soliman, A., El Ebeary, M., Gouda, T., Ebied, A. (2019). SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY. Zagazig University Medical Journal, 25(1), 155-163. doi: 10.21608/zumj.2019.24912
Ali Mohamed soliman; Mahmoud El Sayed El Ebeary; Tarek Abdel Rahman Gouda; Ahmed Ahmed Ebied. "SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY". Zagazig University Medical Journal, 25, 1, 2019, 155-163. doi: 10.21608/zumj.2019.24912
soliman, A., El Ebeary, M., Gouda, T., Ebied, A. (2019). 'SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY', Zagazig University Medical Journal, 25(1), pp. 155-163. doi: 10.21608/zumj.2019.24912
soliman, A., El Ebeary, M., Gouda, T., Ebied, A. SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY. Zagazig University Medical Journal, 2019; 25(1): 155-163. doi: 10.21608/zumj.2019.24912
SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY
Background: Epilepsy is a common serious neurological disorder. Medical histories and electroencephalogram (EEG) are not always sufficient for epilepsy diagnosis; therefore, exploring novel methods for the accurate diagnosis of epilepsy is of great importance. Recent studies indicate that Matrix metalloproteinases (MMPs) especially MMP-2 is sensitive to seizures thus; MMP-2 may be a potential biomarker for epilepsy diagnosis. Subject and method: Thirty four epileptic patients older than 2 years subjected to: Detailed medical history, general and neurological examination, routine laboratory studies, EEG , Brain magnetic resonance imaging (MRI), and serum MMP-2 level measurement . Thirty four age and sex matched healthy controls were selected and their serum MMP-2 were obtained. Results: serum MMP-2 levels were statistically significantly low in patient with idiopathic epilepsy compared to control group .Levels were less in patient with focal epilepsy than those with generalized epilepsy.Serum MMP-2 was lower in drug resistant epileptic patients and highest in newly diagnosed patients with negative correlation observed between duration of epilepsy and MMP-2 levels. Sensitivity of MMP-2 as biomarker was 85.29% with 97.06 % specificity. Conclusion: MMP-2 levels decreased in patients with epilepsy especially those with focal seizures. This tool may be a helpful diagnostic biomarker for epilepsy with a good sensitivity and specificity.
Top