ORIGINAL_ARTICLE
THE IMPACT OF MATERNAL OBESITY ON MOTHER AND NEONATAL HEALTH: AC0HORT STUDY IN ZAGAZIG UNIVERSITY HOSPITALS
Background: Obesity would increase the possibility of unfavorable effects on maternal and fetal outcomes. So, it is important to investigate the relationship between maternal obesity and its possible effects and determinants. Subject & Methods: A cohort study was conducted on 104 pregnant women at the 3rd trimester attending antenatal clinic of zagazig university hospital for routine antenatal care. Data was collected by semi-structured interview, follow up sheet in the 3rd trimester, as well as labor, and delivery sheets and neonatal assessment sheet. Results: Findings of the study revealed that, women aged ≥ 30 years old tend to be obese (p = 0.005). Multipara has 3 times risk of obesity (Relative risk (RR) = 3.0, 95 % Confidence Interval (CI) = 2.27-15.0) than primipara. Obese women had 2 times risk to have miscarriage than non-obese (RR =2.2, 95 % CI = 1.18-8.21). Obese pregnant women were liable to pregnancy complication such as gestational hypertension, gestational diabetes and preeclampsia (p = 0.03). Also they had 6 times risk to have cesarean delivery (RR =5.5, 95 % CI = 1.17-3.55) than non-obese women. Fetal macrosomia are more common among babies born to obese mothers (p < /p>
https://zumj.journals.ekb.eg/article_33117_935c3264fe1ebc29cbb3c6983296aea5.pdf
2020-09-01
832
839
10.21608/zumj.2019.11615.1198
Maternal obesity
Pregnancy complications
fetal macrosomia and APGAR scoring
Nashwa
mohammed ashour
nashwa7@gmail.com
1
family medicine resident doctor,faculty of medicine, zagazig university
LEAD_AUTHOR
shereen
bahgat
drshereenbahgat@yahoo.com
2
lecturer of family medicine, faculty of medicine, zagazig university
AUTHOR
moustafa
zaiton
mostafazaiton54@hotmail.com
3
professor of obstetric and gynecology, faculty of medicine, zagazig university
AUTHOR
hosnia
ragab
dr_hosnia@hotmail.com
4
professor and head of public health and community medicine, faculty of medicine, zagazig university
AUTHOR
ORIGINAL_ARTICLE
Q192R PARAOXONASE 1 GENE POLYMORPHISM AMONG RHEUMATOID ARTHRITIS PATIENTS IN ZAGAZIG UNIVERSITY HOSPITALS
Background: Rheumatoid arthritis patients (RA) have expanded cardiovascular morbidness and death rate. Paraoxonase1 (PON1) polymorphism has been related to expanded cardiovascular hazard. Aim of the work: to assess the relationship between PON1 gene polymorphism and RA. Subjects and methods: A case control study was conducted in Rheumatology and Rehabilitation Department in cooperation with Medical Biochemistry and Biology Department, Zagazig University Hospitals on 106 subjects. They were divided randomly into case and control groups, full history was taken from all patients, also locomotor examination, laboratory and radiological evaluation were done. Genotyping of PON1 gene polymorphism was studied in both groups Results: Regarding PON1 polymorphism genotypes, the difference in PON1 genotypes frequency was not significant among RA patients and controls (P>0.05). Levels of total triglycerides, HDL and LDL were different significantly in both groups. Conclusion: Although RA patients had higher cardiovascular risk, PON1 Q192R polymorphism was not prominent in RA patients contrasted with controls.
https://zumj.journals.ekb.eg/article_36378_2f3ed4d391976baf5e81b86ffddfaf96.pdf
2020-09-01
862
868
10.21608/zumj.2019.12597.1223
Key words: Rheumatoid arthritis
PON1 polymorphism
cardiovascular risk
mona
Mohamed
mona_22785@yahoo.com
1
rheumatology and rehabilitation,faculty of medicine ,zagazig university,egypt
LEAD_AUTHOR
marwa
hammad
marwawahany22@hotmail.com
2
Rheumatology& Rehabilitation,faculty of medicine ,zagazig university,egypt
AUTHOR
essam
atwa
etawa958@gmail.com
3
Rheumatology& Rehabilitation,faculty of medicine ,zagazig university,egypt
AUTHOR
atef
hussein
atefgoda57@yahoo.com
4
medical biochemistry,faculty of medicine ,zagazig university,egypt
AUTHOR
ORIGINAL_ARTICLE
Percutaneous coronary intervention in chronic total coronary occlusions : Parameters of success
ABSTRACTBackgroud:chronic total coronary occlusions (CTOs) are the most technically challenging lesion that interventional cardiologists might face, and treatment of these lesions will have great effect on future percutaneous coronary intervention (PCI) success. Despite notable advances in the procedural and medical outcomes of percutaneous revascularization, CTO remains the unresolved problem in interventional cardiology.Objective: To detect the pre-interventional predictors for procedural success of PCI of CTO and assess improvement of Left ventricular ejection fraction after successful PCI of CTO.Methods: 52 Patients with CTO of more than 3 months duration having significant angina (Class III / IV) or recent acceleration of previously chronic stable angina admitted to zagazig university hospital and Kobry El-Kobba Military Hospital during period from januray 2017 till januray 2018 were included in the study. Results: Predictors of technical success in CTO intervention were coronary artery diameter > 3mm , short CTO length less than 20mm , tapered CTO stump, absence of calcificlesion , bending angle less than 45 degree and prescence of microchannels. While small coronary artery diameter >3mm, CTO length more than 20mm , presence of bridging collaterals and high J-CTO score were predictors of technical failure .Conclusion: PCI for coronary CTO should be performed for documented viable myocardium in the territory supplied by the chronicaly occluded artery. Proper evaluation of the clinical and angiographic characteristics of the patient to choose the proper plan for the recanalization. Success of PCI to CTO cause significant increase left ventricular ejection fraction.
