CLINICOPATHOLOGICAL SIGNIFICANCE OF PROGRAMED DEATH -LIGAND -1(PD-L1) AND PROLIFERATION CELL NUCLEAR ANTIGE(PCNA)EXPRESSION IN PROSTATIC CARCINOMA; AN IMMUNOHISTOCHEMICAL STUDY"

Document Type : Original Article

Authors

1 pathology department, zagazig university, zagazig. egypt

2 pathology department, faculty of medicine, zagazig university, zagazig, egypt

3 Clinical oncology department, zagazig university, zagazig, egypt

Abstract

Background: Carcinoma of the prostate is the most diagnosed tumors and the second top reason of cancer-related deaths in American men.
The PD-1/PD-L1 pathway was a T-cell checkpoint pathway that sent repressing signals to T cells that can constrain immunity, PD-L1expression and relation to both pathological, clinical parameters and prognosis were studied in many cancers. (PCNA)is proliferating cellular nuclear antigen, PCNA is an acidic nuclear protein, expressed mainly in phase S of the cellular cycle.
.
Objective: we intended in this work to explore the
immunohistochemical expression of PDL1 & PCNA in prostate cancer
and correlate their expression with other clinicopathologic parameters
Material and methods: 46 cases of prostatic adenocarcinoma were collected from Pathology Department. Faculty of Medicine. Zagazig University between June 2018 to June 2020, using anti PDL1 & PCNA antibodies.
Results: For PDL1 expression;19 cases were positive (41.3%), showing membranous and cytoplasmic expression in tumor cells. Statistically significant relation was found between PDL1 expression and Age, grade, and stage, those who received chemotherapy. For PCNA expression, 33 cases were positive (71.7%) showing nuclear expression. Statistically significant relation was found between PCNA expression and grade, stage and those who received chemotherapy. There is non-significant positive correlation between PDL-1 and PCNA
Conclusion: PDL1 may be a likely new marker or therapeutic
goal for prostatic carcinoma cases, PCNA commonly used as a prognostic marker as an indicator of malignant cellular proliferation.

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Zagazig University Medical Journal
Volume 29, Issue 1
January 2023
Pages 229-237

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