Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
SURGICAL OUTCOME OF SINGLE INCISION LAPAROSCOPIC CHOLECYSTECTOMY IN COMPARISON WITH THE 4-PORT TECHNIQUE IN ZAGAZIG UNIVERSITY HOSPITAL
1
8
EN
Abd-Elhady
Abd-Elaty
Salama
Tarek
Ezzat
Abd-Ellateif
Tarek
Abd Elazeim
Gobran
Ahmed
Abou
Hashem
10.21608/zumj.2018.12981
<br /><span class="fontstyle0">Bachground: </span><span class="fontstyle2">Cholelithiasis is one of the most common disorders of the digestive tract encountered by<br />general surgeons worldwide. Conventional or open cholecystectomy was the mainstay of treatment for a long<br />time for this disease. Laparoscopic cholecystectomy (LC) has been the gold standard for removal of the<br />gallbladder since the early 1990s. Single-incision laparoscopic surgery is becoming a more widely accepted<br />surgical approach. However, the feasibility and safety of single-incision laparoscopic cholecystectomy (SILC)<br />are yet to be established. The present study compared outcomes following the use of SILC or conventional<br />laparoscopic cholecystectomy (CLC) on patients with gallbladder disease.</span><span class="fontstyle0">Aim: </span><span class="fontstyle2">To compare the perioperative<br />results of single port laparoscopic cholecystectomy with the standard 4-port technique.</span><span class="fontstyle0">Subjects and methods:<br /></span><span class="fontstyle2">The study involved 72 symptomatic gallbladder disease patients underwent laparoscopic cholecystectomy in<br />Zagazig University hospital.36 patients underwent SILC, and 36 patients underwent CLC. Clinical and surgical<br />outcomes were compared.</span><span class="fontstyle0">Results: </span><span class="fontstyle2">The SILC and CLC groups were similar in terms of age, gender ratio, body<br />mass index, and diagnoses. The two groups were also found to be similar in terms of postoperative clinical<br />course and complications. The SILC group had a longer operation time, less postoperative pain, and a shorter<br />hospital stay with better aesthetic results than the CLC group.</span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">SILC was as safe and feasible as<br />CLC. The operating time was longer otherwise it has almost similar clinical outcomes to those of CLC.<br /></span><span class="fontstyle0">Keywords: </span><span class="fontstyle2">Four port technique, Laparoscopic surgery, Single port surgery</span><strong><br /><br /></strong>
Keywords: Four port technique,laparoscopic surgery,Single port surgery
https://zumj.journals.ekb.eg/article_12981.html
https://zumj.journals.ekb.eg/article_12981_cf4921ba3626bf1fe77866ba059f532e.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
ASESSMENT OF IMAGING IN CONGENITAL INNER EAR ANOMALIES AND ITS RELATION TO COCHLEAR IMPLANTATION
9
18
EN
Ezz El-Din
M
El Shiekh
Gamal
A
Abdel-Maksoud
Hassan
A
Wahba
Ibrahim
M
Saber
10.21608/zumj.2018.12987
<span class="fontstyle0">ABSTRACT<br />Background</span><span class="fontstyle1">: congenital SNHL may be caused by abnormalities of th-e membranous, or bony labyrinth. Because of<br />improvements in imaging techniques and appearance of high resolution CT and MRI, anomalies of bony labyrinth can<br />be diagnosed. MR imaging helps in identification of non-osseous partitioning of the malformed cochlea and<br />identification of the neural structures contained within the internal auditory canal. The cochlear implantation has<br />radically changed the outlook for profoundly deaf adults and children. </span><span class="fontstyle0">Aim of work: </span><span class="fontstyle1">to identify different types of<br />inner ear anomalies, and to detect the percentage of patients who are amenable to cochlear implantation, and<br />difficulties that occur during the operation. </span><span class="fontstyle0">Patients and methods: </span><span class="fontstyle1">This prospective study was carried out on sixty<br />patients from 2015 till 2017 in ORL Department, Zagazig University. All patients underwent thorough preoperative<br />evaluation especially by high resolution CT and MRI. These patients were classified according to type of diagnosed<br />anomaly, and CI operation were done to patients who were amenable for surgery. </span><span class="fontstyle0">Results: </span><span class="fontstyle1">The results of this study<br />show congenital inner ear anomalies distribution according to involved part and its percent in relation to total number<br />120 ears. Cochlear hypoplasia is present in 6 ears 4.5%, common cavity is present in 4 ears 3%, IP1 is present in 4 ears<br />3%, IP2 is present in 22 ears 16.7%, IP3 is present in 10 ears 7.6%, posterior rotated cochlea is present in 8 ears 6.1%,<br />dilated vestibule is present in 4 ears 3%, isolated SCC hypoplasia is present in 4 ears 3.03%, SCC hypoplasia with<br />common cavity is present in 4 ears 3.03%, dysplstic SCC is present in 9 ears 6.8%, dilated IAC is present in 6 ears<br />4.5%, hypoplastic IAC is present in 24 ears 18.2%, VCN hypoplasia is present in 24 ears 18.2%, isolated EVA is<br />present in 48 ears 36.4%. In our study all operated cases were done through facial recess approach. Operated cases were<br />51 out of 66 about 77.3%. </span><span class="fontstyle0">Conclusion: </span><span class="fontstyle1">CT and MRI are mandatory investigations for any patient prepared for cochlear<br />implantation. Preoperative diagnosis of inner ear anomalies allows exclusion of anomalies that are considered as<br />contraindication for CI operation.</span>
Keywords: Cochlear implantation,Posterior tympanotomy approach,Mastoidectomy,Major complications,Minor complications
https://zumj.journals.ekb.eg/article_12987.html
https://zumj.journals.ekb.eg/article_12987_137d72074f443ccb7aed6ac23881e06e.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
IFFERENT SURGICAL TECHNIQUES OF SKULL BASE RECONSTRUCTION: EVALUATION AND OUTCOME
19
23
EN
Hazem
S.
Soliman
Samy
H.
Mohamed
Tarek
H.
Abdel-Bary
Mohamed
Reda
Abd Elaziz
10.21608/zumj.2018.12993
<span class="fontstyle0">ABSTRACT<br /></span><span class="fontstyle0">Background </span><span class="fontstyle2">: cerebrospinal fluid (CSF) leak is the most common complication after skull base surgery. It carries<br />a high risk of life threatening complications (e.g., tension pneumocephaly, meningitis, cerebritis, and brain<br />abscess).<br /></span><span class="fontstyle0">Patients and Methods</span><span class="fontstyle2">: We present twenty patients, ages 2-55 years, eight males and twelve females with<br />different skull base pathologies operated by different surgical modalities (microscopic transcranial, endoscopic<br />endonasal and combined micro-endoscopic techniques) at neurosurgery department, faculty of medicine, Zagazig<br />University, between Jan. 2016 to Jan. 2018. Prophylactic antibiotics and anticonvulsants were rourtinely given.<br />Lumbar drain was not used.<br /></span><span class="fontstyle0">Results</span><span class="fontstyle2">: the success rate was (95%) and only one patient (5%) developed post operative CSF leak which<br />responded to conservative measures. This suggests that proper sealing of the skull base defect has been achieved.<br />There was no infection, no mortality and the long term follow up showed good functional and aesthetic results.<br /></span><span class="fontstyle0">Conclusion</span><span class="fontstyle2">: The reconstructive process although being the last step in the surgical procedure, but it's a very<br />important one. It should be planned well before surgery. Meticulous repair of the already present or resultant<br />defect should be performed in every case.</span>
Skull base defect,skull base reconstruction,cerebrospinal fluid leakage,dural reconstruction
https://zumj.journals.ekb.eg/article_12993.html
https://zumj.journals.ekb.eg/article_12993_7bf978e3c7f7f91bebed2793ec05c2e2.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
MODIFIED SELVESTER QRS SCORE REDUCTION FOR PREDICTION OF MYOCARDIAL SALVAGE FOLLOWING SUCCESSFUL REPERFUSION OF ACUTE ST ELEVATION MYOCARDIAL INFARCTION
24
33
EN
Ahmed
Shafie
Ammar
Islam
Abd El-Moneem
El-Sherbiny
Islam
ElSayed
Shehata
Cheng
-I-
Cheng
Islam Ghanem
Ahmed
Ghanem
10.21608/zumj.2018.12996
<span class="fontstyle0">ABSTRACT<br /></span>