https://zumj.journals.ekb.eg/article_37989_efc0d3b371a34f8c5b0de400e967ab43.pdf
2020-09-01
840
852
10.21608/zumj.2019.13606.1255
percutaneous coronary intervention
coronary total occlusions
Coronary Artery Bypass Graft
Ahmed
Mohamed Ahmed
omda2099@yahoo.com
1
Cardiology specialized hospital , kobry el kopa military medical compound
LEAD_AUTHOR
Ghada
mohamed ebrahim
ghada-ebrahim1@yahoo.com
2
cardiology department ,faculty of medicine, zagazig university
AUTHOR
Kamel
Mohamed ghazal
kamelghazal535@yahoo.com
3
Cardiology departement , faculty of medicine, zagazig university
AUTHOR
Mahmoud
El-Menshawy
diaa.heart@hotmail.com
4
Cardiology departement, faculty of medicine, zagazig university
AUTHOR
ORIGINAL_ARTICLE
CD34 Expression in Adult Acute Myeloid Leukemia is an Independent Poor Prognostic Factor
Background: CD34 is a marker of HSCs and haematopoietic progenitor cells as well as a marker of several other non-haematopoietic cell types. There is much debate on whether expression of CD34 on malignant myelogenous leukaemia blast cells affect the prognosis and response to treatment or not and if it is an independent prognostic factor or affected by other prognostic factors, especially the cytogenetics.Methods: This prospective study had been carried out at Haematology Unit, Zagazig University Hospitals. It included 90 denovo AML patients. CD 34 expression was identified by Flowcytometric studies of bone marrow aspirate. it was considered positive if a cut-off level of 10% expression was exceeded. This was then analysed to detect its impact on outcome and its correlation to other risk factors especially cytogenetics.Results: sixty (66.7%) of the AML patients were CD34 positive and their survival was shorter than patients with negative CD34 expression. CD34 positive AML cases had lower rate of achievement of complete remission. CD34 positivity was significantly linked to less differentiated FAB subtypes (M0, M1, and M2) as well as non-favorable risk cytogenetics. However, multivariate cox regression analysis proved that CD34 positivity confers an independent poor prognostic impact apart from its association with these poor risk factors.Conclusions: CD34 expression is a poor prognostic biomarker of survival in AML patients, independent from other poor prognostic factors. Its role in AML different subgroups layered by different gene mutations and chromosomal aberrations needs further extensive studying.
https://zumj.journals.ekb.eg/article_38329_8d6df310d3b87ba7a081760787eb11d3.pdf
2020-09-01
823
831
10.21608/zumj.2019.10047.1146
AML
CD34
prognosis
Cytogenetics
Ahmed
Amer
dr.ahmedbadwy@hotmail.com
1
24 Furness Avenue
LEAD_AUTHOR
ayman
Abdelhaleim
aymanjehan@yahoo.com
2
internal medicine,faculty of medicine,zagazig university
AUTHOR
hossam Eldin
Salah
hossamsalah.shab@hotmail.com
3
Zagazig university
AUTHOR
ORIGINAL_ARTICLE
Correlation between QRS Dispersion and Severity of Coronary Artery Disease Detected by GENSINI score in Patients with non ST Elevation Myocardial Infraction
Objective: The aim of the current study was to study the correlation of QRS dispersion with the severity of coronary artery lesion in patients with NSTEMI detected by GENSINI score (short term outcome). Methods: The whole study group included 96 (63 males and 33 females) patients presented with NSTEMI. Age ranged from 46 and 75 years with a mean of 57.4 ± 6.8. Table (7) summarizes clinical baseline and laboratory data of the studied patients. Results: study was include 96 consecutive patients whom were admitted to Cardiology Care Unit for NSTEMI in the period between Marsh to September 2018. The patients were informed with the necessary information of the study. Study was approved by the research ethical committee of Faculty of Medicine, Zagazig University, and a written informed consent was obtained from all participants (patients included 63 males and 33 females patients with their age ranged from 46 and 75 years with a mean of 57.4 ± 6.8) . Conclusion: In the current study, we found highly significant positive correlation between admission heart rate and maximum high-sensitive troponin T level and Gensini score > 20 in the setting of NSTEMI. A significant positive correlation between age, male gender, QRS measurements, QTc dispersion, LVESD and Grace score and Gensini score > 20 was found in the setting of NSTEMI. There was a negative significant correlation between LVEF and Gensini score > 20.
https://zumj.journals.ekb.eg/article_41336_311db3974537c6bdda2a2da1077d5461.pdf
2020-09-01
814
822
10.21608/zumj.2019.7093.1015
QRS Dispersion
severity
Coronary Artery Disease
Gensini score
NSTEMI
rafiq
alshlbh
rafiqalshlbh2019@gmail.com
1
cardiology department, faculty of medicin, zagzig university
LEAD_AUTHOR
Abdelfatah
Mohamed
abdelfatah.frere@gmail.com
2
Professor of Cardiology, Faculty of Medicine - Zagazig University
AUTHOR
Montaser
Alcekelly
montaser.alcekelly@gmail.com
3
Professor of Cardiology, Faculty of Medicine - Zagazig University
AUTHOR
Ismail
Ibrahim
ismail.ibrahim@gmail.com
4
Lecturer of Cardiology, Faculty of Medicine - Zagazig University
AUTHOR
ORIGINAL_ARTICLE
Neuological Soft signs in euthymic bipolar I patients: State or trait markers.
Background: Neurological soft signs (NSS) are endphenotypic markers widely studied in schizophrenia, but few papers have focused on evaluating them in bipolar disorder (BP) and their first degree relatives.Objectives: the aim of this study was to determine the prevalence and scores of NSS in bipolar I patients in remission state compared to their healthy relatives and controls, in addition to explore correlation with some sociodemographic data and clinical features of these euthymic patients.Methods: The study was conducted on 30 euthymic bipolar 1 patients, 30 their healthy relatives and 30 control subjects. The neurological soft signs were assessed by the Neurological Evaluation scale (NES). Bipolar I. Euthymic patients were also assessed by young Mania rating scale (YMRS) and the Hamilton Depression rating scale (HDRS). All subjects were recruited from Zagazig university Hospital. A simple questionnaire was structured for all participants to collect some sociodemographic data.Results: NSS are prevalent in bipolar 1 euthymic patients and their first degree relatives, though significantly more in affected subjects.Conclusion: This suggests that NSS could be considered as trait marker supporting the theory that bipolar disorder may be a neurodevelopmental disorder.
https://zumj.journals.ekb.eg/article_42939_dde3ff6fcc989914e0cb9ede64ed8c35.pdf
2020-09-01
715
724
10.21608/zumj.2019.13938.1271
Neurological soft sign
Bipolar Disorder
euthymic patients
Ahmed
Reda Abd Ellatif
ahmed.rafeek.10@gmail.com
1
Neurosychiatry department at Police Hospitals , Ministry of interior, Egypt.
