@article { author = {mohammed ashour, Nashwa and bahgat, shereen and zaiton, moustafa and ragab, hosnia}, title = {THE IMPACT OF MATERNAL OBESITY ON MOTHER AND NEONATAL HEALTH: AC0HORT STUDY IN ZAGAZIG UNIVERSITY HOSPITALS}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {832-839}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.11615.1198}, abstract = {Background: Obesity would increase the possibility of unfavorable effects on maternal and fetal outcomes. So, it is important to investigate the relationship between maternal obesity and its possible effects and determinants. Subject & Methods: A cohort study was conducted on 104 pregnant women at the 3rd trimester attending antenatal clinic of zagazig university hospital for routine antenatal care. Data was collected by semi-structured interview, follow up sheet in the 3rd trimester, as well as labor, and delivery sheets and neonatal assessment sheet. Results: Findings of the study revealed that, women aged ≥ 30 years old tend to be obese (p = 0.005). Multipara has 3 times risk of obesity (Relative risk (RR) = 3.0, 95 % Confidence Interval (CI) = 2.27-15.0) than primipara. Obese women had 2 times risk to have miscarriage than non-obese (RR =2.2, 95 % CI = 1.18-8.21). Obese pregnant women were liable to pregnancy complication such as gestational hypertension, gestational diabetes and preeclampsia (p = 0.03). Also they had 6 times risk to have cesarean delivery (RR =5.5, 95 % CI = 1.17-3.55) than non-obese women. Fetal macrosomia are more common among babies born to obese mothers (p < /p>}, keywords = {Maternal obesity,Pregnancy complications,fetal macrosomia and APGAR scoring}, url = {https://zumj.journals.ekb.eg/article_33117.html}, eprint = {https://zumj.journals.ekb.eg/article_33117_935c3264fe1ebc29cbb3c6983296aea5.pdf} } @article { author = {Mohamed, mona and hammad, marwa and atwa, essam and hussein, atef}, title = {Q192R PARAOXONASE 1 GENE POLYMORPHISM AMONG RHEUMATOID ARTHRITIS PATIENTS IN ZAGAZIG UNIVERSITY HOSPITALS}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {862-868}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.12597.1223}, abstract = {Background: Rheumatoid arthritis patients (RA) have expanded cardiovascular morbidness and death rate. Paraoxonase1 (PON1) polymorphism has been related to expanded cardiovascular hazard. Aim of the work: to assess the relationship between PON1 gene polymorphism and RA. Subjects and methods: A case control study was conducted in Rheumatology and Rehabilitation Department in cooperation with Medical Biochemistry and Biology Department, Zagazig University Hospitals on 106 subjects. They were divided randomly into case and control groups, full history was taken from all patients, also locomotor examination, laboratory and radiological evaluation were done. Genotyping of PON1 gene polymorphism was studied in both groups Results: Regarding PON1 polymorphism genotypes, the difference in PON1 genotypes frequency was not significant among RA patients and controls (P>0.05). Levels of total triglycerides, HDL and LDL were different significantly in both groups. Conclusion: Although RA patients had higher cardiovascular risk, PON1 Q192R polymorphism was not prominent in RA patients contrasted with controls.}, keywords = {Key words: Rheumatoid arthritis,PON1 polymorphism,cardiovascular risk}, url = {https://zumj.journals.ekb.eg/article_36378.html}, eprint = {https://zumj.journals.ekb.eg/article_36378_2f3ed4d391976baf5e81b86ffddfaf96.pdf} } @article { author = {Mohamed Ahmed, Ahmed and mohamed ebrahim, Ghada and Mohamed ghazal, Kamel and El-Menshawy, Mahmoud}, title = {Percutaneous coronary intervention in chronic total coronary occlusions : Parameters of success}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {840-852}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.13606.1255}, abstract = {ABSTRACTBackgroud:chronic total coronary occlusions (CTOs) are the most technically challenging lesion that interventional cardiologists might face, and treatment of these lesions will have great effect on future percutaneous coronary intervention (PCI) success. Despite notable advances in the procedural and medical outcomes of percutaneous revascularization, CTO remains the unresolved problem in interventional cardiology.Objective: To detect the pre-interventional predictors for procedural success of PCI of CTO and assess improvement of Left ventricular ejection fraction after successful PCI of CTO.Methods: 52 Patients with CTO of more than 3 months duration having significant angina (Class III / IV) or recent acceleration of previously chronic stable angina admitted to zagazig university hospital and Kobry El-Kobba Military Hospital during period from januray 2017 till januray 2018 were included in the study. Results: Predictors of technical success in CTO intervention were coronary artery diameter > 3mm , short CTO length less than 20mm , tapered CTO stump, absence of calcificlesion , bending angle less than 45 degree and prescence of microchannels. While small coronary artery diameter >3mm, CTO length more than 20mm , presence of bridging collaterals and high J-CTO score were predictors of technical failure .Conclusion: PCI for coronary CTO should be performed for documented viable myocardium in the territory supplied by the chronicaly occluded artery. Proper evaluation of the clinical and angiographic characteristics of the patient to choose the proper plan for the recanalization. Success of PCI to CTO cause significant increase left ventricular ejection fraction.