<span class="fontstyle0">Background: </span><span class="fontstyle2">Achieving optimal angiographic coronary flow after acute ST elevation myocardial infarction<br />(STEMI) isn’t the best parameter of success. Perfusion of the microvasculature is more important. QRS score<br />plays an important role for early risk stratification for STEMI. It is a simple electrocardiographic (ECG)<br />parameter for assuring the presence or absence of microvascular obstruction.<br /></span><span class="fontstyle0">Aim of the work: </span><span class="fontstyle2">The aim of this clinical study is to validate the 90 minutes modified Selvester QRS score<br />reduction as a reliable predictor of myocardial salvage, represented by 3 months global longitudinal strain (GLS)<br />value, following successful reperfusion of acute STEMI.<br /></span><span class="fontstyle0">Material/Methods: </span><span class="fontstyle2">The study population included 400 patients presented with first acute STEMI with<br />successful reperfusion by thrombolysis (Group I- 200 patients: mean age=57.1 ± 11.6 years) or primary<br />percutaneous intervention (PPCI) (Group II- 200 patients: mean age=58.2±9.8 years). Basal and 90 minutes after<br />reperfusion electrocardiography was done with assessment of ST resolution and modified Selvester QRS score.<br />Basal and 3 months follow up echocardiography was performed with assessment of ejection fraction (EF) and<br />GLS as an indicator for myocardial salvage with its impact on long-term clinical outcome.<br /></span><span class="fontstyle0">Results: </span><span class="fontstyle2">90 minutes ST resolution and QRS score reduction were significantly higher in PPCI group (P.: 0.04*,<br />0.03*). Patients in group I had non-significant improvement of EF (P.: 0.22) during follow-up, but highly<br />significant improvement of GLS (P.: ˂0.001**) compared to the basal echocardiographic study. Patients in<br />group II had significant improvement of EF (P.: 0.01*) during follow-up, and highly significant improvement of<br />GLS (P.: ˂0.001**) compared to the basal echocardiographic study. As regarding correlation with 3 months<br />GLS value, there was highly significant negative correlation between 3months GLS and (ST resolution and QRS<br />score reduction) (P.: ˂0.001**). Receiver operating characteristics (ROC) curve analysis shows that 90 minutes<br />QRS score reduction has the best cut off value of 70% to predict 3months GLS improvement with 80%<br />sensitivity and 79% specificity.<br /></span><span class="fontstyle0">Conclusions: </span><span class="fontstyle2">Modified Selvester QRS score reduction 90 minutes after reperfusion is a cheap bedside ECG<br />parameter added to ST resolution, can be considered as a reliable predictor of future myocardial salvage with its<br />impact on long-term clinical outcome and modifying management strategies.</span>
Modified Selvester QRS score • Myocardial infarction• Myocardial salvage
https://zumj.journals.ekb.eg/article_12996.html
https://zumj.journals.ekb.eg/article_12996_cc019195724e4a67a6dd551bb5679566.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
PREDICTION OF LEFT VENTRICULAR SYSTOLIC AND DIASTOLIC FUNCTIONS SIX MONTHS FOLLOWING MITRAL VALVE REPLACEMENT USING NEW ECHO DOPPLER INDICES
34
43
EN
Moataz
Abdelmonem
Elkot
Ahmed
Shafie
Ammar
Islam
Abd-ELmoneem
ELsherbiny
Khaled
Hassan
Abdelbary
10.21608/zumj.2018.12998
<span class="fontstyle0">ABSTRACT<br /></span><span class="fontstyle0">Background: </span><span class="fontstyle2">The development of left ventricular dysfunction is a major concern in the management of patients with<br />severe mitral regurgitation. In the initial stages, contractility impairment may be ‘‘invisible’’ by the traditional methods<br />to assess the ventricular function, because of different loading conditions. This fact can mask the presence of LV<br />dysfunction. Sometimes, LV dysfunction may be ‘‘unmasked’’ only by change in loading conditions after surgical<br />correction, leading to the development of overt LV dysfunction and congestive heart failure. The identification of<br />contractile dysfunction at an early stage and surgical correction may avoid the development of irreversible postoperative<br />LV dysfunction.<br /></span><span class="fontstyle0">Objectives</span><span class="fontstyle2">: To test the efficacy of new echocardiographic indices in predicting post operative left ventricular<br />dysfunction and compare the diagnostic accuracy of these indices .