LEAD_AUTHOR
Eman
El Safy
e.roshdy_safy@hotmail.com
2
Professor of Psychiatry, Faculty of Medicine, Zagazig University, Egypt.
AUTHOR
Nagda
El Masry
nagdaelmasry@yahoo.com
3
Professor of Psychiatry, Faculty of Medicine, Zagazig University, Egypt.
AUTHOR
Amany
El-Shabrawy
ahmed2001go@yahoo.com
4
Assoc. Prof. of Psychiatry, Zagazig University
AUTHOR
ORIGINAL_ARTICLE
Airway pressure release ventilation in pediatric respiratory failure. Does it really work?
Background: Airway pressure release ventilation (APRV) is a novel mode of ventilation. It is a form of bi-level assisted ventilation using continuous positive airway pressure (CPAP) with periodic decrease in pressure, either to a lower CPAP pressure or to atmospheric pressure. Aim of the work: to assess the ability of the APRV mode to improve the oxygenation and the mortality in cases with respiratory failure. Subjects and methods: A clinical trial was conducted in Pediatric intensive care unit in Zagazig university children's hospital included 76 patient. They were selected after failure of conventional mechanical ventilation, all patients were subjected to full history taking and full physical examination, routine labs and serial Chest X-rays, serial arterial blood gases and serial follow up of the ventilator parameters were observed. Results: APRV showed significant improvement in PaO2/FiO2 ratio and O2 saturation. Conclusion: APRV showed promising gateway to the cases of respiratory failure who failed their chances on conventional mechanical ventilation. Future studies are needed to compare both modes to assess the superior of one to another.
https://zumj.journals.ekb.eg/article_43605_f4861c85a8546bb180484c07422ea7f5.pdf
2020-09-01
753
757
10.21608/zumj.2019.14885.1345
Airway pressure release ventilation
Respiratory failure
Pediatrics
Alaa
Nafea
alaasnafea@gmail.com
1
pediatrics,medicine,zagazig uiniversity,zagazig,egypt
LEAD_AUTHOR
dalia
abdellatif
drdalia2811@gmail.com
2
department of pediatrics, faculty of medicine, zagazig university , Zagazig , Egypt
AUTHOR
Ehab
Rasheed
bebo_rasheed65@yahoo.com
3
pediatrics,faculty of medicine,Zagazig university, Zagazig, sharkia
AUTHOR
ORIGINAL_ARTICLE
ASSESSMENT of BLOOD MANGANESE CONCENTRATION IN CHILDREN WITH IRON DEFICIENCY ANEMIA
Abstract: Anemia is a global health problem, which affects not only developing countries, but also developed countries as well. Iron deficiency affects about 30% of the world’s population, making it one of the most prevalent nutritional problems worldwide. A nutritional iron deficiency may cause high absorption of Mn. Overexposure to Mn can cause an overwhelming neurologic impairment that is clinically called “manganism”. The aim of this study was to assess blood manganese concentration in children with iron deficiency anemia. Patients and methods: This is a prospective cohort study carried out in department of Pediatrics, faculty of medicine, Zagazig University, in a 6 months duration, on 50 children with iron deficiency anemia. CBC, ferritin and TIBC are used for diagnosis of iron deficiency anemia. Assessment of manganese levels was done with division of patients into normal and high manganese level.Result: most cases of iron deficiency anemia associated with increase blood manganese level.Conclusion: Blood manganese concentration is elevated in children with iron deficiency anemia.
https://zumj.journals.ekb.eg/article_45317_2d73014ce6a31413f1ee8174f8b1728b.pdf
2020-09-01
708
714
10.21608/zumj.2019.13492.1248
iron deficiency anemia
Manganese
iron
transferrin
asmaa
ahmed
drasmaa.ibrahim90@gmail.com
1
M.B.B.CH,Resident of Pediatrics
Faculty of Medicine, Zagazig University, Egypt
LEAD_AUTHOR
nahed
helmy khater
dr.nahed.khater@gmail.com
2
Professor of Pediatrics, Faculty of Medicine, Zagazig University, Egypt
AUTHOR
nehad
karam
nehadahmedkaram@hotmail.com
3
Professor of Pediatrics Faculty of Medicine, Zagazig University, Egypt
AUTHOR
ORIGINAL_ARTICLE
Cross sectional study to assess Malnutrition and associated risk factors among primary school children in Kafr Sakr, Sharqia, Egypt
ABSTRACTBackground: Malnutrition is considered a global health burden mainly in the developing countries, because of the high prevalence and it's undesirable consequences on health. Objective: Assessment of the nutritional status of school age children and its associated risk factors. Subject and methods: A cross-sectional study conducted among 341 primary school children aged (6-12) years in Kafr Sakr district, Sharqia governorate, Egypt. The assessment done by filling questionnaire about socio-demographic data, clinical examination, laboratory tests for hemoglobin detection and stool examination for all children. Results: The prevalence of stunting and underweight was 21.4% and 21.9% respectively. Anemia prevalence was 53.1% , parasitosis prevalence was 32.8%, while hair lice prevalence was 10.9%. The results revealed that stunting was significantly associated with underweight, parasitosis and low socioeconomic class. Underweight was significantly associated with anemia, parasitosis and low socioeconomic class. Conclusion and Recommendations: The present study results showed high malnutrition prevalence among primary school children which is significantly associated with anemia and parasitosis. So, we recommend emphasizing the importance of screening program of anemia and parasitosis with focus on school children.