}, keywords = {percutaneous coronary intervention,coronary total occlusions,Coronary Artery Bypass Graft}, url = {https://zumj.journals.ekb.eg/article_37989.html}, eprint = {https://zumj.journals.ekb.eg/article_37989_efc0d3b371a34f8c5b0de400e967ab43.pdf} } @article { author = {Amer, Ahmed and Abdelhaleim, ayman and Salah, hossam Eldin}, title = {CD34 Expression in Adult Acute Myeloid Leukemia is an Independent Poor Prognostic Factor}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {823-831}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.10047.1146}, abstract = {Background: CD34 is a marker of HSCs and haematopoietic progenitor cells as well as a marker of several other non-haematopoietic cell types. There is much debate on whether expression of CD34 on malignant myelogenous leukaemia blast cells affect the prognosis and response to treatment or not and if it is an independent prognostic factor or affected by other prognostic factors, especially the cytogenetics.Methods: This prospective study had been carried out at Haematology Unit, Zagazig University Hospitals. It included 90 denovo AML patients. CD 34 expression was identified by Flowcytometric studies of bone marrow aspirate. it was considered positive if a cut-off level of 10% expression was exceeded. This was then analysed to detect its impact on outcome and its correlation to other risk factors especially cytogenetics.Results: sixty (66.7%) of the AML patients were CD34 positive and their survival was shorter than patients with negative CD34 expression. CD34 positive AML cases had lower rate of achievement of complete remission. CD34 positivity was significantly linked to less differentiated FAB subtypes (M0, M1, and M2) as well as non-favorable risk cytogenetics. However, multivariate cox regression analysis proved that CD34 positivity confers an independent poor prognostic impact apart from its association with these poor risk factors.Conclusions: CD34 expression is a poor prognostic biomarker of survival in AML patients, independent from other poor prognostic factors. Its role in AML different subgroups layered by different gene mutations and chromosomal aberrations needs further extensive studying.}, keywords = {AML,CD34,prognosis,Cytogenetics}, url = {https://zumj.journals.ekb.eg/article_38329.html}, eprint = {https://zumj.journals.ekb.eg/article_38329_8d6df310d3b87ba7a081760787eb11d3.pdf} } @article { author = {alshlbh, rafiq and Mohamed, Abdelfatah and Alcekelly, Montaser and Ibrahim, Ismail}, title = {Correlation between QRS Dispersion and Severity of Coronary Artery Disease Detected by GENSINI score in Patients with non ST Elevation Myocardial Infraction}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {814-822}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.7093.1015}, abstract = {Objective: The aim of the current study was to study the correlation of QRS dispersion with the severity of coronary artery lesion in patients with NSTEMI detected by GENSINI score (short term outcome). Methods: The whole study group included 96 (63 males and 33 females) patients presented with NSTEMI. Age ranged from 46 and 75 years with a mean of 57.4 ± 6.8. Table (7) summarizes clinical baseline and laboratory data of the studied patients. Results: study was include 96 consecutive patients whom were admitted to Cardiology Care Unit for NSTEMI in the period between Marsh to September 2018. The patients were informed with the necessary information of the study. Study was approved by the research ethical committee of Faculty of Medicine, Zagazig University, and a written informed consent was obtained from all participants (patients included 63 males and 33 females patients with their age ranged from 46 and 75 years with a mean of 57.4 ± 6.8) . Conclusion: In the current study, we found highly significant positive correlation between admission heart rate and maximum high-sensitive troponin T level and Gensini score > 20 in the setting of NSTEMI. A significant positive correlation between age, male gender, QRS measurements, QTc dispersion, LVESD and Grace score and Gensini score > 20 was found in the setting of NSTEMI. There was a negative significant correlation between LVEF and Gensini score > 20.}, keywords = {QRS Dispersion,severity,Coronary Artery Disease,Gensini score,NSTEMI}, url = {https://zumj.journals.ekb.eg/article_41336.html}, eprint = {https://zumj.journals.ekb.eg/article_41336_311db3974537c6bdda2a2da1077d5461.pdf} } @article { author = {Reda Abd Ellatif, Ahmed and El Safy, Eman and El Masry, Nagda and El-Shabrawy, Amany}, title = {Neuological Soft signs in euthymic bipolar I patients: State or trait markers.}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {715-724}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.13938.1271}, abstract = {Background: Neurological soft signs (NSS) are endphenotypic markers widely studied in schizophrenia, but few papers have focused on evaluating them in bipolar disorder (BP) and their first degree relatives.Objectives: the aim of this study was to determine the prevalence and scores of NSS in bipolar I patients in remission state compared to their healthy relatives and controls, in addition to explore correlation with some sociodemographic data and clinical features of these euthymic patients.Methods: The study was conducted on 30 euthymic bipolar 1 patients, 30 their healthy relatives and 30 control subjects. The neurological soft signs were assessed by the Neurological Evaluation scale (NES). Bipolar I. Euthymic patients were also assessed by young Mania rating scale (YMRS) and the Hamilton Depression rating scale (HDRS). All subjects were recruited from Zagazig university Hospital. A simple questionnaire was structured for all participants to collect some sociodemographic data.Results: NSS are prevalent in bipolar 1 euthymic patients and their first degree relatives, though significantly more in affected subjects.Conclusion: This suggests that NSS could be considered as trait marker supporting the theory that bipolar disorder may be a neurodevelopmental disorder.