Neuropathological changes and neurological manifestations in COVID-19 cases: A narrative review

Document Type : Review Articles

Authors

1 Undergraduate medical student, faculty of medicine, Zagazig University, Zagazig, Egypt

2 Medical microbiology and immunology, faculty of medicine, Zagazig University, Zagazig, Egypt

Abstract

Background: Corona virus disease 2019 (COVID-19) has a lot of effects on the different tissues of human body particularly the respiratory system. Recently, there have been a lot of evidences that severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has some effects on the nervous system especially brain tissues. In the early months of COVID-19 pandemic, the physicians focused on treating and dealing with lung damage and circulatory system support, but later the effects of neurological deterioration started to appear. In this review article we will discuss the different routes of administration of the virus into the central nervous system, neuropathological changes in the brain tissue, clinical neurological manifestations of the patients with COVID-19 and the histopathological changes in COVID-19 cases with neurological findings.
Conclusions: the brain tissue is affected by SARS-CoV-2 infection which causes a lot of neuropathological changes and manifests by different neurological signs and symptoms which are to be discussed.

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Zagazig University Medical Journal
Volume 28, Issue 5
September 2022
Pages 912-917

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