<br /></span><span class="fontstyle0">Subjects and Methods: </span><span class="fontstyle2">The study included 41 patients with severe isolated Mitral regurgitation with ejection fraction<br />> 50 %, prepared for mitral valve replacement. Patients were examined clinically and by Echocardiography pre and post<br />operative. The following Echo Doppler modalities were done to the patients pre operative and 6 months post operative:<br />Global longitudinal strain(GLS) , Modified Simpson ,dp/dt , IVRT/T(E-è) the early diastolic Driving Force , early<br />diastolic and early systolic mitral annular velocity by tissue Doppler. Patients were then classified into Four sub groups<br />according to post operative systolic and diastolic function, Group 1A were patients with normal post operative systolic<br />function , Group 1B were patients with post operative systolic dysfunction , Group 2A were patients with normal post<br />operative diastolic function , Group 2B were patients with post operative diastolic dysfunction.<br /></span><span class="fontstyle0">Results</span><span class="fontstyle2">: For prediction of systolic dysfunction ROC curve analysis showed high significant value of pre operative GLS<br />in predicting post operative systolic dysfunction with cutoff value= -18.5 , high significant value of pre operative<br />modified Simpson in predicting post operative systolic dysfunction with cutoff value=54.5, and significant value of pre<br />operative dp/dt in predicting post operative systolic dysfunction with cutoff value=1166 mmHg/sec. The multivariate<br />analysis showed that the independent variables for predicting post operative systolic dysfunction were pre operative<br />GLS and dp/dt.<br />For prediction of diastolic dysfunction ROC curve analysis showed high significant value of pre operative GLS in<br />predicting post operative diastolic dysfunction with cutoff value=-18.5, and significant value of pre operative<br />IVRT/T(E-e\) in predicting post operative diastolic dysfunction with cutoff value=2.95. Multivariate analysis showed<br />that the independent variables for predicting post operative diastolic dysfunction were preoperative GLS & preoperative<br />IVRT/T (E-e\).<br /></span><span class="fontstyle0">Conclusions</span><span class="fontstyle2">: We can depend on pre operative Global Longitudinal Strain (GLS) and dp/dt in predicting post operative<br />systolic dysfunction with cut off value=-18.5 and 1166 mmHg/sec respectively. We can also depend on preoperative<br />GLS and IVRT/T (E-e\) in predicting post operative diastolic dysfunction with cutoff value=-18.5 and 2.95<br />respectively</span>
Keywords: Left Ventricular Dysfunction •Mitral Valve Replacment •Predictors
https://zumj.journals.ekb.eg/article_12998.html
https://zumj.journals.ekb.eg/article_12998_ce7afb0379b4c3ab48facdbba8a1813b.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
MICRONEEDLING AND GLYCOLIC ACID PEEL FOR TREATMENT OF ACNE SCAR; COMPARATIVE STUDY
44
54
EN
Amr
Nazir
Saadawi
Abdallah
Mohamed
Esawy
Walaa
Elsayed
Mohamed
10.21608/zumj.2018.13001
<span class="fontstyle0">ABSTRACT<br /></span><span class="fontstyle0">Background</span><span class="fontstyle1">: Atrophic acne scars are common and undesirable outcome of acne vulgaris related to<br />both its severity and delay in treatment. Such scars can be classified according to the depth and shape<br />of the collagen loss: ice pick, boxcar, or rolling. Many options are available for treatment of acne scars<br />such as: laser surgery, radiofrequency intervention, chemical peels, chemical reconstruction of skin<br />scars (cross technique), dermabrasion, needling, subcision, punch techniques, fat transplantation, and<br />other tissue augmenting agents.</span><span class="fontstyle0">Objective</span><span class="fontstyle1">: The aim of this study was to compare between GA peel<br />monotherapy and microneedling with dermapen monotherapy in treatment of acne scars. Moreover,<br />combined treatment of GA peel and microneedling with dermapen is compared to each of the above<br />monotherapies in treatment of acne scars.