Plasma MicroRNA-133a as a Potential Predictor for Coronary Artery Stenosis Severity

Document Type : Original Article

Authors

1 Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Zagazig University

2 Medical Biochemistry Department-Faculty of Medicine- Zagazig University-Egypt

3 Cadiology Department , Faculty of Medicine , Zagazig University

Abstract

Background: Several scoring systems tried to determine coronary artery stenosis severity to investigate its correlation with laboratory parameters.
Aim of the study: To investigate the correlation between the expression levels of circulating miRNA-133a & coronary artery stenosis severity .
Patients and Methods: The study was conducted in Medical Biochemistry Department and Cardiology Department - Faculty of Medicine, Zagazig University& Medical Scientific Research Center. It included 72 subjects classified into 2 groups; Group (1): included 18 healthy subjects served as a control. Group (2 included 54 acute coronary syndrome patients. It was subdivided into 3 subgroups each 18 patient: unstable angina , non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction . Plasma miRNA-133a expression level was analyzed by real time PCR. Cardiac Cathetrization was done for showing the severity of stenosis.
Results: The present study showed high significant positive correlation between miRNA-133a level and coronary stenosis percentage in unstable angina group (p

Keywords

Zagazig University Medical Journal
Volume 26, Issue 1 - Serial Number 1
Medicine - Pediatrics - Laboratory Medicine
January and February 2020
Pages 64-74

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