Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
22
4
2016
07
01
CLINICOPATHOLOGIC CORRELATION OF CALRETININ EXPRESSION IN BREAST CANCER
1
9
EN
Mayada
Farrag
Amro
El-karef
Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Maha
Amin
Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Nagwa
Helal
Omar
Ali
Department of Oncology Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
10.21608/zumj.2016.4649
Introduction and aims: It was found that calretinin is expressed in many tumors other than mesothelioma including breast carcinoma. We aim to assess calretinin expression in correlation with other clinicopathological parameters of breast carcinoma.<br />Methods: By using tissue microarrays, 225 breast cancer cases were immunostained for calretinin, estrogen receptors, progesterone receptors, and HER2.<br />Results: Tumors of high grade showed high calretinin expression (P<.0001). High loco-regional recurrence was also associated with high expression of calretinin (P=.005). Negative ER showed significant association with high calretinin expression (P= .005). Negative PR, positive Her2neu showed also high significant association with high calretinin expression (P< .001).<br />Conclusion: Calretinin expression is high in high grade hormone negative tumors
Calretinin,Breast carcinoma
https://zumj.journals.ekb.eg/article_4649.html
https://zumj.journals.ekb.eg/article_4649_e9ee0c183184e033d5f5a0a65a613350.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
22
4
2016
07
01
FEMALE URINARY INCONTINENCE: SPECTRUM OF FINDINGS AT PELVIC MRI AND URODYNAMICS
1
9
EN
El-Sayed
Zidan
Radiology Departments,Faculty of Medicine, Zagazig University.
Mohamed
Amin
Radiology Departments,Faculty of Medicine, Zagazig University.
Esam
Hemat
Ibrahim
Samaha
Surgical Urology Departments,Faculty of Medicine, Zagazig University.
10.21608/zumj.2016.4650
Background: Weakening of the female pelvic floor is a commondebilitating disorder. It leads to abnormal descent of the urinary bladder, the uterovaginal vault and the rectum, resulting in urinary incontinence, fecal incontinence and pelvic organ prolapse.<br />Objective: is to focus on the role of urodynamic pelvic MRI for cases with stress urinary incontinence.<br />Patients and Methods: This study was carried out from Feb 2015 to April 2016 at radiology department of Zagazig University hospitals. It included 30 female patients; with stress incontinence and 10 volunteer normal females. The mean age 59 ± 12.4 yrs (ranged from 25 to 78 yrs). They were referred from the outpatient clinics of Zagazig University hospitals to radiology department for urodynamic pelvic MRI examination. Results: Regarding the stress urinary incontinence, MRI parameters has marked agreement (P: 0.00) with urodynamic studies.<br />Conclusion: The use of urodynamic pelvic MRI has a promising results in assessment of stress incontinence of urine. It is free from any radiation hazards. MRI has larger field of view making it suitable for accurately estimating larger degrees of proplase.
Pelvic MRI,stress incontinence,urodynamic,Pelvic organ Prolapse
https://zumj.journals.ekb.eg/article_4650.html
https://zumj.journals.ekb.eg/article_4650_fc72f93e9a62fb483659fce9ea6cebc2.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
22
4
2016
07
01
THE ROLE OF SECOND TRIMESTER UTERINE ARTERY DOPPLER ULTRASOUND,INHIBIN-A AND PLACENTAL GROWTH FACTOR IN PREDICTION OF PREECLAMPSIA.
1
11
EN
Walid
AbdelgalilElsheikh
Department of Obstetrics and Gynecology, Faculty of medicine, Alazhar University, Cairo, Egypt
Mohammad
Behery
The international Islamic Center for Population Studies and Researches, Alazhar University, Cairo, Egypt
Elsayed
Farag
Department of Obstetrics and Gynecology, Faculty of medicine, Alazhar University, Cairo, Egypt.
Farid
Hassan
Department of Obstetrics and Gynecology, Faculty of medicine, Alazhar University, Cairo, Egypt.
Fawzy
Abdelaziz
Department of Obstetrics and Gynecology, Faculty of medicine, Alazhar University, Cairo, Egypt.
Mohammad
Alkholy
Department of Obstetrics and Gynecology, Faculty of medicine, Alazhar University, Cairo, Egypt.
