2024-03-29T14:26:14Z
https://zumj.journals.ekb.eg/?_action=export&rf=summon&issue=20083
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Assessment of right ventricular function in patient with chronic renal failure on regular dialysis by echocardiography
walied
abd elshafey
magdey
Abd-Elsamei
Nader
Kandeel
Mohamad
Soliman
Background:In recent years, the assessment of right ventricular function by tissue Doppler imaging (TDI) has been established as a common approach to detect preclinical abnormalities of cardiac function and has also been proposed as a reliable predictor of prognosis.Patient and Methods :We studied 114 patients with end stage renal failure on regular hemodialysis through permanent brachial arterio venous fistula (AVF). and divide them into two groups(case and control group) were compared regarding to clinical and echocardiographic data. Results:No statistically significant differences were found among the groups regarding age and gender, there was statistical significance difference between the two groups in all risk factors (P < 0.01) except for Smoking there was no significant statistical difference, Among HD RV dimensions were significantly larger (Basal level – Mid level – Longitudinal length) compared to control group (P < 0.01) ).Doppler Tie index was significantly higher in HD patients with mean value of (0.56±0.12) when compared to control group (0.36±0.032) with (P value < 0.001), denoting significantly more depressed RV function in HD patients.Conclusions:Myocardial Performance index (tie index) and S wave measured by tissue Doppler are simple and quick parameters that can used in HD patients to asses global right ventricular function with good accuracy.Both parameters not affected by right ventricular geometry and have the advantage of simultaneously recording both systolic and diastolic velocity patterns .Key words:Right ventricular function , Hemodialysis ,echocardiography
right ventricular function
Hemodialysis
Echocardiography
2021
01
01
1
8
https://zumj.journals.ekb.eg/article_38331_a6109b928a49349dae7892a70cd5f889.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
TOLL LIKE RECEPTOR TYPE FOUR GENE POLYMORPHISM IN NEONATAL SEPSIS IN ZAGAZIG UNIVERSITY CHILDREN’S HOSPITAL
shrouk
nafea
Mamdouh
Gaafar
Ahmed
Fakhr
Wessam
Mokhtar
Introduction: The immune response constitutes the first-line defense against microbial infections. Toll like receptors (TLRs) play a fundamental role in neonatal innate immunity, and one of them, toll like receptor 4 (TLR4) is considered a major pattern recognition receptor (PRR) in recognizing lipopolysaccharide (LPS) of gram-negative bacteria. Single nucleotide polymorphisms (SNPs) among various TLR genes have been identified and maybe related to susceptibility/resistance to certain infections and other inflammatory diseases.Objective: The purpose of this study was to find a relation between sepsis-related outcomes in neonates and TLR4 Asp299Gly gene polymorphism.Method: we carried out a case control study on 72 neonates. 36 neonates with culture proven gram-negative sepsis and 36 neonates as controls. Both groups were genotyped for TLR4 Asp299Gly gene polymorphism, by polymerase chain reaction (PCR), and restriction fragment length polymorphism analysis (RFLP) by using BccI enzyme.Results: No statistically significant association between TLR4 Asp299Gly gene polymorphism and severity of neonatal sepsis (P>.99).Conclusion: TLR4 Asp299Gly gene polymorphism is not associated with increased severity of gram-negative bacterial sepsis in neonates.
Key words: Gram-negative sepsis
TLR4 Asp299Gly polymorphism
Genotyping
neonatal intensive care unit (NICU)
2021
01
01
9
19
https://zumj.journals.ekb.eg/article_41420_f3510e4c3dac9b85aa014329527d2682.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Significance of Postprandial Triglycerides in Coronary Artery Disease
Husam
Zigheel
mohammed
aboleineen
tamer
mustafa
alaa
salama
Background: Coronary artery disease (CAD) is the most common cause of mortality worldwide and determination of contributing factors is essential. Studies have demonstrated the association of severe anatomical coronary artery disease (CAD) with postprandial triglycerides (TG) concentrations. Nevertheless the relationship between less severe atherosclerosis plaque burden and postprandial TG is less established. Objective: The study was aimed to study the significance of postprandial triglyceride as predictor for the severity of coronary artery disease. Patients and methods: The current study included one hundred and five individuals presented to Cardiology Department, Zagazig University Hospitals, within a time period of six months from July 2018 to December 2018, Inclusion criteria includes CAD based on coronary angiography. Results: In our study, ischemic heart disease is statistically higher in patients with abnormal CA and abnormal postprandial TG versus patients of abnormal CA with normal PP TG (51.9% versus 28.6%) respectively. Conclusions: According to our results, we concluded that a high level of postprandial TG would be a more reliable test than fasting TG in predicting the severity of CHD.