</span><span class="fontstyle0">Methods</span><span class="fontstyle1">: Thirty patients of both sexes (10 men and 20<br />women) with age ranged from 19-45 years old with different types of atrophic acne scars were enrolled<br />in the study. Patients were randomly divided into three groups: Group I</span><span class="fontstyle0">: </span><span class="fontstyle1">Included ten patients (4 males<br />and 6 females) aged 27 - 45 years. They had microneedling with dermapen for treatment of the scars.<br />Group II: Included ten patients (4 males and 6 females) aged 19- 42 years. They had glycolic acid 35%<br />peel for treatment of the scars. Group III: Included ten patients (2 males and 8 females) aged 19-39<br />years. They were treated with skin microneedling with dermapen combined with glycolic acid 35%<br />peel.</span><span class="fontstyle0">Results</span><span class="fontstyle1">: Results revealed that there was statistical significant decrease between acne scar grade in<br />dermapen group before and after treatment with degree of improvement (80%). Also, in glycolic acid<br />group before and after treatment with degree of improvement (70%). Statistical significant decrease<br />between acne scar grade in combination group before and after treatment with degree of improvement<br />(100%). Statistical significant increase in frequency of improvement in rolling compared to boxcar and<br />icepick in all groups and also in boxcar compared to icepick.</span><span class="fontstyle0">Conclusion</span><span class="fontstyle1">: Dermapen and glycolic acid<br />peel are effective and safe techniques in acne scars especially (superficial scars). Combination of<br />dermapen and glycolic acid peel is more effective than monotherapy by either dermapen or glycolic<br />acid peel and also helps in improvement of deep acne scars.</span>
Microneedling,Glycolic acid,acne scar
https://zumj.journals.ekb.eg/article_13001.html
https://zumj.journals.ekb.eg/article_13001_9884d73d998017efa9c88965edef098d.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
DOPAMINE RECEPTOR D3R AND D4R MRNA LEVELS IN PERIPHERAL LYMPHOCYTES IN PATIENTS WITH SCHIZOPHRENIA AND ITS CORRELATION WITH SEVERITY OF ILLNESS
55
65
EN
Asaad
A.
Shalanda
Rafek
R.
Abd Ellatif
Mohamed
G.
Negm
Amal
S.
El Shal
Heba
Ahmed
Abdelsalam
10.21608/zumj.2018.13003
<span class="fontstyle0">ABSTRACT<br />Objective: </span><span class="fontstyle2">This study aimed to assess D3R and D4R mRNA levels in patients with schizophrenia.<br /></span><span class="fontstyle0">Subjects: </span><span class="fontstyle2">Thirty six schizophrenia patients; 24 males (66.7%) and 12 females (33.3%) and 36 healthy<br />individuals; 23 males (63.9%) and 13 females (36.1%) as control subjects.<br /></span><span class="fontstyle0">Methods: </span><span class="fontstyle2">All schizophrenia patients are thoroughly screened and diagnosed for schizophrenia using<br />DSM-IV diagnostic criteria for schizophrenia.<br /></span><span class="fontstyle0">Results: </span><span class="fontstyle2">The mean values of D3 and D4 receptors mRNAs level among both studied cases and controls<br />show a highly statistically significant difference (P <0.001) between both schizophrenia patients and<br />their controls regarding levels of D3 and D4 mediators. D3 receptor mRNAs level influenced by PANS<br />scale of schizophrenic patients, as level of D3 R increased in PBLs with decreased schizophrenia<br />severity, and the difference was statistically significant (P <0.001), while the difference in D4 R level<br />was not statistically significant (P >0.05).<br /></span><span class="fontstyle0">Conclusion</span><span class="fontstyle2">: This study reveals that the molecular biologically-determined dopamine receptors (DR3<br />and DR4 mRNA) of peripheral lymphocytes are reactive after taking antipsychotics, and that increased<br />expression of dopamine receptor in peripheral lymphocyte has possible clinical significance for<br />subgrouping of schizophrenia.</span>
DR3: dopamine receptor 3,DR4: dopamine receptor 4,RT- PCR: real time polymerase chain reaction
https://zumj.journals.ekb.eg/article_13003.html
https://zumj.journals.ekb.eg/article_13003_12e93329e9c9e8e2f2e4ab8f84f8ef36.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
STUDY OF FINGERPRINTS PATTERN IN BREAST CANCER PATIENTS INSHARKIA GOVERNORATE, A CASE –CONTROL RETROSPECTIVE CLINICAL STUDY.
