Study of Serum Transforming Growth Factor-β1 and Bone Morphogenetic Protein-7 in Preterm with Respiratory Distress Syndrome

Document Type : Original Article

Author

masaken taawenea 6 bin khaldoon st Tkseem Almoalemeen 7 ahmed saber st

Abstract

Background:
Neonatal RDS is important cause of mortality and morbidity in preterm newborn and occurs exclusively in preterm and its incidence is inversely related to gestational age. TGF β1and BMP 7 are cytokines released In preterm with RDS on mechanical ventilator.
Aim of study:
To study role of both TGF β1and BMP 7 in preterm with RDS managed with mechanical ventilation either receiving or not receiving surfactant thereby.
Subject and Methods:
The study was conducted on 47 preterm with RDS receiving mechanical ventilation. 22 received surfactant and 25 did not received. Antenatal. natal history was taken ,complete clinical examination ,ABGAR score was done . CBC, blood gas analysis, CRP, blood culture, chest x ray was done... TGF β1and BMP 7 was estimated at 2nd and 7th day by ELIZA kits.
Results:
Both TGF β1 and BMP 7 did not show any significant difference between PS and NPS cases at 2nd day of RDS while showed significant higher value at 7th day in NPS cases compared to PS cases. At 7th day Both cytokines decreased significantly in PS group , In NPS group TGF β1 raised significantly while BMP 7 did not changed significantly compared to 2nd day . No significant relation between both cytokines at 2nd day while showed positive correlation at 7th day in RDS cases (PS+NPS ) with no relation in NPS cases at 7th day. .
Conclusion:
Both TGF β1and BMP 7 significantly rises in RDS cases and decrease with surfactant therapy. Both cytokine

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Zagazig University Medical Journal
Volume 28, Issue 5
September 2022
Pages 1135-1140

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