}, keywords = {Neurological soft sign,Bipolar Disorder,euthymic patients}, url = {https://zumj.journals.ekb.eg/article_42939.html}, eprint = {https://zumj.journals.ekb.eg/article_42939_dde3ff6fcc989914e0cb9ede64ed8c35.pdf} } @article { author = {Nafea, Alaa and abdellatif, dalia and Rasheed, Ehab}, title = {Airway pressure release ventilation in pediatric respiratory failure. Does it really work?}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {753-757}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.14885.1345}, abstract = {Background: Airway pressure release ventilation (APRV) is a novel mode of ventilation. It is a form of bi-level assisted ventilation using continuous positive airway pressure (CPAP) with periodic decrease in pressure, either to a lower CPAP pressure or to atmospheric pressure. Aim of the work: to assess the ability of the APRV mode to improve the oxygenation and the mortality in cases with respiratory failure. Subjects and methods: A clinical trial was conducted in Pediatric intensive care unit in Zagazig university children's hospital included 76 patient. They were selected after failure of conventional mechanical ventilation, all patients were subjected to full history taking and full physical examination, routine labs and serial Chest X-rays, serial arterial blood gases and serial follow up of the ventilator parameters were observed. Results: APRV showed significant improvement in PaO2/FiO2 ratio and O2 saturation. Conclusion: APRV showed promising gateway to the cases of respiratory failure who failed their chances on conventional mechanical ventilation. Future studies are needed to compare both modes to assess the superior of one to another.}, keywords = {Airway pressure release ventilation,Respiratory failure,Pediatrics}, url = {https://zumj.journals.ekb.eg/article_43605.html}, eprint = {https://zumj.journals.ekb.eg/article_43605_f4861c85a8546bb180484c07422ea7f5.pdf} } @article { author = {ahmed, asmaa and helmy khater, nahed and karam, nehad}, title = {ASSESSMENT of BLOOD MANGANESE CONCENTRATION IN CHILDREN WITH IRON DEFICIENCY ANEMIA}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {708-714}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.13492.1248}, abstract = {Abstract: Anemia is a global health problem, which affects not only developing countries, but also developed countries as well. Iron deficiency affects about 30% of the world’s population, making it one of the most prevalent nutritional problems worldwide. A nutritional iron deficiency may cause high absorption of Mn. Overexposure to Mn can cause an overwhelming neurologic impairment that is clinically called “manganism”. The aim of this study was to assess blood manganese concentration in children with iron deficiency anemia. Patients and methods: This is a prospective cohort study carried out in department of Pediatrics, faculty of medicine, Zagazig University, in a 6 months duration, on 50 children with iron deficiency anemia. CBC, ferritin and TIBC are used for diagnosis of iron deficiency anemia. Assessment of manganese levels was done with division of patients into normal and high manganese level.Result: most cases of iron deficiency anemia associated with increase blood manganese level.Conclusion: Blood manganese concentration is elevated in children with iron deficiency anemia.}, keywords = {iron deficiency anemia,Manganese,iron,transferrin}, url = {https://zumj.journals.ekb.eg/article_45317.html}, eprint = {https://zumj.journals.ekb.eg/article_45317_2d73014ce6a31413f1ee8174f8b1728b.pdf} } @article { author = {Mansour, Reham and Abu Zeid, Ali and Bahaa El Din, Rasha}, title = {Cross sectional study to assess Malnutrition and associated risk factors among primary school children in Kafr Sakr, Sharqia, Egypt}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {725-734}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.14033.1284}, abstract = {ABSTRACTBackground: Malnutrition is considered a global health burden mainly in the developing countries, because of the high prevalence and it's undesirable consequences on health. Objective: Assessment of the nutritional status of school age children and its associated risk factors. Subject and methods: A cross-sectional study conducted among 341 primary school children aged (6-12) years in Kafr Sakr district, Sharqia governorate, Egypt. The assessment done by filling questionnaire about socio-demographic data, clinical examination, laboratory tests for hemoglobin detection and stool examination for all children. Results: The prevalence of stunting and underweight was 21.4% and 21.9% respectively. Anemia prevalence was 53.1% , parasitosis prevalence was 32.8%, while hair lice prevalence was 10.9%. The results revealed that stunting was significantly associated with underweight, parasitosis and low socioeconomic class. Underweight was significantly associated with anemia, parasitosis and low socioeconomic class. Conclusion and Recommendations: The present study results showed high malnutrition prevalence among primary school children which is significantly associated with anemia and parasitosis. So, we recommend emphasizing the importance of screening program of anemia and parasitosis with focus on school children.