Correlation between Insulin Resistance with severity of Vasomotor symptoms in Postmenopausal Women

ELnaptiti, Ibrahim Adel; Saad, Mohamed S S; Abdelghany, Amany Mohamed Ahmed; Abdelfattah, Azza Hassan

doi:10.21608/zumj.2024.280875.3306

Correlation between Insulin Resistance with severity of Vasomotor symptoms in Postmenopausal Women

Document Type : Original Article

Authors

¹ Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

² internal medicine department,faculty of medicine ,zagazig university ,sharkia,egypt.

³ Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Egypt

⁴ Lecturer of Internal Medicine, Faculty of Medicine, Zagazig University

10.21608/zumj.2024.280875.3306

Abstract

Background: Hormonal fluctuations could affect vasomotor symptoms (VMS), particularly the decline in estrogen levels that accompany menopause. This research aimed to assess the correlation between insulin resistance and the severity of VMS in postmenopausal women.

Methods: Seventy-four postmenopausal women (at least 12 consecutive months of amenorrhea) aged 40 years or more in this comparative cross-sectional study were classified regarding VMS into two groups (37 in each group): Group I: Postmenopausal women without VMS, Group II: Postmenopausal women with VMS. A menopausal Vasomotor Symptoms (MVS) survey was administered to all study participants. Laboratory investigations included Hemoglobin A1c, fasting blood glucose, and Insulin resistance index (HOMA-IR).

Results: There were statistically significant positive correlations between HOMA-IR score and body mass index, Fasting Insulin, HBA1C, FBS, PBS, HDL, TGs, cholesterol, and estimated glomerular filtration rate to VMS (P<0.001) with a significant negative correlation between VMS and age. (P<0.05). HOMA-IR at cutoff value = 1.67 was a good predictor test for the severity of VMS among postmenopausal women. HOMA-IR, Age, BMI, and HbAlc were independent predictors for the severity of VMS among postmenopausal women (P<0.05) with Confidence interval (CI): (1.401 – 2.009, 0.564 – 0.917, 0.771 – 2.016, 0.564 – 0.917 respectively) and odd Ratios (OR) of (3.678, 1.719, 9.247, and 7.719 respectively).

Conclusion: In postmenopausal women, there was a correlation between IR and VMS providing a strong basis for clinical diagnosis and treatment to improve quality of life of postmenopausal Female patient.

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