https://zumj.journals.ekb.eg/article_45318_a4a5114d59e5974873156a63286f6bfd.pdf
2020-09-01
725
734
10.21608/zumj.2019.14033.1284
Keywords: Malnutrition
Anemia
parasitosis
Reham
Mansour
rehamelsayed518@gmail.com
1
Family medicine, faculty of medicine, Zagazig Univercity
LEAD_AUTHOR
Ali
Abu Zeid
shaimaaa29@gmail.com
2
Professor of Pediatric medicine,faculty of medicine,Zagazig University
AUTHOR
Rasha
Bahaa El Din
rasha_bhaa@yahoo.com
3
Lecturer of Family medicine, Faculty of Medicine, Zagazig University
AUTHOR
ORIGINAL_ARTICLE
Assessment of Weaning Practice In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients at Respiratory Intensive Care Unit of Zagazig University Hospitals
Background:Chronic obstructive pulmonary disease is a significant disease which can affect public health and classified as 3rd cause of death ,and described as a preventable and treatable disease associated with air flow limitation which is not completely reversible.40% to 50% of the duration of the mechanical ventilation (MV) support period can be spent in weaning.So the target of this study to evaluate weaning practice in mechanically ventilated patients with COPD disease due to acute exacerbation.Subjects and Methods: 24 COPD patients admitted to the ICU due to hypercapnic respiratory failure and who required invasive positive pressure mechanical ventilatory support were eligible for enrollment. After the acute phase, all eligible patients were subjected to an initial weaning trial.Results: As regard previous history of ventilator support and source of referral there was statistically non significant difference between the patients who failed and succeed weaning. As regard ventilator machine trade name there was statistically non significant difference for weaning success. There was statistically non-significant difference for weaning success regarding diaphragmatic ultrasound parameters (TDI, End inspiratory TDI and end expiratory TDI), but regarding diaphragmatic excursion there was significant difference. As regard Pi max and PaO2/FiO2 there was statistically significant difference for weaning success but regarding rapid shallow breathing index (RSBI) there was statistically non-significant difference. There was statistically non-significant difference for weaning success as regard method of weaning.Conclusion: Weaning success is very high in specialized tertiary ICU; 91.7%. Pimax, PaO2/ FIO2 and diaphragmatic excursion are a good predictor for weaning success.
https://zumj.journals.ekb.eg/article_45686_73a05f32a012da595bef3806c978242d.pdf
2020-09-01
883
891
10.21608/zumj.2019.15367.1377
COPD
Mechanical Ventilation
Weaning
Mohamed
Awad
mohamed_awad266@yahoo.com
1
Chest department, faculty of medicine,zagazig university, zagazig, Egypt.
AUTHOR
Waheed
Shouman
shouman66@yahoo.com
2
Chest department, faculty of medicine, zagazig university, zagazig, Egypt.
AUTHOR
Mohamed
Farouk
mohamedhassanba573@gmail.com
3
Chest department,faculty of medicin,zagazig university, Zagazig,Egypt
LEAD_AUTHOR
Abeer
Elhawary
dr_abeer72@yahoo.com
4
Chest department, faculty of medicin,zagazig university, zagazig, Egypt
AUTHOR
ORIGINAL_ARTICLE
Frequency of H.Pylori Infection With Correlation To Anthropometric Measures In Children Aged (2-12) years In Zagazig University Hospital
AbstractBackground: H. pylori infection is the most common microbial infection in the world. It has a long history of a relationship with individuals, so the accurate and early diagnosis of H. pylori infection is a relevant problem. H. pylori stool antigen test is a reliable, very good, and reasonably priced screening test for H. pylori infection, both before and after eradication that could identify foreign proteins (antigens) in stool samples that are related with H. pylori infection. Therefore, this test has been proposed for the diagnosis of infection. Objective: This study aimed to evaluate the frequency of H. pylori infection and its correlation to anthropometric measures in children aged (2-12) years in pediatric outpatient clinic in Zagazig University Hospital. Methods: This cross sectional study comprised67 children their ages were from two to twelve years. H. pylori stool antigen test was done for all children recruited in this study, by a microplate-based ELISA assay. Results: Among studied group, a total of 36 children (53.7%) had positive H. pylori stool antigen test who suffered from gastro intestinal symptoms especially recurrent abdominal pain. There was no statistically significant difference between H. pylori +ve &H. pylori –ve infected children as regarding all the anthropometric measures. H. pylori infection was correlated with abdominal distension.Conclusion: frequency of H. pylori infection in children still high and a prevalent condition .We need further studies in this subject. H. pylori infection did not affect growth.
https://zumj.journals.ekb.eg/article_45939_83005488a3685c3e05c04cf150f08cfe.pdf
2020-09-01
735
745
10.21608/zumj.2019.14292.1303
Keywords: H. pylori
Diagnosis
Growth
shimaa
abdullah
shymaashemais@gmail.com
1
pediatric-medicine-zagazig university-zagazig-Egypt
LEAD_AUTHOR
usama
Elsafy
usamasafy@gmail.com
2
pediatric-medicine-zagazig university-zagazig-Egypt
AUTHOR
Ahmed
Abdel Moniem
dr.ahmedemam_2006@yahoo.com
3
pediatric-medicine-zagazig university-zagazig-Egypt
AUTHOR
ORIGINAL_ARTICLE
Speckle Tracking Echocardiographic Ventricular Functions In Infants With Pulmonary Hypertension With Shunt Disease
Background: Pulmonary arterial hypertension (PAH) is a major complication of congenital heart disease (CHD), it occurs in patients with congenital cardiac shunts with increased morbidity and mortality. Objectives: This study carried to assess the left and right ventricular functions and the strain pattern among infants with pulmonary hypertension associated with shunt disease by 2-D speckle tracking echocardiography and correlate these finding with haemoynamic, clinical and echocardiographic findings among such patients. Patients & Methods: This study was carried out at the Pediatric Cardiology Unit, Pediatric Department, Zagazig University Hospital, during the period from June 2018 till February 2019. Results: In our study, it was found that Pulmonary artery systolic pressure values among infant with pulmonary hypertension with shunt is a strong positive predictors of Average LV Circumferential strain value. There was a statistical significant difference between patients with moderate and severe pulmonary hypertension as regard their RVGLS. Conclusions: Two-dimensional speckle-tracking echocardiography is considered non-invasive tool for right and left ventricular function evaluation in children with pulmonary arterial hypertension, allowing analysis of both global and segmental (longitudinal and circumferential) assessment of ventricular myocardial deformation.
https://zumj.journals.ekb.eg/article_46125_d8a6db33d97ab3b76d3c0eae096bfe29.pdf
2020-09-01
690
699
10.21608/zumj.2019.11098.1147
Speckle Tracking Echocardiographic
Ventricular Functions
pulmonary hypertension
Shunt Disease
Hassan
Mosbah
drhassan824@gmail.com
1
Department of pediatrics, Faculty of medicine, Zagazig University, Zagazig , Egypt.