66
71
EN
Alaa
Ahmed
Haggag
Alaa
Mohamed
Ibrahim Khalil
Eman
Salah-eldin
Elzahed
Mohamed
Ibrahim
Abdelhamid
10.21608/zumj.2018.13006
<span class="fontstyle0">ABSTRACT<br />Background :</span><span class="fontstyle2">Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer in<br />women. In less-developed countries, it is the leading cause of cancer death in women; in developed<br />countries. Breast cancer is one of the most extensively studied cancers and its genetic basis is well<br />established.Dermatoglyphic traits are formed under genetic control early in development but may be<br />affected by environmental factors during first trimester of pregnancy. These patterns may represent the<br />genetic make up of an individual and therefore his/her predisposition to certain diseases. The finger and<br />palmar print</span><span class="fontstyle2">s </span><span class="fontstyle2">patterns have already beenstudied with respect to various genetic diseases such as the<br />Down's </span><span class="fontstyle2">g</span><span class="fontstyle2">syndrome and Klinefeltersyndrome. The fingerprints can thus represent a simple, non<br />invasive anatomical marker of breast cancer risk.<br /></span><span class="fontstyle0">Methods :</span><span class="fontstyle2">This study was applied to fifty histopathologically-confirmed breast cancer patients and their<br />fingerprints patterns were assessed. At the same time , fifty age-matched controls were selected being<br />have no self or family history of breast cancer and the observations were recorded abd data were<br />collected.<br /></span><span class="fontstyle0">Result :</span><span class="fontstyle2">It was observed that whorl pattern is the most common fingerprints pattern to be identified in<br />breast cancer cases compared to controls. Also the quantitative difference in ridge count was<br />statistically important.<br /></span><span class="fontstyle0">Conclusion </span><span class="fontstyle2">: The pattern of fingerprints may be a useful tool in the future in identifying and also<br />screening of breast cancer.</span>
breast cancer,Fingerprints,Genetics,Screening
https://zumj.journals.ekb.eg/article_13006.html
https://zumj.journals.ekb.eg/article_13006_8008119119fd763a40fff31c2ef33b58.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
SCREENING FOR B-THALASSEMIA CARRIER AMONG STUDENTS IN ASECONDARY SCHOOL IN DIARB NEGM,SHARKIA
72
79
EN
Mervat
Abdallah
Hesham
Mohammed
Refaat
Besher
Naglaa
Ali
Khalifa
10.21608/zumj.2018.13007
<span class="fontstyle0">ABSTRACT<br /></span><span class="fontstyle1">Background</span><span class="fontstyle2">:Beta-Thalassemia represents a major public health problem in Egypt. The carrier rate varies<br />between 5.5% to ≥ 9%; it is estimated that there are 1000/1.5 million per year live births born with β-<br />thalassemia. In spite of optimal treatment being available, only a few patients can afford it. Unfortunately,<br />most patients suffer from complications of blood transfusions, mainly transfusion transmitted viral infections<br />and iron overload. Prevention by carrier detection and prenatal diagnosis is needed in populations with high<br />incidence of the disease, such as Egypt.<br /></span><span class="fontstyle1">Methods:</span><span class="fontstyle2">This was a prospective cross-sectional study conducted on 614 secondary school students in Diarb<br />Negm, Sharkia Governorate. All subjects were subjected to the following: Complete blood count,Serum<br />ferritin level, Serum iron level, TIBC. Subjects with microcytic anemia were subjected to specific laboratory<br />tests: HPLC (High Performance Liquid Chromatography) which include hemoglobin A2(HbA2).