The sensitivity of adult male albino rat prostate to low-dose bisphenol A: a histological and immunohistochemical study

Document Type : Original Article

Authors

1 Histology department, faculty of medicine,Zagazig university

2 Histology faculty of medicine,zagazig university.

3 histology,faculty of medicine zagazig university.

4 Histology,faculty of medicine, zagazig university

Abstract

Context: While, the prostate is sensitive to endocrine hormone levels; both estrogen and androgen are critical in its growth. As a well-known endocrine disruptor compounds (EDCs), bisphenol A can disturb the normal function of these hormones and affects the prostate.
Aim of this study: Hence, this study explored the effect of the exposure to low dose bisphenol A on the histology of dorsolateral prostatic lobes in adult albino rats. Also, this work aimed to highlight the roles of estrogen and androgen.
Materials and methods: Adult (12-14 weeks, 180-200 grams) male albino rats (n = 28) obtained from the breeding animal house, Faculty of Medicine, Zagazig University. These rats were randomly equally divided into two main groups: control group I and bisphenol A treated group II. The rats in group II received 50 mg/kg BPA dissolved in 0.5ml corn oil by oral gavage once daily for 4 weeks. At the time of sacrifice, all rats were anesthetized with ether and blood samples were collected for various biochemical parameters. The prostate glands were dissected out and processed for different histological analysis. Results: These results showed that BPA at low dose may have deleterious alterations on the prostate and disturbed reproductive hormones. Conclusion: It would be imperative to phase out BPA from its uses and healthcare goods in favour of safer alternatives. Also, we recommended further studies to analyze the molecular basis of these alterations.

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Zagazig University Medical Journal
Volume 30, Issue 1.1
January and February 2024
Pages 250-258

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