Pleurodesis Using Bleomycin Ampoules, Doxycycline Capsules and Povidone Iodine Solution in Patients with Malignant Pleural Effusion in Zagazig University Hospitals

Document Type : Original Article

Authors

1 Department of Medical Oncology, Faculty of Medicine Zagazig University, Egypt

2 Department of Cardiothoracic Surgery, Faculty of Medicine Zagazig University, Egypt

Abstract

Abstract
Background: Malignant pleural effusions (MPEs) can occur due to practically any type of cancer. MPEs frequently impairs quality of life. There are numerous techniques for managing MPEs; each drains the pleural space and relieves respiratory symptoms. Pleurodesis is described as the formation of a symphysis between two layers of pleura in order to avoid the recurrence of effusions. Numerous chemical compounds are being investigated for use in pleurodesis. Aim of work: The purpose of this research was to examine the medical pleurodesis results performed with three different chemical agents in order to determine the most effective one with the fewest side effects. Patients and Methods: This study enrolled 60 patients from Medical Oncology department at Zagazig university Hospitals, Egypt between January 2021 and January 2022. All patients were with MPEs. We enlisted 60 patients, separated them into three groups of 20 each, and had them undergo medical pleurodesis with three different chemical agents in comparison: povidone-iodine, doxycycline, and bleomycin. Sex, age, side of the effusion, treatment outcome (success and failure), and adverse effects were analyzed. Results: After pleurodesis, the findings were evaluated, and final success rates were 80% for povidone-iodine, 75% for bleomycin, and 65% for doxycycline. Conclusions: When utilized appropriately, povidone-iodine, doxycycline, and bleomycin are practically similarly efficient and safe sclerosing agents. While the povidone-iodine and doxycycline are similarly efficient and secure as bleomycin as chemical agents for pleurodesis in cases of MPEs, they are less costly and more commonly available.
Keywords: pleurodesis, malignant, effusion, doxycycline, bleomycin, povidone-iodine.

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Zagazig University Medical Journal
Volume 28, Issue 5
September 2022
Pages 1022-1028

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