<br /></span><span class="fontstyle1">Results:</span><span class="fontstyle2">Complete blood count testing of the 614 subjects in this study revealed that 55.2 % were normal and<br />44% were anemic, 5.6% had normocytic anemia and 39.2% had microcytic anemia.Subjects with microcytic<br />anemia were further subdivided into two groups according to their HbA2 level into; β-Thalassemia carrier<br />group with high level of HbA2 >3.5% and normal to high (serum iron, serum ferritin) and normal to low<br />TIBC were 8.5% and </span><span class="fontstyle0">Non</span><span class="fontstyle2">-carrier group; All with normal levels of HbA2< 3.5%, low serum iron, low serum<br />ferritin, high TIBC, were 31.6% of subjects and diagnosed as iron deficiency anemia.Carriers rate was 8.5%,<br />53.8% were males and 46.2% were females.There were increase in mean value of RBCS count, serum iron<br />and serum ferritin in carriers as compared to non-carriers, and decrease in mean value of HB, HCT, MCV,<br />MCH, MCHC find TIBC level in carriers as compared to non-carriers. There was a significant positive<br />correlation between HbA2 and HCT, RBCS count and serum ferritin, while significant negative correlation<br />between HbA2and MCV.<br /></span><span class="fontstyle1">Conclusion: </span><span class="fontstyle2">Carrier rate among 614 secondary school students in Diarb Negm,Sharkia Governorate was<br />8.5%.Hemoglobin A2 is the gold standard for B-Thalassemia carrier screening.</span>
Beta-Thalassemia,microcytic hypochromic anemia,Screening,B-Thalassemia Carrier
https://zumj.journals.ekb.eg/article_13007.html
https://zumj.journals.ekb.eg/article_13007_91e1726bcd9e792c5ce7c9e5ff201372.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
24
1
2018
01
01
PREDICTORS OF VARICEAL BLEEDING AFTER ESOPHAGEAL VARICES BAND LIGATION IN EGYPTIAN CIRRHOTIC PATIENTS
80
92
EN
Sahar
Goda
Zaghloul
Hoda
Abdelaziz
El Hady
Hussein
Mohamed
Hussein
Islam
Abdelsabour
Hassan
10.21608/zumj.2018.13009
<span class="fontstyle0">ABSTRACT<br /></span><span class="fontstyle1">Background</span><span class="fontstyle2">:</span><span class="fontstyle3">Bleeding from oesophageal varices is a severe complication of portal hypertension. Endoscopic<br />variceal ligation (EVL) is the treatment of choice for acute variceal bleeding. It is also performed for primary<br />and secondary prophylaxis of bleeding from oesophageal varices. After Endoscopic Band Ligation (EBL),<br />patients are at risk of post-interventional bleeding; the risk factors for this complication are poorly<br />evaluated</span><span class="fontstyle2">.</span><span class="fontstyle1">The aim of this work</span><span class="fontstyle3">: was to evaluate the risk factors for predicting variceal bleeding after elective<br />endoscopic variceal ligation (EVL). </span><span class="fontstyle0">Patients and Methods: </span><span class="fontstyle3">This study will be carried out in Zagazig<br />University Hospital and El-Galaa Family Military Hospital. The patients was subjected to different<br />demographic, clinical, biochemical, ultrasonographic and endoscopic findings. </span><span class="fontstyle1">Results : </span><span class="fontstyle3">The incidence of<br />bleeding after elective EVL was 6%. The results showed significant differences between the bleeders and<br />non bleeders regards the severity of liver disease measured by Child-Pugh score , the platelets count,<br />hemoglobin level, prothrombin time , the liver regards its ( size, echogenicity, irregularity of the surface,<br />presence of HFL and Portosystemic collaterals ) , the size and extension of varices. </span><span class="fontstyle1">Conclusion: </span><span class="fontstyle3">For<br />prediction of variceal bleeding after elective EVL; We can rely on many characteristics, such as age, gender,<br />liver function, severity of varices, number of rubber bands, and so forth. But as demonstrated by the<br />multivariate analysis, there were only four independent risk factors among these, namely moderate to<br />excessive ascites, PT > 18, number of rubber bands placed, size and extent of varices. These four risk factors<br />may therefore be more meaningful than the others for predicting the occurrence of bleeding following<br />elective EVL.</span>
https://zumj.journals.ekb.eg/article_13009.html
https://zumj.journals.ekb.eg/article_13009_d797dcbdc26c1d0d1dcb80e32249df74.pdf