Atherosclerosis
Triglycerides, Coronary artery disease (CAD), Postprandial triglyceride, Fasting triglyceride
2021
01
01
20
28
https://zumj.journals.ekb.eg/article_45225_6e19882522dd3c40f753ccddee59be9b.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Relationship between blood pressure indices and severity of coronary atherosclerosis
Salwa
Ghoniem
hanan
radwan
hisham
naas
Introduction: Blood pressure assessment is important for the evaluation of cardio-vascular disease and can be measured both invasively and noninvasively. Conventional noninvasive brachial blood pressure measurement has its own limitations. Objective: To assess the relation between blood pressure indices and atherosclerotic burden in patients with obstructive coronary artery disease. Methods: A Cross sectional study was conducted at Cardiology Department of the Zagazig University Hospitals during the period from April 2018 to October 2018, This study included 90 consecutive stable patients with evidence of obstructive CAD as detected by elective coronary angiography. Patients were divided into 2 groups due to SYNTAX scores. Group I : >22 SYNTAX score, Group II :
blood pressure
coronary atherosclerosis
Fractional Diastolic Pressure
Blood Pressure indices
2021
01
01
29
37
https://zumj.journals.ekb.eg/article_47695_927d4a98e7f522eef17c6b9f69d9a49f.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Pulmonary Function Tests in children suffering from Inflammatory Bowel Diseases in Zagazig University Hospital
Hend
Abd-Elhamid
Hatem
Hussien
Hossam
Elsaadany
Background: Extra intestinal manifestations of inflammatory bowel disease (IBD) are a systemic illness that may affect up to half of all patients. Among the extra intestinal manifestations of IBD, those involving respiratory system are relatively rare. However, there is a wide variation of such manifestations, spanning from airway disease to lung parenchymal disease, pleural disease, enteric pulmonary fistulas and pulmonary function test abnormalities. This study aimed to detect the abnormalities of pulmonary function tests in inflammatory bowel diseases in children Method: A prospective Cross sectional study was carried out at Gastro entrology unit and pulmonary unit pediatric department, in Zagazig University hospitals during the period from December 2016 to January 2018. Twenty patients with inflammatory bowel disease were recruited in the study and full history and clinical examination was taken .full lab was drawan such as CBC,ESR ,CRP,LFT and KFT. pulmonary function tests (PFTs) was performed with spirometer. Statistical analysis was done for these data. Results: PFT was abnormal in 40% patients. abnormal PFT was classifed into restrictive 6 (30%), and obstructive defects 2 (10%) .IBD patients with active disease have abnormal pulmonary function tests .No relation of PFT abnormalities was found with age, sex, duration of disease, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat IBD. Conclusion: the study proved that IBD patients with active disease have abnormal pulmonary functions with predominant involvement of restrictive. Active IBD was more often associated with abnormal PFT than the disease in remission.
