Evaluation of Cyclin-Dependent Kinase Inhibitor 2A and Hepatocyte Nuclear Factor-1A Gene Polymorphisms in Coronary Artery Diseases

Document Type : Original Article

Authors

1 medical biochemistry, faculty of medicine, Zagazig university, Egypt

2 cardiology department, faculty of medicine, Zagazig university, Egypt

3 medical biochemistry, faculty of medicine,zagazig university, Egypt

Abstract

Background: Blood lipid-regulating and cell proliferation-regulating genes have both been connected to the development of coronary artery disease (CAD).
Objective: to find the correlation between CDKN2A rs3088440, HNF1A rs55783344CT gene polymorphisms and CAD.
Subjects and methods: One hundred and six participants were subjected to this case-control study; case group I: patients with CHD and control group II: Normal healthy people. Subjects underwent a comprehensive history and physical examination, standard laboratory tests, and coronary angiograms. CDKN2A rs3088440 and HNF1A rs55783344CT gene polymorphisms was done by (PCR-RFLP).
Results: CT genotype and CT+TT of HNF1AC were statistically Signiant higher in CAD cases than controls. T allele of HNF1AC was much higher in CAD cases than controls, with a significant difference between 2 groups. Proportion of those with the CDKN2A GA+AA genotype in the CAD patients was significantly higher than in the control group. Also, the frequency of the CDKN2A A allele was significantly different between CAD cases and controls.
Conclusion: Coronary heart disease (CHD) has a complex etiopathogenesis and a multifactorial origin. SNPs are potential risk factors of CHD. CDKN2A rs3088440 (G>A) and HNF1A rs55783344CT gene polymorphisms be a factor in pathogenesis of CHD

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Zagazig University Medical Journal
Volume 30, Issue 3
May and June 2024
Pages 859-868

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