Detection of subclinical cardiac dysfunction in healthy medical workers with vitamin D deficiency

Seaoud, Elshaimaa Ali M.Elsadek; Elkot, Moataz A.; Eldeeb, Seham Mahmoud; Wageeh, Shaimaa

doi:10.21608/zumj.2023.199367.2768

Detection of subclinical cardiac dysfunction in healthy medical workers with vitamin D deficiency

Document Type : Original Article

Authors

¹ Department of Cardiology ,Faculty of Medicine,Zagazig University,Zagazig,44159,Egypt

² . Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.

³ public health and community medicine department, faculty of medicine, zagazig university mitghamr, dakahlia, egypt

⁴ Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.

10.21608/zumj.2023.199367.2768

Abstract

Background

Vitamin D is a necessary hormone in many tissues including cardiac myocytes. The autocrine and paracrine regulation of cellular growth differentiation and function in several organs depends on it through preventing the activation of the heart’s renin-angiotensin system and natriuretic peptides vitamin d regulates calcium flux extracellular matrix turnover and myocardial contractility.

Our study aimed to identify the relationship between vitamin D deficiency and myocardial function in medical staff with nohistory of cardiac disease and normal transthoracic echo-Doppler parameters.

Methods

A comparative cross-sectional study involved 80 doctors, nurses, and technicians working at Zagazig University Hospitals; they were divided into two groups based on 25(OH) D levels: Group A (n=40) had a low vitamin D level of <20 ng/mL & Group B (n=40) had an average vitamin D level (>20 ng/ml). Both groups were subjected to conventional echocardiography and tissue Doppler imaging.

Results

The study found significantly higher Left ventricular and right ventricular Tei index in group A compared to group B (P value =0.01 and ˂0.001), respectively We also found a significantly higher tricuspid deceleration time (DT (t)), tricuspid lateral A' and significantly longer tricuspid interventricular isovolumetric relaxation time (IVRT(T) in group A compared to group B. Finally, a receiver operating characteristic (ROC) curve was performed which showed that 25(OH) D less than 19.5 was found to have 83% sensitivity and 65% specificity in determining a high RV tei index (>0.55).

Conclusions

Our study showed that Vitamin D deficiency affects both the systolic and diastolic function of the heart.

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