inflammatory bowel disease
extra intestinal manifestation
abnormal PFT
2021
01
01
38
47
https://zumj.journals.ekb.eg/article_58705_645fad58ec302d0df0180a6f11bd0def.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
The Efficacy Of Intralesional Steroid Injection in The Treatment Of Corrosive Esophageal Strictures in Children
Nadia
Ismail
Saad
Mansour
Hatem
Hussien
ABSTRACTBackground: In the treatment of serious corrosive esophageal strictures, esophageal dilatation may be inadequate. The purpose of this study was to evaluate the effectiveness of intralesional steroid injection as an adjunct to dilatation therapy. Methods: This is a clinical trial study, which was conducted on 42 patients with corrosive esophageal stricture. The patients were admitted to pediatric endoscopic department at Zagazig University Hospitals. They were randomly divided into 2 groups. Group I/ control included 21 patients (10 males and 11 females; mean age 28±20.8 months), they received dilatation therapy only and Group II/ study included 21 patients (13 males and 8 females; mean age 40.4± 20.5 months), they received an additional treatment by 1ml intralesional steroid injection of triamcinolone actenoid in the strict part. Results: Number of dilatation therapy, dysphagia and vomiting were highly statistically significantly decreased in study group vs control group. At the end of the follow-up period, 30% of control group improved while 85% of the study group improved. Conclusions: The findings of the current study support the use of intralesional triamcinolone in corrosive esoghageal stricture as an adjuvant treatment to dilatation therapy, as it improved the outcome in the studied cases.
Key Words: intralesional steroid injection
corrosive esophagealstricture
caustic stricture
esophageal dilatation
2021
01
01
48
57
https://zumj.journals.ekb.eg/article_85002_e6ea71ffe5303b4aca8d7b31ac401aef.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
The Effect of Renal Dysfunction on Circulating Sclerostin Level in Patients with Type 2 Diabetes
Mahmoud
El sebaie
mohamed
arafat
mohamed
fawzy
ibrahim
salem
Background and aim:Sclerostin, a soluble canonical Wingless integration site signaling inhibitor, is formed by osteocytes and is vital for bone physiology. This work aimed to appraise the role of sclerostin level in early detection of renal osteodystrophy in patients with type 2 diabetes mellitus (T2DM).Method:This cross sectional study was done on 75 diabetic patients with different stages of chronic kidney disease (CKD) in the Internal Medicine department, Zagazig University hospital.The patients are classified into 3 groups according to glomerular filtration rate(GFR),group 1(stage 1,2 CKD),group 2(stage 3 CKD),group 3(stage 4,5 CKD). The patients underwent history taking, examination and laboratory studies including routine investigations and assessment of serum sclerostin. Results: The mean age of the patients was 51.07 ± 4.40 years. Males represented 61.3% of them. Mean Sclerostin of them was 5.42 ± 4.53 ng/ml. There are significant differences between groups with different CKD stages regarding sclerostin, hemoglobin, serum creatinine, blood urea, eGFR, phosphorus and parathyroid hormone. There is significant positive correlation between serum sclerostin and all of serum creatinine, blood urea, phosphorus and parathyroid hormone. There is significant negative correlation between it and eGFR. On multivariate regression analysis, it was found that age, serum creatinine, blood urea, eGFR and albumin/creatinine ratio (ACR) significantly associated with serum level.Conclusion: Sclerostin level is negatively correlated with eGFR in diabetic patients with impaired renal function. Serum sclerostin levels increase in diabetic patients starting from CKD-G3 stage. Age, serum creatinine, blood urea, eGFR and albumin/creatinine ratio (ACR) significantly associated with its level.
