Correlation between Uric Acid, Albuminuria and Cardiovascular Outcome In Patients With Diabetes Mellitus

Document Type : Original Article

Authors

1 Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2 Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagagzig, Egypt

Abstract

Background: Many studies have shown an association between uric acid (UA) and cardiovascular (CV) outcome in general population and diabetes, also the association between albuminuria and cardiovascular outcome is well established. The link between serum UA levels and albuminuria with subsequent CV affection is not yet clear. For this reason, we aimed to study such association. Method: One hundred and eight individuals with type 2 diabetes which were divided into two groups each constitute of 54 individuals according to presence or absence of CV disease. Routine laboratory investigations together with serum UA and urinary albumin to creatinine ratio (uACR) was analyzed in the two groups they were then correlated to each other and to different study parameters and future CV event using Framingham risk score (FRS). Results: The present study proved that there is statistical significant difference as regard risk of CVD as calculated by FRS being higher in diabetic patients with high serum UA (SUA) levels compared to those with low uric acid levels; the same apply for those with high urinary ACR. Serum UA was found to be correlated with urinary albumin execretion in patients with diabetes with and without CVD (n=108, r=0.450, p

Keywords

Zagazig University Medical Journal
Volume 26, Issue 1 - Serial Number 1
Medicine - Pediatrics - Laboratory Medicine
January and February 2020
Pages 7-16

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