LEAD_AUTHOR
soad
shedeed
soadshedeed@gmail.com
2
Professor of Pediatrics, Faculty of Medicine – Zagazig University
AUTHOR
sabry
Tolba
sabryelshobary@gmail.com
3
Lecturer of Pediatrics, Faculty of Medicine - Zagazig University
AUTHOR
ORIGINAL_ARTICLE
" The effect of Platelet Rich Plasma injection in treatment of Androgenetic alopecia patients "
AbstractBackground: Androgenetic alopecia (AGA) is an androgen-dependent, hereditary dermatological disorder , affecting men and women causing progressive thinning of the scalp hair in a defined Characteristic pattern, with significant negative impact on social and psychological state of patients. Aim of the work: To evaluate the efficacy and safety of Platelet Rich Plasma injection in androgenetic alopecia patients.Subjects and methods: A therapeutic trial study was carried out on a sample size of 20 patients with AGA who attended the outpatients' clinics of dermatology department - Zagazig University Hospitals.Results: At baseline, 16 patients (80%) had a positive pull test with a mean number of 9 hairs. At 4th and 8th week ,The hair loss decreased with a mean number of 5.5 and 3 hairs respectively . After PRP injection 2 patients (10%) achieved high improvement , 6 patients (30%) achieved moderate improvement , 6 patients (30%) achieved mild improvement and 6 patients (30%) achieved no change, with final patient’s satisfaction (40%). Conclusion: PRP injection is relatively effective in treatment of Androgenetic alopecia.Key words: Platelet rich plasma ; hereditary ; androgenetic alopecia
https://zumj.journals.ekb.eg/article_46935_e14cf76ff8871f6fa6cb52e283e4d8e3.pdf
2020-09-01
746
752
10.21608/zumj.2019.14509.1311
Key words: Platelet rich plasma
hereditary
androgenetic alopecia
shimaa
shaban
shaimaa1989a@gmail.com
1
Dermatology and Andrology, faculty of medicine , zagazig university , Zagazig , Egypt
LEAD_AUTHOR
Waleed
Albalat
waleedalbalat@hotmail.com
2
Dermatolgy
AUTHOR
Ahmed
ElGarf
dr_a.elgarf@yahoo.com
3
Dermatology and Andrology , faculty of medicine , Zagazig University , Zagazig , Egypt
AUTHOR
ORIGINAL_ARTICLE
The Relation between Hemoglobin Level Variability and Carotid Intima-Media Thickness in Chronic Hemodialysis Patients
Background: Hemoglobin variability (HB), defined as hemoglobin value varying between low, normal and high levels, is a common condition among hemodialysis (HD) patients. Atherosclerotic lesions are highly prevalent in patients with chronic kidney disease (CKD). Carotid artery Intima-Media Thickness (CIMT) is noninvasive ultrasound test recommended to screen for heart diseaseAim: to evaluate the relation between Hemoglobin variability and CIMt among the studied patientsPatients and methods: A cross-sectional study was conducted on 70 patients on (HD) attending HD units in Internal Medicine Department in Zagazig University Hospitals and Al- Ahrar teaching hospital during the period from February 2018 to February 2019. Patients underwent history taking, clinical examination, and laboratory investigations. Efficiency of hemodialysis was calculated. CIMT is measured in B-mode ultrasound image using Doppler on carotid arteries.Results: A significant positive correlation is detected between hemoglobin change and both CIMT and total cholesterol. However, there is significant negative correlation between hemoglobin change and hematocrit level. A significant negative correlation is present between CIMT and hematocrit value, total protein and CRP. A significant positive correlation is present between CIMT and serum albumin, serum creatinine, BUN and total cholesterol. The best cutoff of hemoglobin variability in prediction of abnormal CIMT is ≥3.45, with sensitivity 86.7%, specificity 90.9%, positive predictive value 72.2%, negative predictive value 96.1% with accuracy 90% (p < /p>
https://zumj.journals.ekb.eg/article_47318_2cfb7dc4704d74308829da528dae571a.pdf
2020-09-01
869
876
10.21608/zumj.2019.13873.1267
Hemodialysis
Hemoglobin
variability
Mohamed
Abd elhamed Mohamed
mohamedatef17102013@gmail.com
1
Internal medicine..alahrar teaching hospital
LEAD_AUTHOR
ayman
arafa
aymanjehan@yahoo.com
2
internal medicine,faculty of medicine,zagazig university
AUTHOR
elsayed
anany metwaly
elsayed.anany@yahoo.com
3
internal medicine,facultyof medicine,zagazig university
AUTHOR
ORIGINAL_ARTICLE
Value of Pro-Adrenomedullin in Critically Ill Septic Children in Zagazig University Hospital
Introduction: Sepsis is a life-threatening condition which affects many children regardless of some underlying healthcare issues. Assessment risk of mortality in critically ill septic children in pediatric intensive care units (PICUs) can be done by measuring levels of certain new biomarkers. Adrenomedullin (ADM) has been recently proposed as a useful biomarker for evaluating disease severity and risk of death.Objective: The purpose of this study was to measure sensitivity and specificity of ADM in assessment risk of mortality in septic children in comparison to other traditionally used biomarkers in PICUs as CRP and procalcitonin.Method: A prospective Cross sectional study was carried out at pediatric intensive care unit of the pediatric Department and clinical pathology department at Zagazig University Children Hospitals during the period from July 2018 to January 2019 , Thirty eight infant and children patients were recruited in the study ,they were selected from the pediatric intensive care unit population who suffered septicemia ,blood samples withdrawn to measure sepsis markers as ADM , CRP and PCT.Results: There is statistically significant difference between the outcome of the studied patients and our biomarkers CRP, procalcitonin and ADM levels, we found that sensitivity of ADM 83.3%, specificity was 75% PCT sensitivity was 77.8% and specificity was 65% however 72.2% sensitivity, 65% specificity of CRP.Conclusion: MR-pro-ADM level have shown higher positive-predictive values than PCT and CRP levels with high sensitivity and specificity so , this study came to support MR-pro-ADM as new biomarker in critically ill septic children.