Chronic Kidney Disease
diabetes
sclerostin
2021
01
01
58
69
https://zumj.journals.ekb.eg/article_67709_44c2fa22ca6bf593f9b65ad690ca6d51.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Outcome of Decompensated Hepatitis C Virus Cirrhotic Patients Treated with Direct Acting Antiviral Drugs
Amir
Ahmed
Sahar
Zagloul
Hoda
El-hady
Ahmed
Gomaa
AbstractBackground: All oral direct-acting antivirals (DAAs) effectively treat chronic hepatitis C infection (HCV) and widely used for patients with compensated cirrhosis. However, data regarding their safety and efficacy in patients with decompensated cirrhosis are insufficient .Aim: to test efficacy, safety and outcome of DAAs in the treatment of decompensated HCV related cirrhotic patients (CTP-B). Patients and Methods:prospective study among 62 chronic HCV cirrhotic patients, divided into two groups. Group I(the study group) included 32 patients with CTP-B treated for 12 weeks by sofosbuvir (SOF) 400 mg once daily plus Daclatasvir (DCV) 60 mg once daily plus Ribavirin (RBV) with initial dose 600 mg /day), while group II (the control group) included 30 patients with CTP-A treated by (SOF 400 mg once daily + DCV 60 mg once daily +RBV dosed according to body weight) for 12 weeks. According to the National Committee for control of viral hepatitis (NCCVH). Follow up after end of treatment (EOT) for 24weeks so the total period of the study 36 weeksResults: cases achieved SVR in Group I: 93.75% and in group II:100%, Liver parameters were improved from baseline to 24 weeks after end of treatment. The most common adverse effects were anemia, no patients died by the end of the study, but one case 3.1% in group I stopped treatment due to severe complications.Conclusion:Treatment with DAAs in patients with CTP-B is effective and safe, but patients remain at risk of life-threatening complications as HCC and liver-related morbidity.
HCV
Sofosbuvir
Ribavirin
SVR
DAA
2021
01
01
70
80
https://zumj.journals.ekb.eg/article_69648_31a01feef0e11f80fc5170f0a2ebd5d2.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Frequency and Risk Factors of Minimal Hepatic Encephalopathy Among Patients with Compensated Cirrhosis
Abdallah
Eid
Mahmoud
Sharafeddin
Esam
Zurkany
marawan
nabil
Background: Minimal hepatic encephalopathy (MHE) is characterized by a mild neurocognitive impairment encompassing neuropsychological and neurophysiological alterations not detectable by clinical examination. This study aims at assessing the frequency and risk factors for developing minimal hepatic encephalopathy in patients with compensated cirrhosis. Methods: This cross sectional study was conducted on 60 patients with compensated cirrhosis in Elzagazig University Hospital and Elmatarya Teaching Hospital from December 2017 to June 2018, diagnosis of minimal hepatic encephalopathy was established using by mini mental status examination test and psychometric studies, they underwent full history, laboratory investigations and abdominal Doppler ultrasonography by professional radiologist assessing the presence of any Porto systemic shunts and measuring serum ammonia level. Results: About 37% had MHE. Female represented 65% with mean age 49.82 years. There is statistically significant relation between MHE and smoking, comorbid diabetes, hypertension, high ammonia level and portosystemic shunt. Smoking, being single, illiterate, portosystemic shunt, comorbid diabetes and hypertension increased risk of MHE by 4.57, 3.05, 2.31, 25.94, 3.29 and 3.55 folds. Male gender and normal ammonia level were protective factors. There is significant relation between MHE and all of age, platelet count, serum albumin, ammonia and INR. Older patients, low platelet count and serum albumin, high ammonia level and INR were detected among patients with MHE. Increasing ammonia level was significant independent risk factor for MHE (AOR= 4.06) Conclusions: MHE is a prevalent condition among patients with compensated cirrhosis with high ammonia level and portosystemic shunts as a strong risk factors for its development.
hepatic encephalopathy
shunt
ammonia
2021
01
01
81
88
https://zumj.journals.ekb.eg/article_76281_5d5a186e77d0a379287b8970cc0d9a19.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR AMONG MANIC AND EUTHYMIC PATIENTS WITH BIPOLAR DISORDER TYPE I .
Mohamed
Reda Abd Ellatif
Abd El Shafi
Khashba
Fatima
Sherif
Amira
Youssef
nermin
raafat
Background: Bipolar disorders (BD) have been accompanied with disturbances in neuroplasticity. Brain-derived neurotrophic factor (BDNF) plays important role in neuroplasticity. It plays a vital role in the neurobiology of such disorders.Objectives: This study aimed to check BDNF serum levels in euthymic BD type I patients and correlate them with the clinical manifestations.Methods: Forty-eight Egyptian individuals were included in this study. They were arranged in three groups: The first one ‘G-A’ included twelve patients diagnosed with bipolar I disorder in manic episode; while the second ‘G-B’ consisted of twelve patients diagnosed with bipolar I disorder in full remission, and the third group ‘G-C’ consisted of 24 healthy persons as control subjects. The cases were diagnosed according to DSM-5 and psychometric analysis. The BDNF levels were assessed using the technique of quantitative sandwich enzyme immunoassay.Results: There was no statistical significant difference between the studied groups as regard demographic characteristics. Serum BDNF levels were lower in bipolar I patients in manic episode compared with those in euthymic state and also control subjects.Conclusion: patients with manic episode of bipolar I disorder have lower serum BDNF levels compared with those with euthymic state and control group.