}, keywords = {Keywords: Malnutrition,Anemia,parasitosis}, url = {https://zumj.journals.ekb.eg/article_45318.html}, eprint = {https://zumj.journals.ekb.eg/article_45318_a4a5114d59e5974873156a63286f6bfd.pdf} } @article { author = {Awad, Mohamed and Shouman, Waheed and Farouk, Mohamed and Elhawary, Abeer}, title = {Assessment of Weaning Practice In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients at Respiratory Intensive Care Unit of Zagazig University Hospitals}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {883-891}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.15367.1377}, abstract = {Background:Chronic obstructive pulmonary disease is a significant disease which can affect public health and classified as 3rd cause of death ,and described as a preventable and treatable disease associated with air flow limitation which is not completely reversible.40% to 50% of the duration of the mechanical ventilation (MV) support period can be spent in weaning.So the target of this study to evaluate weaning practice in mechanically ventilated patients with COPD disease due to acute exacerbation.Subjects and Methods: 24 COPD patients admitted to the ICU due to hypercapnic respiratory failure and who required invasive positive pressure mechanical ventilatory support were eligible for enrollment. After the acute phase, all eligible patients were subjected to an initial weaning trial.Results: As regard previous history of ventilator support and source of referral there was statistically non significant difference between the patients who failed and succeed weaning. As regard ventilator machine trade name there was statistically non significant difference for weaning success. There was statistically non-significant difference for weaning success regarding diaphragmatic ultrasound parameters (TDI, End inspiratory TDI and end expiratory TDI), but regarding diaphragmatic excursion there was significant difference. As regard Pi max and PaO2/FiO2 there was statistically significant difference for weaning success but regarding rapid shallow breathing index (RSBI) there was statistically non-significant difference. There was statistically non-significant difference for weaning success as regard method of weaning.Conclusion: Weaning success is very high in specialized tertiary ICU; 91.7%. Pimax, PaO2/ FIO2 and diaphragmatic excursion are a good predictor for weaning success.}, keywords = {COPD,Mechanical Ventilation,Weaning}, url = {https://zumj.journals.ekb.eg/article_45686.html}, eprint = {https://zumj.journals.ekb.eg/article_45686_73a05f32a012da595bef3806c978242d.pdf} } @article { author = {abdullah, shimaa and Elsafy, usama and Abdel Moniem, Ahmed}, title = {Frequency of H.Pylori Infection With Correlation To Anthropometric Measures In Children Aged (2-12) years In Zagazig University Hospital}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {735-745}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.14292.1303}, abstract = {AbstractBackground: H. pylori infection is the most common microbial infection in the world. It has a long history of a relationship with individuals, so the accurate and early diagnosis of H. pylori infection is a relevant problem. H. pylori stool antigen test is a reliable, very good, and reasonably priced screening test for H. pylori infection, both before and after eradication that could identify foreign proteins (antigens) in stool samples that are related with H. pylori infection. Therefore, this test has been proposed for the diagnosis of infection. Objective: This study aimed to evaluate the frequency of H. pylori infection and its correlation to anthropometric measures in children aged (2-12) years in pediatric outpatient clinic in Zagazig University Hospital. Methods: This cross sectional study comprised67 children their ages were from two to twelve years. H. pylori stool antigen test was done for all children recruited in this study, by a microplate-based ELISA assay. Results: Among studied group, a total of 36 children (53.7%) had positive H. pylori stool antigen test who suffered from gastro intestinal symptoms especially recurrent abdominal pain. There was no statistically significant difference between H. pylori +ve &H. pylori –ve infected children as regarding all the anthropometric measures. H. pylori infection was correlated with abdominal distension.Conclusion: frequency of H. pylori infection in children still high and a prevalent condition .We need further studies in this subject. H. pylori infection did not affect growth.}, keywords = {Keywords: H. pylori,Diagnosis,Growth}, url = {https://zumj.journals.ekb.eg/article_45939.html}, eprint = {https://zumj.journals.ekb.eg/article_45939_83005488a3685c3e05c04cf150f08cfe.pdf} } @article { author = {Mosbah, Hassan and shedeed, soad and Tolba, sabry}, title = {Speckle Tracking Echocardiographic Ventricular Functions In Infants With Pulmonary Hypertension With Shunt Disease}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {690-699}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.11098.1147}, abstract = {Background: Pulmonary arterial hypertension (PAH) is a major complication of congenital heart disease (CHD), it occurs in patients with congenital cardiac shunts with increased morbidity and mortality. Objectives: This study carried to assess the left and right ventricular functions and the strain pattern among infants with pulmonary hypertension associated with shunt disease by 2-D speckle tracking echocardiography and correlate these finding with haemoynamic, clinical and echocardiographic findings among such patients. Patients & Methods: This study was carried out at the Pediatric Cardiology Unit, Pediatric Department, Zagazig University Hospital, during the period from June 2018 till February 2019. Results: In our study, it was found that Pulmonary artery systolic pressure values among infant with pulmonary hypertension with shunt is a strong positive predictors of Average LV Circumferential strain value. There was a statistical significant difference between patients with moderate and severe pulmonary hypertension as regard their RVGLS. Conclusions: Two-dimensional speckle-tracking echocardiography is considered non-invasive tool for right and left ventricular function evaluation in children with pulmonary arterial hypertension, allowing analysis of both global and segmental (longitudinal and circumferential) assessment of ventricular myocardial deformation.