10.21608/zumj.2016.4651
Objective: to evaluate the role of second trimester uterine artery Doppler ultrasound velocimetry (UADV), maternal serum Inhibin-A andplacental growth factor (PLGF) concentrations and as predictors of preeclampsia.<br />Study design: Cohort study.<br />Methodology: This prospective study was conducted at Obstetrics & Gynecology department, Alazhar University hospitals, Cairo, Egypt between May 2012 and May 2014. Ninety low risk normotensive singleton pregnant women were recruited for the study. Blood samples were collected at 16- 18 weeks, centrifuged to extract the serum then stored at – 80 °C until tested for inhibin-A and free PLGF levels. At 22-24 weeks, bilateral uterine artery Doppler velocimetry were recorded. The primary outcome was preeclampsia defined as hypertension with proteinuria after 20 weeks gestation. Women who developed preeclampsia were compared against normotensive control group.Statistical analysis: Receiver operating characteristics (ROC) curves were used for detection of the sensitivity and specificity and cut off value for each predictor using SPSS version 21 for analysis (IBM Inc., Chicago, Illinois, USA).<br />Results:Eight cases out of 90 had developed preeclampsia. Women who developed preeclampsia had significantly higher median uterine artery resistance index (UARI) (0.645 ± 0.3 vs. 0.485 ± 0.16, P = 0.009) and significantly lower median uterine artery pulsitility index (UAPI) (0.625 ± 0.24 vs. 1.0 ± 0.68 with P= 0.001) than normotensive control group.Maternal serum inhibin-A level was significantly higher in women with preeclampsia than the normotensive control group (1375 ± 1431 vs. 540 ± 1900 with P = 0.016) while level of PLGF was non-significantly lower in women with preeclampsia than the normotensive control group (275.5 ± 369 vs. 390 ± 583 with P = 0.156). ROC curves were analysed for cases and control groups, areas under the curve (AUC) was 0.709 (95% CI, 0.527– 0.891, P = 0.016) for UARI with sensitivity of 87.5%, specificity 74% at cut off value ≥ 0.5650, AUC was 0.848 (95% CI, 0.742– 0.955, P = 0.001) for UAPI with sensitivity of 80%, specificity 74% at cut off value ≤ 0.735, AUC was 0.758 (95% CI, 0.566 - 0.951, P = 0.016) for Inhibin-A with a sensitivity of 75%, specificity of 80% at cut off value of ≥ 832.5 pg/ml and finally AUC was 0.652 (95% CI, 0.447 – 0.858 and P = 0.165) for PLGF with a sensitivity of 74% and specificity of 50% at cut off value of ≤ 205 pg/ml.<br />Conclusion: second-trimester uterine artery Doppler indices, serum Inhibin-A and PLGF and may be helpful as a predicting markers for preeclampsia.
Inhibin-A,placental growth factor,Doppler indices,uterine artery,preeclampsia
https://zumj.journals.ekb.eg/article_4651.html
https://zumj.journals.ekb.eg/article_4651_e0ef815f3a8fd279aa3a12c467bf4310.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
22
4
2016
07
01
POSTPRANDIAL EXERCISE IS SUPERIOR TO REGULAR CONTINUOUS EXERCISE IN HBA1C REDUCTION FOR TYPE 2 DIABETICS IN SAUDI ARABIA
1
10
EN
Nezar
Alba
Assistant Professor, MBBS,ABIM,FRCP,ABIM-Endocrinology Consultant Endocrinologist and Thyroidologist
hayer
Tunsi
Internship UmAl-Qura University[
10.21608/zumj.2016.4652
BACKGROUND AND OBJECTIVES: Exercise helps people on diet to lose weight, also helps having better Blood Pressure. The aim of the study is to compare the response of glycosylated hemoglobin (HbA1c), body mass index (BMI) and incidence of hypoglycemia to continue running exercise (group A) and intermittent postprandial exercise (group B) for individuals with type 2 diabetes in Jeddah – Saudi Arabia<br />DESIGN AND SETTINGS: Out of 44 enrolled patients from Jeddah region, 24 patients were group A, who were asked to run daily for 45 minutes at any time of the day, continuous running without stopping -as much as they can, and 20 other patients were group B, who were asked to run 60-90 minutes after main meals for 15 minutes three times daily. The study involves mandatory baseline visit then follow up, once after 12 weeks.<br />Results: The mean age was 42.1 (2.8) [Mean (SD)] years for group A, whereas it was 43.8 (1.7) years for group B. 17% were males and 83% were females for group A whereas all patients were females for group B. The main BMI was 26.2 (1.2) kg/m2 (group A), while it was 26.9 (1.0) kg/m2 (group B).<br />The mean Postprandial Blood Glucose (PPG) was 150.4 (7.5) mg/dl (group A), while it was 144.5 (11.2) mg/dl (group B). There was no statistically significant difference in the mean PPG between group A and group B (P > 0.05).<br />50 % were house wives (group A), whereas 100% were house wives (group B). There was statistically significant difference in patients’ jobs for group A compared to group B (P < 0.05 and > 0.01)<br />All patients on metformin and statin for both groups, and There was no statistically significant difference in Current Medication between group A and group B (P > 0.05), but There was statistically significant difference in the mean dose between group A and group B (P < 0.05 and > 0.01).The mean time of exercise was 33.6 (14.1) min/day (group A), while it was 33.5 (8.3) min/day (group B). There was no statistically significant difference in time of exercise groups between group A and group B (P > 0.05).<br />Both groups resulted in a decline in HbA1c. However, the mean of HbA1c was dropped from 8 % (at baseline visit) to 7% (at the end of the study. There was a very high statistically significant decrease of 1% (P < 0.001) and percent change was -12.5%.for group A, whereas the mean of HbA1c was dropped from 7.9% (at baseline visit) to 6.4% (at end of the study)..There was a very high statistically significant decrease of 1.5% (P < 0.001) and percent change was -19.1%for group B.<br />There was a very high statistically significant difference in HbA1c reduction from baseline visit to end of the study between group A and group B (P < 0.001).<br />At follow up visit after 12 weeks, 12(50%) of group A were controlled (HbA1c < 7%), while 18 (90) % of group B were controlled (HbA1c < 7%). There was high statistically significant difference in controlled patients (HbA1c < 7%) between group A and group B (P < 0.01 and > 0.001).<br />Group A resulted in a decline in mean of BMI which was the percentage decrease in BMI was 1.7% with group A. There was statistically significant decrease in mean BMI from baseline visit to the end of the study for group A of 0.4 kg/m² (p < 0.05 and > 0.01), while there was no statistically significant difference for group B (P > 0.05).<br />There was high statistically significant difference in BMI reduction from baseline visit to the end of the study between group A and group B (P < 0.01 and > 0.001).<br />The mean number of episodes of hypoglycemia was 1.8 (3.7) times (group A), while it was 3.9 (3.8) times (group B). There was no statistically significant difference in number of episodes of hypoglycemia in group A compared to group B (P > 0.05).<br />Conclusion: The reduction of HbA1c levels with continuous running exercise is less than its levels with intermittent postprandial exercise during both exercises in individuals with type 2diabetes, while the reduction of BMI levels with intermittent postprandial exercise is less than its levels with continuous running exercise However, No significant change in incidences of hypoglycemia was found in both groups.