Brain-derived neurotrophic factor
Bipolar Disorder
manic episode
euthymia
2021
01
01
89
96
https://zumj.journals.ekb.eg/article_43553_ec4ef6f72aaea6069bbe30fb6359c5b4.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Effect of vitamin D supplementation and muscular exercise on irisin serum level and related metabolic parameters in type II diabetic albino rats
Nermeen
Zaitoun
Ahmed
Bahaa Eldin
Akmal
Diab
Mai
Hasan
Background and purpose: Irisin is a newly discovered myokine that reduces obesity and improves insulin resistance via the browning of white adipose tissues resulting in increased thermogenesis that promotes insulin sensitivity. The aim of this work was to detect the effect of Vitamin D and exercise on irisin expression in type II diabetic albino rats.Objective: The aim was to detect the effect of supplementation with Vitamin D and the role of exercise in improving type II diabetes, investigating their effects on irisn level.Design: This study was carried out on Fifty adult male albino rats which were divided into two main groups: Group I "control" in which the animals were fed on normal laboratory chow diet without exercise training. The remaining forty rats were used to establish type II diabetes, group IIA (n=10 rats) as diabetic control, group IIB (n=10 rats) exercised by swimming for 6 weeks, group IIC (n=10 rats) received vitamin D and group IID (n=10 rats) exercised and received vitamin D. Results: The results showed that exercise and vitamin D supplementation improved serum level of irisin, HOMA-IR and lipid profile (Cholesterol, LDL and triglycerides) in diabetic rats and the best effect was found with vitamin D administration in conjunction with exercise training Conclusion: Combined exercise training and vitamin D administration improved serum irisin level and lipid profile in diabetic albino rats that was reflected on insulin resistance
Irisin
HOMA-IR
exercise
vitamin D and diabetes
2021
01
01
97
103
https://zumj.journals.ekb.eg/article_42515_3a89ce4c47d3d9c9754546b0d82df8c2.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Impact of biologics drugs adherence on treatment outcomes and work productivity of Al Sharqia Governorate patients with Ankylosing Spondylitis
manal
youssef
dina
el rafey
Aim & objectives: to improve ankylosing spondylitis (AS) treatment outcomes by clarifying the impact of biological medication adherence on their treatment outcomes, quality of life, and work productivity. Patients and methods: Sixty -six patients with AS were included according to eligibility criteria recruited from the Rheumatology and Rehabilitation Department at Zagazig University Hospitals(ZUH) and insurance hospital. Patients characteristics are collected. Biologics medication adherence was evaluated by the Compliance Questionnaire on Rheumatology (CQR). Disease activity and treatment response outcome measures were recorded at baseline of biologics, after 6 months,s and after one year. Results: Insurance, education, employment, and early diagnosis are the modifiable factors which can increase adherence to biologics drugs in adherent cases ASDAS CRP, ASDAS ESR, and BASADI were significantly decreased after 6 months and highly significantly decreased after 12 months. BASFI & BASMI were significantly decreasing after 12 months, frequency of overall work and activity impairment was decreased after 6 months but after 12 months the decrease became significant with percent of the reduction in both more than 50%. Also AS quality of life (ASQOL), significantly decreased after 6 months and 12 months. In non -adherent there was a significant increase in ASQOL score after 12 months Conclusion: Biological therapy adherence leads to control of disease activity confirmed by the percentage of change in activity parameters after 6 months and highly significant change after 12 months of follow up especially BASMI in addition to improvements of work productivity and activity impairment and overall health-related quality of life.