}, keywords = {Speckle Tracking Echocardiographic,Ventricular Functions,pulmonary hypertension,Shunt Disease}, url = {https://zumj.journals.ekb.eg/article_46125.html}, eprint = {https://zumj.journals.ekb.eg/article_46125_d8a6db33d97ab3b76d3c0eae096bfe29.pdf} } @article { author = {shaban, shimaa and Albalat, Waleed and ElGarf, Ahmed}, title = {" The effect of Platelet Rich Plasma injection in treatment of Androgenetic alopecia patients "}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {746-752}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.14509.1311}, abstract = {AbstractBackground: Androgenetic alopecia (AGA) is an androgen-dependent, hereditary dermatological disorder , affecting men and women causing progressive thinning of the scalp hair in a defined Characteristic pattern, with significant negative impact on social and psychological state of patients. Aim of the work: To evaluate the efficacy and safety of Platelet Rich Plasma injection in androgenetic alopecia patients.Subjects and methods: A therapeutic trial study was carried out on a sample size of 20 patients with AGA who attended the outpatients' clinics of dermatology department - Zagazig University Hospitals.Results: At baseline, 16 patients (80%) had a positive pull test with a mean number of 9 hairs. At 4th and 8th week ,The hair loss decreased with a mean number of 5.5 and 3 hairs respectively . After PRP injection 2 patients (10%) achieved high improvement , 6 patients (30%) achieved moderate improvement , 6 patients (30%) achieved mild improvement and 6 patients (30%) achieved no change, with final patient’s satisfaction (40%). Conclusion: PRP injection is relatively effective in treatment of Androgenetic alopecia.Key words: Platelet rich plasma ; hereditary ; androgenetic alopecia}, keywords = {Key words: Platelet rich plasma,hereditary,androgenetic alopecia}, url = {https://zumj.journals.ekb.eg/article_46935.html}, eprint = {https://zumj.journals.ekb.eg/article_46935_e14cf76ff8871f6fa6cb52e283e4d8e3.pdf} } @article { author = {Abd elhamed Mohamed, Mohamed and arafa, ayman and anany metwaly, elsayed}, title = {The Relation between Hemoglobin Level Variability and Carotid Intima-Media Thickness in Chronic Hemodialysis Patients}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {869-876}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.13873.1267}, abstract = {Background: Hemoglobin variability (HB), defined as hemoglobin value varying between low, normal and high levels, is a common condition among hemodialysis (HD) patients. Atherosclerotic lesions are highly prevalent in patients with chronic kidney disease (CKD). Carotid artery Intima-Media Thickness (CIMT) is noninvasive ultrasound test recommended to screen for heart diseaseAim: to evaluate the relation between Hemoglobin variability and CIMt among the studied patientsPatients and methods: A cross-sectional study was conducted on 70 patients on (HD) attending HD units in Internal Medicine Department in Zagazig University Hospitals and Al- Ahrar teaching hospital during the period from February 2018 to February 2019. Patients underwent history taking, clinical examination, and laboratory investigations. Efficiency of hemodialysis was calculated. CIMT is measured in B-mode ultrasound image using Doppler on carotid arteries.Results: A significant positive correlation is detected between hemoglobin change and both CIMT and total cholesterol. However, there is significant negative correlation between hemoglobin change and hematocrit level. A significant negative correlation is present between CIMT and hematocrit value, total protein and CRP. A significant positive correlation is present between CIMT and serum albumin, serum creatinine, BUN and total cholesterol. The best cutoff of hemoglobin variability in prediction of abnormal CIMT is ≥3.45, with sensitivity 86.7%, specificity 90.9%, positive predictive value 72.2%, negative predictive value 96.1% with accuracy 90% (p < /p>}, keywords = {Hemodialysis,Hemoglobin,variability}, url = {https://zumj.journals.ekb.eg/article_47318.html}, eprint = {https://zumj.journals.ekb.eg/article_47318_2cfb7dc4704d74308829da528dae571a.pdf} } @article { author = {Abdelhalim, Mohamed and Romih, Mohamed and El- Hindawy, Eman and Khalifa, Naglaa}, title = {Value of Pro-Adrenomedullin in Critically Ill Septic Children in Zagazig University Hospital}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {700-707}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.12310.1215}, abstract = {Introduction: Sepsis is a life-threatening condition which affects many children regardless of some underlying healthcare issues. Assessment risk of mortality in critically ill septic children in pediatric intensive care units (PICUs) can be done by measuring levels of certain new biomarkers. Adrenomedullin (ADM) has been recently proposed as a useful biomarker for evaluating disease severity and risk of death.Objective: The purpose of this study was to measure sensitivity and specificity of ADM in assessment risk of mortality in septic children in comparison to other traditionally used biomarkers in PICUs as CRP and procalcitonin.Method: A prospective Cross sectional study was carried out at pediatric intensive care unit of the pediatric Department and clinical