Prognostic Significance of 13q14 Deletion in Egyptian Chronic Lymphocytic Leukemia Patients

Mohamed Easa, Manal; M.AbdElmonem, Doaa; Embaby, Ahmed; Ibrahim Ismail, Weaam

doi:10.21608/zumj.2023.223452.2827

Prognostic Significance of 13q14 Deletion in Egyptian Chronic Lymphocytic Leukemia Patients

Document Type : Original Article

Authors

¹ lecturer of clinical pathology- faculty of medicine- zagazig university- zagazig- Egypt

² assistant professor of Clinical Pathology, faculty of medicine - Zagazig university, Egypt

³ Lecturer of Internal Medicine,Clinical Hematology Unit Faculty of Medicine, Zagazig University, Zagazig Egypt

⁴ lecturer of Clinical pathology department, Zagazig faculty of medicine ,Zagazig university

10.21608/zumj.2023.223452.2827

Abstract

Background: chronic lymphocytic leukemia (CLL) is B lymphocyte malignancy affect mainly adult, its clinical course is variable. 13q deletion is common cytogenetic abnormality found in CLL patients and in general it is associated with a good prognosis. However, it was noticed that there are clinical heterogeneity among CLL patients harboring 13q deletion which may be attributed to type, size, or rate of 13q deletion so, it was important to clarify the source of this heterogeneity.

Patients and methods: seventy one CLL patients were examined by conventional cytogenetic and fluorescent in situ hybridization (FISH) for 13q14 deletion.

Results: deletion of 13q14 was detected in 45/71 CLL patients (63.4%) and those had significantly lower absolute lymphocytic count (ALC) and hemoglobin concentration, 53.3% of positive patients were in Binet stage A, and 31.1% of them required chemotherapy. In 38 patients 13q14 deletion was found as an isolated abnormality and those had significantly lower WBCs count, ALC and LDH than those with accompanied cytogentic abnormalities (non-isolated). The deletion was found at a rate (≥80%) in (8/ 38) patients with isolated deletion type and those had a significantly shorter time to treatment. The 13q14 deletion was biallelic in only 3/38 of patients with isolated type and all of them had a diffuse bone marrow infiltration pattern.

Conclusion: 13q14 deletion is common cytogenetic abnormality in CLL patients and has variable impact on the disease condition according to specific features of deletion such as isolated or non- isolated, deletion rate, and deletion type being monoallelic or biallelic.

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