Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma

Hafez, Abeer M; Abdelbary, Abeer M; Elsebai, Eman Ali; Abdelhai, Shaimaa Farouk; Ibrahim, Hanaa M.

doi:10.21608/zumj.2021.97598.2357

Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma

Document Type : Original Article

Authors

¹ pathology department, faculty of medicine ,zagazig university, Egypt

² assistant professor of pathology

³ Clinical oncology department

⁴ Lecturer of Nuclear Medicine, faculty of medicine ,zagazig university, zagazig, Egypt

⁵ pathology department

10.21608/zumj.2021.97598.2357

Abstract

Background: Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid cancer. Fortunately, most PTC patients have favorable outcomes, but about 20% of patients,however, have distant metastases. Therefore, the exploration of new biomarkers to know new characteristics of PTC should be updated.
The aim of our study is to evaluate the possible role of Dynamin-2 and Angiopoietin-like protein 2 (Anglp2) as novel prognostic markers for papillary thyroid carcinoma.
Material and Methods: In our study, we investigated the expression of DNM2 and Anglp2 in 60 cases of PTC . The clinical significance of the markers was evaluated by assessing correlation with the clinicopathological parameters.
Results: High expression levels of both DNM2 and Anglp2 in PTC were significantly associated with advanced tumor stage, lymph node metastasis, bilaterality, multifocal lesion, extrathyroid involvements , recurrence and death.
Conclusions: DNM2 and Anglp2 were independent PTC markers indicating more likely recurrence and poor prognosis. Expression may help to select the high-risk patients for adjuvant targeted therapy.

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