pathology department at Zagazig University Children Hospitals during the period from July 2018 to January 2019 , Thirty eight infant and children patients were recruited in the study ,they were selected from the pediatric intensive care unit population who suffered septicemia ,blood samples withdrawn to measure sepsis markers as ADM , CRP and PCT.Results: There is statistically significant difference between the outcome of the studied patients and our biomarkers CRP, procalcitonin and ADM levels, we found that sensitivity of ADM 83.3%, specificity was 75% PCT sensitivity was 77.8% and specificity was 65% however 72.2% sensitivity, 65% specificity of CRP.Conclusion: MR-pro-ADM level have shown higher positive-predictive values than PCT and CRP levels with high sensitivity and specificity so , this study came to support MR-pro-ADM as new biomarker in critically ill septic children.}, keywords = {pediatric intensive care unit,Sepsis,MR-pro-ADM}, url = {https://zumj.journals.ekb.eg/article_48536.html}, eprint = {https://zumj.journals.ekb.eg/article_48536_8a6599fab4605e40f480f7371abc3e1f.pdf} } @article { author = {Elbanna, Ehab and Sarhan, Dina and ibrahim, salah and abd el aziz, tarek}, title = {Clinical Characterizations of Neonatal Admission in Neonatal Intensive Care Unit at Zagazig University Children Hospital}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {775-786}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.16984.1519}, abstract = {Background: The neonatal intensive care unit (NICU) has high-quality medical staff and tools to care for premature and sick term neonates. Epidemiological information regarding diseases, management and outcome of admitted neonates in NICU are the basis for establishing an effective intervention and adjusting the quality of health care.This study aimed to determine disease patterns, prescribed medications, resource utilization and outcome of the neonates hospitalized in NICU. Methods: Observational cross sectional study, which included 213 neonates admitted from May 2018 to January 2019, at NICUs of obstetric and children hospitals of Zagazig University. Perinatal and demographic data, diagnosis, prescribed medications and outcome were documented and analyzed.Results: The commonest primary diagnosis during NICU admission were RDS (21.1%) followed by surgical problems (14.6%), late onset sepsis (12.2%), congenital pneumonia (8.5%), early onset sepsis (8%) and aspiration pneumonia (5.2%).All of the studied neonates received antibiotics while (97.1%) received parenteral nutrition ,(30.1%) received positive inotropes and (28.6%) received caffeine citrate. As regard the outcome, (19.2%) of the studied neonates were died and the causes of neonatal deaths were sepsis (12.2%) followed by respiratory failure (5.1%), cardiogenic shock (2.8%), surgical complications (1.9%), inborn error of metabolism (IEM) (1%) and severe hypoxic ischemic encephalopathy (HIE) (0.5%).Conclusion: RDS and surgical diseases were the most common causes of NICU admission. The antibiotics and parenteral nutrition were prescribed frequently in NICU and sepsis was the main cause of newborn mortality.Key words: NICU, neonatal admission, neonatal mortality, Sepsis}, keywords = {NICU,neonatal admission,neonatal mortality,Sepsis}, url = {https://zumj.journals.ekb.eg/article_50956.html}, eprint = {https://zumj.journals.ekb.eg/article_50956_7b30da1e4f19691c63749182599871ff.pdf} } @article { author = {Mohamed, Amira and El-Saadawy, Mahmoud and Soliman, Naema and EL-shafei, Dalia}, title = {Relation between Job stress and Oxidative stress Biomarkers among Nurses in Zagazig University Hospitals}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {758-768}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.15216.1376}, abstract = {AbstractBackground: Nursing is highly demanding and stressful profession. Job stress was found to be a stronger predictor of oxidative stress activity causing elevation of blood oxidative biomarkers. Aim and objectives: This work aimed to improve mental and psychological health of nurses through identification of prevalence of job stress among nurses at Zagazig university hospitals (ZUHs) and assess its relation to blood oxidative biomarkers. Subjects and methods: A comparative cross-sectional study was conducted among 40 nurses and 40 administrative workers at ZUHs. Both two groups were subjected to a structured questionnaire about sociodemographic data and occupational history and two standardized questionnaires about job stress followed by laboratory investigations to measure blood oxidative biomarkers (Malonaldehyde MDA & Superoxide dismutase SOD). Results: this study showed that job stress and its level were significantly higher among nurses compared to their controls. this study indicated that prevalence of job stress in nurses at ZUHs was 85.0% compared to 22.5% in administrative controls where 65.0% and 20.0% of them had severe and moderate stress compared to 7.5% and 15.0% among controls. Furthermore, this study showed significantly high level of both blood oxidative biomarkers as both levels of MDA, [ Median (3.18) μmol/ml] and SOD, [X±SD: 4.27± 0.40 U/ml] were significantly higher among nurses compared to their controls Conclusion: Job stress is realistic and widespread phenomena among nurses in ZUHs that have devastating consequences on nurses health thus, effective preventive strategies should be designed and implemented.