https://zumj.journals.ekb.eg/article_48536_8a6599fab4605e40f480f7371abc3e1f.pdf
2020-09-01
700
707
10.21608/zumj.2019.12310.1215
pediatric intensive care unit
Sepsis
MR-pro-ADM
Mohamed
Abdelhalim
mohamed.haleem@ymail.com
1
Faculty of Medicine, Zagazig University Hospitals, Department of Pediatrics Sharkia, Egypt
LEAD_AUTHOR
Mohamed
Romih
mromih@yahoo.com
2
Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia, Egypt
AUTHOR
Eman
El- Hindawy
eelhindawy@yahoo.com
3
Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia, Egypt
AUTHOR
Naglaa
Khalifa
naglaaalikhalifa@yahoo.com
4
Faculty of Medicine, Zagazig University, Department of Clinical Pathology, Sharkia, Egypt
AUTHOR
ORIGINAL_ARTICLE
Clinical Characterizations of Neonatal Admission in Neonatal Intensive Care Unit at Zagazig University Children Hospital
Background: The neonatal intensive care unit (NICU) has high-quality medical staff and tools to care for premature and sick term neonates. Epidemiological information regarding diseases, management and outcome of admitted neonates in NICU are the basis for establishing an effective intervention and adjusting the quality of health care.This study aimed to determine disease patterns, prescribed medications, resource utilization and outcome of the neonates hospitalized in NICU. Methods: Observational cross sectional study, which included 213 neonates admitted from May 2018 to January 2019, at NICUs of obstetric and children hospitals of Zagazig University. Perinatal and demographic data, diagnosis, prescribed medications and outcome were documented and analyzed.Results: The commonest primary diagnosis during NICU admission were RDS (21.1%) followed by surgical problems (14.6%), late onset sepsis (12.2%), congenital pneumonia (8.5%), early onset sepsis (8%) and aspiration pneumonia (5.2%).All of the studied neonates received antibiotics while (97.1%) received parenteral nutrition ,(30.1%) received positive inotropes and (28.6%) received caffeine citrate. As regard the outcome, (19.2%) of the studied neonates were died and the causes of neonatal deaths were sepsis (12.2%) followed by respiratory failure (5.1%), cardiogenic shock (2.8%), surgical complications (1.9%), inborn error of metabolism (IEM) (1%) and severe hypoxic ischemic encephalopathy (HIE) (0.5%).Conclusion: RDS and surgical diseases were the most common causes of NICU admission. The antibiotics and parenteral nutrition were prescribed frequently in NICU and sepsis was the main cause of newborn mortality.Key words: NICU, neonatal admission, neonatal mortality, Sepsis
https://zumj.journals.ekb.eg/article_50956_7b30da1e4f19691c63749182599871ff.pdf
2020-09-01
775
786
10.21608/zumj.2019.16984.1519
NICU
neonatal admission
neonatal mortality
Sepsis
Ehab
Elbanna
ehab_banna@yahoo.com
1
professor of Pediatrics, Faculty of Medicine, Zagazig University
AUTHOR
Dina
Sarhan
dinatawfek7@yahoo.com
2
Assistant professor of pediatrics, faculty of medicine, zagazig university.
AUTHOR
salah
ibrahim
salah24sms@gmail.com
3
Assistant professor of clinical pathology,faculty of medicine,zagazig university
AUTHOR
tarek
abd el aziz
tahammad@zu.edu.eg
4
assisstant lecturer of pediatrics,faculty of medicine,zagazig university
LEAD_AUTHOR
ORIGINAL_ARTICLE
Relation between Job stress and Oxidative stress Biomarkers among Nurses in Zagazig University Hospitals
AbstractBackground: Nursing is highly demanding and stressful profession. Job stress was found to be a stronger predictor of oxidative stress activity causing elevation of blood oxidative biomarkers. Aim and objectives: This work aimed to improve mental and psychological health of nurses through identification of prevalence of job stress among nurses at Zagazig university hospitals (ZUHs) and assess its relation to blood oxidative biomarkers. Subjects and methods: A comparative cross-sectional study was conducted among 40 nurses and 40 administrative workers at ZUHs. Both two groups were subjected to a structured questionnaire about sociodemographic data and occupational history and two standardized questionnaires about job stress followed by laboratory investigations to measure blood oxidative biomarkers (Malonaldehyde MDA & Superoxide dismutase SOD). Results: this study showed that job stress and its level were significantly higher among nurses compared to their controls. this study indicated that prevalence of job stress in nurses at ZUHs was 85.0% compared to 22.5% in administrative controls where 65.0% and 20.0% of them had severe and moderate stress compared to 7.5% and 15.0% among controls. Furthermore, this study showed significantly high level of both blood oxidative biomarkers as both levels of MDA, [ Median (3.18) μmol/ml] and SOD, [X±SD: 4.27± 0.40 U/ml] were significantly higher among nurses compared to their controls Conclusion: Job stress is realistic and widespread phenomena among nurses in ZUHs that have devastating consequences on nurses health thus, effective preventive strategies should be designed and implemented.
https://zumj.journals.ekb.eg/article_52013_aae41b14bb3bf7081a054ca18dd93a95.pdf
2020-09-01
758
768
10.21608/zumj.2019.15216.1376
Job stress
Blood Oxidative biomarkers
Nurses
Amira
Mohamed
amira.shawaly@yahoo.com
1
community and public health department ,faculty of medicine, zagazig university
LEAD_AUTHOR
Mahmoud
El-Saadawy
m.el-saadawy@yahoo.com
2
Community, Environmental and Occupational Medicine department, Faculty of Medicine, Zagazig University
AUTHOR
Naema
Soliman
naemaellaithy@yahoo.com
3
Community, Environmental and Occupational Medicine department, Faculty of Medicine, Zagazig University
AUTHOR
Dalia
EL-shafei
d_elshaf3y_mony@hotmail.com
4
Community, Environmental and Occupational Medicine department, Faculty of Medicine, Zagazig University
AUTHOR
ORIGINAL_ARTICLE
Efficacy of intralesional Candida antigen immunotherapy in treatment of recalcitrant warts.
