase. The frequency of high dose methotrexate (HDMTX) associated toxicity is variable. In this study we investigate the frequency of myelosuppression following 5 and 9 days of HDMTX infusion and MTX delayed elimination in subsequent MTX cycles in children with Acute lymphoblastic Leukemia (ALL).<br />Methods: This study included 28 children diagnosed with ALLduring the period between May2014to April 2016. Complete blood counts were measured before and after 5 and 9 days of HDMTX infusion and MTX levels at 42hour in 28 children with ALL. The HD-MTX dose is 5 gm/m2 during 102 infusion of HD MTX at consolidation phase of ALL therapy. The MTX levels at 42 h in patients with and without toxicity were compared to evaluate the correlation between MTX levels and myelotoxicity.<br />Results: MTX infusion induced significant reduction in levels of TLC, ANC, RBCs, Hb and significant elevation of PLT count after 5 days of MTX administration. Additionally, after 9 days of MTX infusion, there is significant decrease inTLC, ANC, and RBCs levels. However, no significant difference in the PLT count and Hb level occurred. There is gradual decrease in myelotoxicity after 5 days and increase after 9 days of MTX administration with regard to MTX cycles. There is no statistical difference in MTX level at 42 h between patients with and without myelotoxicity after 5 and 9 days of MTX infusion. MTX delayed elimination observed in MTX cycles 1, 2, 3 and 4 was 42.8% (n=12), 42.8% (n=12), 57.1% (n=16) and 72% (n=13) respectively.<br />Conclusion: Myelotoxicity was decreased after 5 days of MTX administration and increased after 9 days with regard to MTX cycles. There is no correlation between MTX plasma concentration after 42 h and hematologic toxicity. Therefore, we cannot depend on MTX levels at 42 h to anticipate and predict hematologic toxicity.
HDMTX,ALL,myelosupression,Blood count
https://zumj.journals.ekb.eg/article_4679.html
https://zumj.journals.ekb.eg/article_4679_ed1edd46079b9744f8e4834d02ddd3fb.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
23
1
2017
01
01
STUDY OF RELATIONSHIP BETWEEN SP1 POLYMORPHISM IN THE COLLAGEN TYPE I ALPHA -1 (COLIA1) GENE AND OSTEOPROSIS IN PATIENTS WITH BETA-THALASSEMIA.
1
13
EN
Naglaa
Khalifa
Clinical Pathology and pediatrics Medicine Departments, Faculty of Medicine, Zagazig University; Egypt.
Mervat
Hesham
Clinical Pathology and pediatrics Medicine Departments, Faculty of Medicine, Zagazig University; Egypt.
Nadia
Elbaz
Clinical Pathology and pediatrics Medicine Departments, Faculty of Medicine, Zagazig University; Egypt
Alaa
Omran
Clinical Pathology and pediatrics Medicine Departments, Faculty of Medicine, Zagazig University; Egypt
Doaa
AbdElmonem.
10.21608/zumj.2017.4680
Background:-Osteoporosis is an important cause of morbidity in patients with β-thalassemia. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetics factors have been implicated in patients with osteoporosis. Polymorphism at the Sp1 binding site of the collagen type I A 1(COLIA1) gene is thought to be an important factor in development of osteoporosis. Objective:-is to study the relationship between SP1 polymorphism in the collagen type 1 alpha 1 gene and the development of osteoporosis in patients with Beta thalassemia. Methods:-A total of 40 patients with β-thalassemia(21 females &19 males)aged 6-18 yearsand 40 healthy subjects cross matched with age and sex. Serum osteocalcin, serum alkaline phosphatase, calcium and DEXA were examined in all patients. The COLIA1 Sp1genotypes (SS, Ss, ss) were measured by digestion using restriction enzyme (Bal1) of DNA amplified by the polymerase chain reaction (PCR). Results:-SS (G/G) genotype in β-thalassemia major was30.7% and in β-thalassemia intermedia was 49.4% and the Ss (G/T) genotype in βT Major was 55.63% and in βT intermedia was 50.6%, the ss genotype (T/T) type in βTM was 13.67% only. The difference was statistically significant (p= 0.040). There was highly significant difference between thalassemia major and thalassemia intermedia compared to control group as regard Ca, OC, ALP and DEXA (P= 0.000). Conclusions:-Detection base substitutions at the Sp1 binding site on the COLIA1 gene in early years considering an important role in preventing osteoporosis in children with beta -thalassemia.and early mangment of these patients.
Beta-Thalassemia,COLIA1,Osteoprosis
https://zumj.journals.ekb.eg/article_4680.html
https://zumj.journals.ekb.eg/article_4680_87e95a12c0e6a4d907c3f36203eaffc9.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
23
1
2017
01
01
SEPTOPLASTY WITH OR WITHOUT POSTOPERATIVE NASAL PACKING: COMPARATIVE STUDY
1
6
EN
Mohamed
Alshawadfy
Otorhinolaryngology-head and neck surgery department, faculty of medicine, Zagazig University.
