CORRELATION BETWEEN VITAMIN D3 AND FASTING PLASMA GLUCOSE, A1C AND SERUM LIPIDS IN NON-DIABETIC SUBJECTS

Objective: To study the correlation between vitamin D3 and fasting plasma glucose, haemoglobin A1c, and lipids in non diabetic persons . Patients and methods: Eighty-eight healthy Saudi females; aged 18 to 50 years were recruited from an endocrine clinic in a tertiary care hospital in southern region of Saudi Arabia. Exclusion Criteria: Diabetes mellitus, malabsorption, significant cardiac, hepatic, oncologic, renal or psychiatric disease. Use of medications known to affect serum vitamin D3, plasma glucose or lipid profile. After an overnight fasting blood samples were collected for laboratory measurement of fasting plasma glucose, lipids, haemoglobin A1c (HbA1c) and vitamin D3 [25(OH)D3].
Results: Fasting plasma glucose inversely correlated to vitamin D3 level (p=0.034). No significant correlation was found between vitamin D3 and HbA1c (p=0.23) or any of the components of lipid profile. Conclusion: It seems that vitamin D3 affects glucose homeostasis. The lower the vitamin D3 level, the higher the blood sugar. Vitamin D3 level is not correlated to HbA1c in our study population of non-diabetic females. This may be attributed to age and ethnicity of the study group. Vitamin D3 level is not correlated to fasting lipid profile.