Background Despite existence of different therapeutic modalities, treatment of warts especially recalcitrant one remains a continuing challenge as there is no treatment modality exhibited high efficiency and low recurrence rate. Recently, intralesional immunotherapy via different types of antigens has proved high efficacy in the treatment of different types of warts.Objective To evaluate the efficacy and safety of intralesional Candida antigen in treatment of recalcitrant warts.Methods The study included 24 patients with recalcitrant warts. All patients were injected with 0.2 ml of 1/1000 solution of C. albicans antigen at 2-week intervals until complete clearance or for a maximum of six treatment sessions. Follow-up was done every month for six months to detect any recurrence.Results 14 patients (58.3%) showed complete response, 6 patients (25%) showed partial response and 4 patients (16.7%) showed no response with no change in warts size throughout treatment sessions. Adverse effects were insignificant and no recurrence of warts was detected.Conclusion Intralesional Candida antigen immunotherapy is a safe, promising and effective treatment modality for recalcitrant warts.
https://zumj.journals.ekb.eg/article_52216_b06a4fdcb5041560aeb60eb20aa2d4e4.pdf
2020-09-01
769
774
10.21608/zumj.2019.16153.1443
Candida antigen
Immunotherapy
recalcitrant warts
Ayman
Marei
ayman1067@hotmail.com
1
Microbiology and Immunology Dept., Faculty of medicine, Zagazigig University
AUTHOR
Ghada
Boghdadi
boghdadighada@hotmail.com
2
Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University,
AUTHOR
Rehab
Tash
relsaid193@yahoo.com
3
Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University
AUTHOR
Eman
Elgharabawy
purity_2010@hotmail.com
4
Medical Microbiology and Immunology, Faculty of Medicine,Zagazig university
LEAD_AUTHOR
ORIGINAL_ARTICLE
Health-related quality of life in Egyptian patients with chronic hepatitis C before and after treatment with direct acting antivirals
Background: According to World Health Organization (WHO) estimates, the prevalence of HCV in Egypt is 4.5% to 6.7%, which is the uppermost prevalence of HCV in the world causing a substantial burden of mortality and morbidity. Health related quality of life [HRQoL] has been assessed in diabetes, arthritis and a wide variety of cancers, Until now, there is no sufficient report about HRQoL related to direct acting antiviral agents (DAAs )on Egyptian patients with chronic HCV. This prospective cohort study aimed to assess the health related quality of life in Egyptian patients with chronic HCV treated with daclatasvir (DAC) and sofosbuvir(SOF) ± ribavirin (RBV). Methods: One hundred HCV patients were classified according to the supreme council and national committee for control of HCV (NCCVH) into two groups: Group 1 (easy to treat) included 35 patients treated with SOF+DAC for 12 weeks, and group 2 (difficult to treat) included 65 patients treated with SOF+DAC+RBV for 12 weeks. The short form 36 scale (SF-36) was used to assess the health related quality of life in two groups. Results: Sustained virological response (SVR12) in patient received DAC/SOF was 83.3 % and in patient received DAC/SOF/RBV was 100% (Total 93%). The patients reported significant improvement in all HRQoL domains after therapy, group1reported higher improvement. Conclusion: Sofosbuvir and Daclatasvir with or without ribavirin are effective in treatment of chronic HCV infections with low adverse actions and better improvement in HRQoL. Sofosbuvir and Daclatasvir have better improvement in HRQoL than Sofosbuvir and Daclatasvir plus ribavirin.
https://zumj.journals.ekb.eg/article_52598_dad7c16e8321acebf29adf9cb1a3fb38.pdf
2020-09-01
877
882
10.21608/zumj.2019.13982.1278
HCV
Daclatasvir
Sofosbuvir
Health related quality of life
SF-36 scale
asmaa
nosair
asmaa_nosair@yahoo.com
1
post graduate in Internal Medicine department, Zagazig University.
LEAD_AUTHOR
waleed
ismail
waleed.fattah@yahoo.com
2
internal medicine department,faculty of medicine, zagazig university
AUTHOR
Emad
Hamed
emad_991970@yahoo.com
3
Internal Medicine department, Faculty of medicine,Zagazig university, Egypt
AUTHOR
Ghada
Salem
gadamaged2@gmail.com
4
Community and public health department faculty of medicine. Zagazig university
AUTHOR
ORIGINAL_ARTICLE
The value of ultrasound in preoperative diagnosis of traumatic nerve injuries in forearm and hand.
OBJECTIVE:This study aimed to detect the role of ultrasound (US) in preoperative diagnosis of traumatic nerve injuries in the forearm and hand and correlation with operative findings.PATIENTS AND METHODS:Thirty patients (30) with thirty one (31) traumatic median, ulnar and radial nerve injuries in forearm and hand were evaluated by ultrasound. All patients underwent surgical exploration and the sonographic findings were compared with the surgical data. RESULTS:Neuroma in-continuity was the most common US finding found in fourteen (14) injured nerves (45.2%). Followed by complete tear found in seven (7) injured nerves (22.6%). Incomplete tear is the least common findings found only in two (2) injured nerves (6.5%) The preoperative US findings in our study had agreed with intra-operative data in twenty nine (29) out of thirty one (31) injured nerves (93.5%).CONCLUSION:Ultrasonography provides an economical and accurate imaging modality that can be utilized in diagnosis, assessment and treatment planning of traumatic peripheral nerve injuries.
https://zumj.journals.ekb.eg/article_64464_ee8bfd99635126940903703fd89dbcf7.pdf
2020-09-01
853
861
10.21608/zumj.2019.19002.1612
KEYWORDS: Ultrasonography (US)
positive predictive value (PPV)
negative predictive value (NPV)
Mostafa
Assy
mostafa83assy@gmail.com
1
Department od Radiodiagnosis, Zagazig University, Zagazig, Egypt
LEAD_AUTHOR
Haitham
Dawood
ghysoma2@gmail.com
2
Department of Radiodiagnosis, Zagazig University, Zagazig, Egypt
AUTHOR
mai
khamis
maikhamis2@yahoo.com
3
radiodiagnosis department, faculty of human medicine, zagazig university
AUTHOR
ORIGINAL_ARTICLE
PULMONARY HEMORRHAGE AFTER PERCUTANEOUS TRANSTHORACIC CT-GUIDED CORE NEEDLE BIOPSY: ASSESSMENT OF THE RISK FACTORS.
