Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study

Ghareeb, Rana Ahmed; Assaf, Magda Ibrahim; Ramadan, Naglaa Ali; Harb, Ola A.

doi:10.21608/zumj.2021.45870.1967

Expression of Discoidin Domain Receptor 2 in Colorectal Carcinoma: An Immunohistochemical Study

Document Type : Original Article

Authors

¹ pathology department, faculty of medicine, zagazig university, Egypt

² Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

³ Pathology department, Faculty of medicine, Zagazig university, Egypt.

⁴ zagazig university Egypt

10.21608/zumj.2021.45870.1967

Abstract

Background: Colorectal cancer (CRC) is considered a highly fatal disease. There is a strong need for novel markers to reach a proper outcome. Discoidin domain receptor 2 (DDR2) belongs to the family receptors tyrosine kinases with a possible relation towards CRC,as DDR2 has a proved role in development of other cancers by enhancing proliferation and metastasis.
Aim of the study: To evaluateDDR2 protein expression and its possible role in CRC for improved patient outcome and decreased morbidity and mortality.
Material and methods: Forty-eight patients diagnosed as colorectal carcinoma were encountered in this study.We analyzed the immunohistochemical expression of discoidin domain receptor 2 and then assessed the correlation of its expression with clinicopathological data.
Results: Discoidin domain receptor 2 expression is significantly associated with tumor size, infiltrating tumor border, presence of necrosis, tumor grade, tumor stage, lymphocytic infiltration and peritoneal spread (P=0.002, P=0.001, P=0.001, P=0.01, P=0.005, P=0.001, P=0.001, respectively), which all are associated with well-known indicators of poor prognosis.
Conclusion: Discoidin domain receptor 2 overexpression, being correlated with poor prognostic factors in colorectal carcinoma, confirm the role of DDR2 in poor outcome.

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