Diagnostic and Prognostic Utility of FFAR2 Gene Expression in Peripheral Blood as a Potential Biomarker for Acute Coronary Syndrome

Fawzy, Heba; Ghareeb, Mohammed S.; Mosaad, Hala

doi:10.21608/zumj.2023.239890.2926

Diagnostic and Prognostic Utility of FFAR2 Gene Expression in Peripheral Blood as a Potential Biomarker for Acute Coronary Syndrome

Document Type : Review Articles

Authors

¹ Lecturer at Medical Biochemistry Department, Faculty of Medicine, Zagazig University

² Assistant Professor at Cardiology Department, Faculty of Medicine, Zagazig University

³ Assistant Professor at Medical Biochemistry Departement , Facultay of Medicine , Zagazig University

10.21608/zumj.2023.239890.2926

Abstract

Abstract

Background: Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality. Presently, there is no convenient marker that can precisely expect the onset of ACS besides its prognosis. Free fatty acid receptor 2 (FFAR2) has lately been proposed to protect from heart diseases.

The aim of the study was: to assess whether the expression of FFAR2 in peripheral blood is a valuable biomarker for diagnosis of ACS and prediction of adverse cardiac events (ACEs) among ACS patients with controlled and uncontrolled DM.

Methods: Peripheral venous leukocytes were collected from 281 patients, 133 as control group (Group I) and 148 diabetic patients admitted with ACS (Group II). Group II was subdivided into Group IIa, 67 ACS patients with controlled blood glucose and Group IIb, 61 ACS patients with uncontrolled blood glucose. The expression level of FFAR2 was estimated by real time PCR.

Results: FFAR2 expression in ACS patients was significantly lower than that in the control group. Moreover, the FFAR2 level in ACS with uncontrolled blood glucose was lower than that in ACS patients with controlled blood glucose level. The ROC curve analysis showed that FFAR2 level had excellent sensitivity and moderate specificity to identify patients at risk of having ACE .

Conclusion: FFAR2 could act as a potential biomarker in diagnosis of ACS and predicting its complications.

Keywords: ACS, FFAR , ACE , Real time -PCR.

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