Objective: the aim of this study is to assess the severity and risk factors associated with pulmonary hemorrhage complicating percutaneous transthoracic CT-guided core needle biopsy. Patient and Methods: this retrospective study was approved by our scientific and ethical committee. A total of 312 CT-guided lung biopsies done from December 2016, to September 2019 were included in this study. Pulmonary hemorrhage was assessed for each procedure. The severity of pulmonary hemorrhage was categorized into Grade 0 defined as no pulmonary hemorrhage, grade 1 as needle tract hemorrhage 2 cm or less, grade 2 as hemorrhage more than 2 cm, grade 3 as lobar hemorrhage or greater, and grade 4 as hemothorax. Grade 2 or higher was considered as high grade hemorrhage. Results: Pulmonary hemorrhage occurred 97(31%) out of the 312 after lung core biopsies. Grade I hemorrhage occur after 57 (18.3%) procedures, grade II after 37 (11.8%) procedures, grade III after 2 (0.6%) procedures and grade IV occur only after one procedure (0.3%). Grade II and more hemorrhage occur after 40 (13%) procedures and were considered as high grade hemorrhage. High grade hemorrhage was statistically significant to occur more with female sex, lesions less than 3 cm, non-subpleural location and co-axial technique (P ˂0.05). Emphysema and age were not a significant risk factor for high grade hemorrhage (P >0.05). Conclusion: pulmonary hemorrhage complicating CT-guided core needle lung biopsy is common. Significant risk factors associated high grade hemorrhage includes female sex, lesions less than 3 cm, non-subpleural location and co-axial technique.
https://zumj.journals.ekb.eg/article_67831_08b74c8116e710fe683e5477217d8c4f.pdf
2020-09-01
787
794
10.21608/zumj.2020.21172.1656
Keywords: CT (computed tomography)
pulmonary
percutaneous
core biopsy
Mostafa
Assy
mostafa83assy@gmail.com
1
Department od Radiodiagnosis, Zagazig University, Zagazig, Egypt
LEAD_AUTHOR
Ahmed
Nasr
anasr1998@yahoo.com
2
Radiology Department, Chest Disease Hospital, Kuwait
AUTHOR
Mohamed
Shebl
mshebl2000@hotmail.com
3
Environmental and Occupational Medicine Department, Minoufiya University, Egypt.
AUTHOR
Haitham
Dawood
ghysoma2@gmail.com
4
Department of Radiodiagnosis, Zagazig University, Zagazig, Egypt
AUTHOR
ORIGINAL_ARTICLE
Occupational Lead Exposure among Petrol Station Workers in Sana’a City, Yemen: Awareness and Self-Reported Symptoms
Background: This study assessed the awareness of occupational lead exposure risks, self-reported lead poisoning symptoms and work practices and using personal protective equipment among petrol station workers in Sana'a city, Yemen.Subjects and methods: A cross-sectional study was conducted among 172 petrol station workers in nine districts of Sana'a between January and May 2017. Data about demographic characteristics, awareness of the lead exposure risks, self-reported lead poisoning symptoms and work practices and use of personal protective equipment were collected. Inclusion criteria were workers who gave informed consent to participate, were aged 18-60 years and had been working for ≥6 months. The data were then analyzed using appropriate statistical tests. Results: The majority of workers were aware of the adverse health effects of leaded petrol (61.0%) and that lead is an environmental pollutant (60.5%). However, personal protective equipment was poorly used. Workers with secondary education and above had better practices than those with primary education. Approximately 76.2% of workers had poor knowledge of lead risks, and 13.4% of them had good practices. The most common self-reported symptoms were neurological, including fatigue (68.0%), concentration difficulties (61.6%), joint pain (58.1%) and headache (55.2%). Conclusions: Petrol station workers in Sana’a realize the exposure to lead risks because leaded petrol is the fuel type used in the country. Although the majority of workers perceived such adverse health effects, use of personal protective equipment was poor among most of them. The level of workers’ education seems to influence their practices of using personal protective equipment.
https://zumj.journals.ekb.eg/article_80311_f3ff00fbd1575aab48c4e34f0f42a74d.pdf
2020-09-01
795
805
10.21608/zumj.2020.20291.1633
Lead
Awareness
Self- reported symptoms
Petrol station worker
Yemen
Ali
Alhaj
alhajjj20@yahoo.com
1
Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana'a, Yemen
LEAD_AUTHOR
ORIGINAL_ARTICLE
Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inborn enzymatic defect in the world. Determining the prevalence of G6PD deficiency is an essential step towards evaluating its impact on the health of a population. Therefore, this study aimed to determine the prevalence and factors associated with G6PD deficiency among newborns in Sana’a city, Yemen. Subjects and methods: This cross-sectional study included 397 newborns from eight public and private hospitals in Sana’a city in the period from January to March 2020. Data about gender and the factors possibly associated with G6PD deficiency were collected using a pre-designed questionnaire. G6PD deficiency was qualitatively detected in fresh blood using rapid diagnostic tests (RDTs). Data were analyzed using SPSS software, and differences were considered statistically significant at p-value
https://zumj.journals.ekb.eg/article_100435_ce1b73aee0d1284beecd96a2f732406f.pdf
2020-09-01
806
813
10.21608/zumj.2020.32403.1876
Newborns
G6PD deficiency
Rapid diagnostic test
Yemen
Mogahid
Nassar
mogahidnassar@yahoo.com
1
Department of Pathology, Faculty of Medicine and Health Sciences, University of Sciences and Technology, Sana’a, Yemen
AUTHOR
Ahmed
Hudna
drahmedhudna@gmail.com
2
Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sciences and Technology, Sana’a, Yemen
AUTHOR
Ali
Alhaj
alhajjj20@yahoo.com
3
Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana&#039;a, Yemen
LEAD_AUTHOR
Abdulhabib
Alqubaty
alqubaty71@gmail.com
4
Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Sciences and Technology, Sana’a, Yemen
AUTHOR
Talal
Alqahtani
alqahtani.talal@yahoo.com
5
Department of Microbiology, Faculty of Medicine and Health Sciences, University of Sciences and Technology, Sana’a, Yemen
AUTHOR