exercise,Type 2 Diabetes,HbA1c,BMI and Hypoglycemia
https://zumj.journals.ekb.eg/article_4652.html
https://zumj.journals.ekb.eg/article_4652_d93c3dd189a05da14b8b2bea18a16807.pdf
Zagazig University, Faculty of Medicine
Zagazig University Medical Journal
1110-1431
2357-0717
22
4
2016
07
01
COMPARISON OF ENDOSCOPIC FINDINGS WITH GERD SYMPTOMS SCORE IN ZAGAZIG UNIVERSITY HOSPITALS, EGYPT.
1
8
EN
Waleed
Ismail
Internal Medicine Department, Zagazig University, Egypt
Ashraf
Khalifa
Internal Medicine Department, Zagazig University, Egypt
10.21608/zumj.2016.4653
Background: Gastroesophageal reflux disease (GERD) may need repeated endoscopy for diagnosis and follow up, this may concern psychological and financial burden on patient. Aim of the work:The aim of our work was to evaluate the benefit of the FSSG as a useful and a practical tool for diagnosing of GERD patients compared to the endoscopic results. This was mainly to avoid repeated uses of endoscopy for diagnosis and may reduce the medical costs and save the patients time Patients & Methods: This study was carried out at Zagazig University, Faculty of Medicine, Internal Medicine Department, Gastroenterology and endoscopy unit during the period from June 2015 to December 2015.The subjects were 131 Egyptian patients aged ≥18 year (mean 46.3± 16.8 year; male/female ratio 1.8/1) who presented with symptoms of heartburn, regurgitation and epigastric pain or discomfort. They were scheduled for esophagogastroduodenoscopy. It was done after approval of Local Ethics Committee and patient’s consent was obtained. Pre-endoscopy Procedure: Our study depends on a simplified questionnaire for evaluation of the symptoms of GERD called FSSG (Frequency Scale for Symptoms of GERD) which consists of 12 questions; all must be answered by all subjects Endoscopy Procedure: All subjects underwent esophagogastroduodenoscopy. The results of endoscopy were classified and graded according to Los Angeles classification into GERD A, B and C according to the severity of the endoscopic findings. After that the final endoscopic diagnosis was compared to the predicted diagnosis resulting from the Regression model and Equation. Results: Based on the endoscopic findings, the number of patients with GERD Los Angeles Class A, B and C was 18.3, 15.3 and 6.9 % respectively. Clinical obesity patients were 3 distributed as duodenal ulcer (DU) = 2 and GERD B = 1 patient. Overweight patients were 58 distributed as gastric ulcer (GU) = 13, DU = 7, functional dyspepsia (NUD) = 14, GERD A = 8, GERD B = 8 and GERD C = 8 patients. Normal weight patients were 63 distributed as GU = 14, DU = 11, NUD = 11, GERD A = 16, GERD B = 10 and GERD C = 1 patients. Underweight patients were 7 distributed as DU = 1, GU = 2, NUD = 3, GERD A = 0, GERD B = 1 and GERD C = 0 patients. Usage of the FSSG questionnaire with Regression Model help us to predict strongly GERD A by 95.8%, also GERD B by 95% and weakly predict DU by 81.8%, GERD C by 77.7%, GU by 60.7% and NUD by 50%.Conclusion: Noninvasive assessment tool FSSG questionnaire was useful for objective evaluation of symptoms in GERD patients and avoid repeated endoscopic examination which is undesirable in terms of medical costs and the burden on the patient and save our developing country efforts and resources.
missed
https://zumj.journals.ekb.eg/article_4653.html
https://zumj.journals.ekb.eg/article_4653_8fa65c5eefba0583b55f07a9845f8e56.pdf