Yasser
Fouad
Otorhinolaryngology-head and neck surgery department, faculty of medicine, Zagazig University.
10.21608/zumj.2017.4681
Background Anterior nasal packing after septoplasty, when performed, it aims at reducing the risks of postoperative bleeding and hematomas formation; however, the demerits of anterior nasal packing motivate the idea of septoplasty without nasal packing. Objective: To assess the value of anterior nasal packing after septoplasty. Type of Study: Randomized clinical trial. Patient and Methods: This study was conducted on 50 patients who underwent septoplasty in one institute by the same surgeon (the senior author). They were randomly divided into two groups, in the first group postoperative anterior nasal pack was performed, in the second group there was no packing. Evaluation of subjective symptoms and physical finding was performed at three stages, early postoperative stage (at first and third day), 7 days, 2 weeks, and 2 months after surgery. Results: In the early postoperative stage, the first group experienced less feeling of pain, 2 cases in the second group experienced severe nasal bleeding that requires overnight admission and the bleeding was controlled without packing; also, sensation of pain, lacrimation, swallowing difficulties, and sleep disturbance were significantly higher in the first group in this stage.<br />At the 7th day, the 2nd week, and the 2nd month after surgery, the prevalence of granulations, infection, and crust formations, respectively, were significantly higher in the packing group.<br />Conclusion: Septoplasty without postoperative anterior nasal pack is more compliant with less postoperative morbidities. Packing should be preserved for patients with excessive bleeding during the primary surgery.
internal nasal packing,Nasal Septum,quality of life
https://zumj.journals.ekb.eg/article_4681.html
https://zumj.journals.ekb.eg/article_4681_4ac6e42568327d08c90af3cb201e8c18.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
23
1
2017
01
01
IRON DEFICIENCY ANEMIA , SERUM IRON IN CHILDREN WITH BRONCHIAL ASTHMA
1
11
EN
Wagdy
Elsayed
Department of Pediatric and Clinical Pathology, Banha teaching hospital
Eman
Essa
Department of Pediatric and Clinical Pathology, Banha teaching hospital
10.21608/zumj.2017.4682
Background: Asthma is a chronic inflammatory condition of the lung airways resulting in episodic airflow obstruction. iron deficiency anemia is very common public health problem in developing countries with incidence ranges from 35-90 % in developing countries and may be a risk factor for asthma in children.<br />Objective: We investigated iron deficiency anemia, serum iron, total iron binding capacity, serum ferritin in children with bronchial asthma to study possible association of both conditions and possible role of iron deficiency anemia and iron deficiency in development of bronchial asthma and its exacerbation.<br />Design: Case-control study.<br />Methods: complete blood count with peripheral smear was done; C-reactive protein was determined by enzyme-linked immune-sorbent assay "high sensitive C-reactive protein”. erythrocyte sedimentation rate done by Win Trobe method. Serum iron, total iron binding capacity was measured by spectrophotometer. Serum ferritin was measured by enzyme linked immune assay.<br />Statistical analysis: Results of 40 asthmatic cases were analyzed and compared with 16 healthy controls using SPSS 20.<br />Results: iron deficiency anemia was significantly more frequent in asthma cases compared to healthy controls. Serum iron and serum ferritin were significantly lower in asthmatic cases compared to controls .Non anemic asthmatics showed significant lower hemoglobin , serum ferritin compared with non-anemic healthy controls . Moderate cases of asthma showed significant lower hemoglobin , red cell counts , serum ferritin compared with mild cases , They did not show significant difference with severe cases in these parameters .All three groups" mild , moderate and severe" showed significant differences in these parameters.<br />Conclusion: We conclude that iron deficiency anemia is more prevalent in asthmatic children compared to healthy controls. Asthmatic children have risk of iron deficiency even when they are not anemic. red cell counts and iron deficiency increases with severity of asthmatic attacks.
Childhood asthma,iron deficiency anemia,serum iron,serum ferritin Abbreviations CBC:complete blood count,CRP : C-reactive protein,ELIZA : enzyme-linked immune-sorbent assay,ESR: erythrocyte sedimentation rate Fe :ferrous,FEV::forced expiratory volume G6PD:glucose-6-phosphate dehydrogenase Hct: hematocrit value Hb : hemoglobin,Htc: hematocrit value,IDA : iron deficiency anemia,IgE : immunoglobulin E,LRTI :lower respiratory tract infection,MCH: mean corpuscular hemoglobin MCHC: mean corpuscular hemoglobin concentration,MCV::mean corpuscular volume RDW: red cell distribution wide,RBCs :red cell counts,WBCs : white blood cell counts TIBC :total iron binding capacity
https://zumj.journals.ekb.eg/article_4682.html
https://zumj.journals.ekb.eg/article_4682_1dc8422a24f20f5110f913e597c2a666.pdf