}, keywords = {Job stress,Blood Oxidative biomarkers,Nurses}, url = {https://zumj.journals.ekb.eg/article_52013.html}, eprint = {https://zumj.journals.ekb.eg/article_52013_aae41b14bb3bf7081a054ca18dd93a95.pdf} } @article { author = {Marei, Ayman and Boghdadi, Ghada and Tash, Rehab and Elgharabawy, Eman}, title = {Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {769-774}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.16153.1443}, abstract = {Background Despite existence of different therapeutic modalities, treatment of warts especially recalcitrant one remains a continuing challenge as there is no treatment modality exhibited high efficiency and low recurrence rate. Recently, intralesional immunotherapy via different types of antigens has proved high efficacy in the treatment of different types of warts.Objective To evaluate the efficacy and safety of intralesional Candida antigen in treatment of recalcitrant warts.Methods The study included 24 patients with recalcitrant warts. All patients were injected with 0.2 ml of 1/1000 solution of C. albicans antigen at 2-week intervals until complete clearance or for a maximum of six treatment sessions. Follow-up was done every month for six months to detect any recurrence.Results 14 patients (58.3%) showed complete response, 6 patients (25%) showed partial response and 4 patients (16.7%) showed no response with no change in warts size throughout treatment sessions. Adverse effects were insignificant and no recurrence of warts was detected.Conclusion Intralesional Candida antigen immunotherapy is a safe, promising and effective treatment modality for recalcitrant warts.}, keywords = {Candida antigen,Immunotherapy,recalcitrant warts}, url = {https://zumj.journals.ekb.eg/article_52216.html}, eprint = {https://zumj.journals.ekb.eg/article_52216_b06a4fdcb5041560aeb60eb20aa2d4e4.pdf} } @article { author = {nosair, asmaa and ismail, waleed and Hamed, Emad and Salem, Ghada}, title = {Health-related quality of life in Egyptian patients with chronic hepatitis C before and after treatment with direct acting antivirals}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {877-882}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.13982.1278}, abstract = {Background: According to World Health Organization (WHO) estimates, the prevalence of HCV in Egypt is 4.5% to 6.7%, which is the uppermost prevalence of HCV in the world causing a substantial burden of mortality and morbidity. Health related quality of life [HRQoL] has been assessed in diabetes, arthritis and a wide variety of cancers, Until now, there is no sufficient report about HRQoL related to direct acting antiviral agents (DAAs )on Egyptian patients with chronic HCV. This prospective cohort study aimed to assess the health related quality of life in Egyptian patients with chronic HCV treated with daclatasvir (DAC) and sofosbuvir(SOF) ± ribavirin (RBV). Methods: One hundred HCV patients were classified according to the supreme council and national committee for control of HCV (NCCVH) into two groups: Group 1 (easy to treat) included 35 patients treated with SOF+DAC for 12 weeks, and group 2 (difficult to treat) included 65 patients treated with SOF+DAC+RBV for 12 weeks. The short form 36 scale (SF-36) was used to assess the health related quality of life in two groups. Results: Sustained virological response (SVR12) in patient received DAC/SOF was 83.3 % and in patient received DAC/SOF/RBV was 100% (Total 93%). The patients reported significant improvement in all HRQoL domains after therapy, group1reported higher improvement. Conclusion: Sofosbuvir and Daclatasvir with or without ribavirin are effective in treatment of chronic HCV infections with low adverse actions and better improvement in HRQoL. Sofosbuvir and Daclatasvir have better improvement in HRQoL than Sofosbuvir and Daclatasvir plus ribavirin.}, keywords = {HCV,Daclatasvir,Sofosbuvir,Health related quality of life,SF-36 scale}, url = {https://zumj.journals.ekb.eg/article_52598.html}, eprint = {https://zumj.journals.ekb.eg/article_52598_dad7c16e8321acebf29adf9cb1a3fb38.pdf} } @article { author = {Assy, Mostafa and Dawood, Haitham and khamis, mai}, title = {The value of ultrasound in preoperative diagnosis of traumatic nerve injuries in forearm and hand.}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {853-861}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2019.19002.1612}, abstract = {OBJECTIVE:This study aimed to detect the role of ultrasound (US) in preoperative diagnosis of traumatic nerve injuries in the forearm and hand and correlation with operative findings.PATIENTS AND METHODS:Thirty patients (30) with thirty one (31) traumatic median, ulnar and radial nerve injuries in forearm and hand were evaluated by ultrasound. All patients underwent surgical exploration and the sonographic findings were compared with the surgical data. RESULTS:Neuroma in-continuity was the most common US finding found in fourteen (14) injured nerves (45.2%). Followed by complete tear found in seven (7) injured nerves (22.6%). Incomplete tear is the least common findings found only in two (2) injured nerves (6.5%) The preoperative US findings in our study had agreed with intra-operative data in twenty nine (29) out of thirty one (31) injured nerves (93.5%).CONCLUSION:Ultrasonography provides an economical and accurate imaging modality that can be utilized in diagnosis, assessment and treatment planning of traumatic peripheral nerve injuries.}, keywords = {KEYWORDS: Ultrasonography (US),positive predictive value (PPV),negative predictive value (NPV)}, url = {https://zumj.journals.ekb.eg/article_64464.html}, eprint = {https://zumj.journals.ekb.eg/article_64464_ee8bfd99635126940903703fd89dbcf7.pdf} } @article { author = {Assy, Mostafa and Nasr, Ahmed and Shebl, Mohamed and Dawood, Haitham}, title = {PULMONARY HEMORRHAGE AFTER PERCUTANEOUS TRANSTHORACIC CT-GUIDED CORE NEEDLE BIOPSY: ASSESSMENT OF THE RISK FACTORS.