Assessment risk factors and different lines of treatment of anemia in kidney transplant recipients

Elsaftawy, Mohamed Mohamed; Mahmoud, Medhat Ibrahim; Elhendy, Yaser Abdelmoniem; Akl, Ahmed Ibrahim

doi:10.21608/zumj.2021.102480.2393

Assessment risk factors and different lines of treatment of anemia in kidney transplant recipients

Document Type : Original Article

Authors

¹ urology&amp; Neperology center Mansoura University

² Internal Medicine, Faculty of medicine, zagazig University

³ Internal medicine, faculty of medicine zagazig University zagazig Egypt

⁴ Consultant Of Nephrology, Urology And Nephrology Center; Mansoura University

10.21608/zumj.2021.102480.2393

Abstract

Aim
Screening of the prevalence, etiologies of post transplantation anemia PTA, its implication on graft function and efficacy of different approaches in the management of anemia in a cohort of kidney transplant recipients .

Patient and methods:
We studied 320 kidney transplant recipients; 160 cases (anemic patients ) and 160 control (normal Hb group < br>Univariate and multivariate analysis were done to evaluate the risk of anemia .A prospective investigation of various etiologies of anemia post renal transplantation were done. complete blood picture, Iron indices ,kidney function.
management of anemia according to condition was administered either by Iron therapy or erythropoietin stimulating agents (ESA) therapy Re-evaluation was done after 3 months of. Resistant cases managed by bone marrow biopsy or modify immunosuppression.

Results:
Our cohort included 320 patients with multiple risk factors that showed statistical significance by Univariate analysis.
Incidence of anemia in our group was 25 % per year and prevalence was 20 %.
The risk factors of PTA in our study were female gender, old donors (, low pre transplant Hemoglobin , of acute rejection, chronic rejection , , Bacterial infections.
Low iron indices were also risk factors; and associated with Low eGFR in anemic patients .
Conclusion:
The risk factors of PTA in our study were female gender , old donors, low pre transplant Hemoglobin, acute and chronic rejection , number of acute rejections, bacterial infections and low iron indices associated with progressive decline eGFR.

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