}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {787-794}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2020.21172.1656}, abstract = {Objective: the aim of this study is to assess the severity and risk factors associated with pulmonary hemorrhage complicating percutaneous transthoracic CT-guided core needle biopsy. Patient and Methods: this retrospective study was approved by our scientific and ethical committee. A total of 312 CT-guided lung biopsies done from December 2016, to September 2019 were included in this study. Pulmonary hemorrhage was assessed for each procedure. The severity of pulmonary hemorrhage was categorized into Grade 0 defined as no pulmonary hemorrhage, grade 1 as needle tract hemorrhage 2 cm or less, grade 2 as hemorrhage more than 2 cm, grade 3 as lobar hemorrhage or greater, and grade 4 as hemothorax. Grade 2 or higher was considered as high grade hemorrhage. Results: Pulmonary hemorrhage occurred 97(31%) out of the 312 after lung core biopsies. Grade I hemorrhage occur after 57 (18.3%) procedures, grade II after 37 (11.8%) procedures, grade III after 2 (0.6%) procedures and grade IV occur only after one procedure (0.3%). Grade II and more hemorrhage occur after 40 (13%) procedures and were considered as high grade hemorrhage. High grade hemorrhage was statistically significant to occur more with female sex, lesions less than 3 cm, non-subpleural location and co-axial technique (P ˂0.05). Emphysema and age were not a significant risk factor for high grade hemorrhage (P >0.05). Conclusion: pulmonary hemorrhage complicating CT-guided core needle lung biopsy is common. Significant risk factors associated high grade hemorrhage includes female sex, lesions less than 3 cm, non-subpleural location and co-axial technique.}, keywords = {Keywords: CT (computed tomography),pulmonary,percutaneous,core biopsy}, url = {https://zumj.journals.ekb.eg/article_67831.html}, eprint = {https://zumj.journals.ekb.eg/article_67831_08b74c8116e710fe683e5477217d8c4f.pdf} } @article { author = {Alhaj, Ali}, title = {Occupational Lead Exposure among Petrol Station Workers in Sana’a City, Yemen: Awareness and Self-Reported Symptoms}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {795-805}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2020.20291.1633}, abstract = {Background: This study assessed the awareness of occupational lead exposure risks, self-reported lead poisoning symptoms and work practices and using personal protective equipment among petrol station workers in Sana'a city, Yemen.Subjects and methods: A cross-sectional study was conducted among 172 petrol station workers in nine districts of Sana'a between January and May 2017. Data about demographic characteristics, awareness of the lead exposure risks, self-reported lead poisoning symptoms and work practices and use of personal protective equipment were collected. Inclusion criteria were workers who gave informed consent to participate, were aged 18-60 years and had been working for ≥6 months. The data were then analyzed using appropriate statistical tests. Results: The majority of workers were aware of the adverse health effects of leaded petrol (61.0%) and that lead is an environmental pollutant (60.5%). However, personal protective equipment was poorly used. Workers with secondary education and above had better practices than those with primary education. Approximately 76.2% of workers had poor knowledge of lead risks, and 13.4% of them had good practices. The most common self-reported symptoms were neurological, including fatigue (68.0%), concentration difficulties (61.6%), joint pain (58.1%) and headache (55.2%). Conclusions: Petrol station workers in Sana’a realize the exposure to lead risks because leaded petrol is the fuel type used in the country. Although the majority of workers perceived such adverse health effects, use of personal protective equipment was poor among most of them. The level of workers’ education seems to influence their practices of using personal protective equipment.}, keywords = {Lead,Awareness,Self- reported symptoms,Petrol station worker,Yemen}, url = {https://zumj.journals.ekb.eg/article_80311.html}, eprint = {https://zumj.journals.ekb.eg/article_80311_f3ff00fbd1575aab48c4e34f0f42a74d.pdf} } @article { author = {Nassar, Mogahid and Hudna, Ahmed and Alhaj, Ali and Alqubaty, Abdulhabib and Alqahtani, Talal}, title = {Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen}, journal = {Zagazig University Medical Journal}, volume = {26}, number = {5}, pages = {806-813}, year = {2020}, publisher = {Zagazig University, Faculty of Medicine}, issn = {1110-1431}, eissn = {2357-0717}, doi = {10.21608/zumj.2020.32403.1876}, abstract = {Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inborn enzymatic defect in the world. Determining the prevalence of G6PD deficiency is an essential step towards evaluating its impact on the health of a population. Therefore, this study aimed to determine the prevalence and factors associated with G6PD deficiency among newborns in Sana’a city, Yemen. Subjects and methods: This cross-sectional study included 397 newborns from eight public and private hospitals in Sana’a city in the period from January to March 2020. Data about gender and the factors possibly associated with G6PD deficiency were collected using a pre-designed questionnaire. G6PD deficiency was qualitatively detected in fresh blood using rapid diagnostic tests (RDTs). Data were analyzed using SPSS software, and differences were considered statistically significant at p-value}, keywords = {Newborns,G6PD deficiency,Rapid diagnostic test,Yemen}, url = {https://zumj.journals.ekb.eg/article_100435.html}, eprint = {https://zumj.journals.ekb.eg/article_100435_ce1b73aee0d1284beecd96a2f732406f.pdf} }