Keywords: Ankylosing Spondylitis
biologic drugs adherence
Treatment outcomes
Work productivity
2021
01
01
104
114
https://zumj.journals.ekb.eg/article_127052_34c21ed9511e2feb30059b7c83a0561d.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
TNFα -308 and +489 polymorphisms in psoriatic arthritis patients at zagazig university hospitals.
Amany
Abo-el soud
Sally
Shalaby
mohamed
hammad
Enas
Abdelhady
Background: Psoriasis is a multifactorial disease with wide range of clinical manifestations. Musculoskeletal manifestations of psoriasis include a combination of axial disease, peripheral arthritis, enthesitis and dactylitis. The tumor necrosis factor α (TNFα) gene is proposed as a fundamental gene in psoriatic arthritis (PsA). Aim of the work is to detect frequency of TNF α gene -308 and +489 polymorphisms genotypes among psoriatic and PsA patients and assess risk for psoriasis and PsA. Subjects and methods: A case control study was conducted in Rheumatology and Rehabilitation Department, Zagazig University Hospitals on 96 subjects. They were divided into three equal groups (PsA, cutaneous only psoriasis (PsC) and control). Full history taking, clinical examination and assessment of PsA activity by composite psoriatic disease activity index (CPDAI) were done. Laboratory investigations included CBC, ESR, CRP, RF, kidney and liver function tests. Detection of TNFα gene -308 and +489 polymorphisms was performed using PCR RFLP (restriction fragment length polymorphism) technique. Results: Regarding TNF (+489) genotyping, AA and GA genotypes and A allele were more frequent in PsA and PsC patients than in controls. The A allele increased the risk for PsA and psoriasis by 8.4 and 5.9 folds respectively. TNF (+489) GA genotype was associated with higher activity of PsA. Regarding TNF (-308), there was no significant difference in genotypes frequency among three groups and no relation with PsA disease activity.Conclusions: TNF (+489) A allele carried risk for PsA and psoriasis and TNF (+489) GA genotype was associated with higher activity of PsA.
Psoriasis
Psoriatic arthritis
TNF polymorphism
PCR RFLP
2021
01
01
115
121
https://zumj.journals.ekb.eg/article_41418_95aed2afe48c57799aa45885077b53f8.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Association Of Vitamin D Receptor, Interleukin7 Receptor Alpha Gene Polymorphisms With The Risk Of Multiple Sclerosis
Ansam
Zayed
Amaal
Shehata
Tarek
Gouda
Hanim
Abd elnour
AbstractBackground: Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease with unknown definite etiology. Many factors have taken part in explanation of MS pathology including genetics and environmental factors. Objectives: in this study we investigated the frequency of vitamin D receptor (VDR) gene (bsm1 and taq1) and interleukin 7 receptor alpha (IL7RA) gene single nucleotide polymorphisms (SNPs) and their association with the risk of MS. Methods: a case control study was performed on two groups. MS group with 63 MS patients diagnosed according to McDonald criteria for MS diagnosis and the control group of 63 apparently healthy individuals not having MS. Blood was collected and DNA was extracted using G-spin™ Total DNA Extraction Mini Kit provided by iNtRON Biotechnology, Korea. DNA was amplified using Polymerase chain reaction. Then analysis for VDR SNPs (bsm1 and taq1) by restriction fragment length polymorphism assay. Amplification refractory mutation system technique was carried out to evaluate IL7RA SNP. Results: we found that there was statistically significant difference in Bsm1 genotyping between case and control groups (p=0.02). As for IL7RA genotype frequency between MS patients and controls there was statistically significant difference (p=0.004). And lastly Taq1genotyping revealed no statistically significant association with MS (p=0.5). Conclusion: we conclude that VDR (Bsm1) and IL7RA SNPs are related to MS pathogenesis while VDR (Taq1) SNP is not a risk factor for MS.
Multiple sclerosis
Vitamin D receptor
Interleukin 7 Receptor
Gene polymorphism
2021
01
01
122
131
https://zumj.journals.ekb.eg/article_38536_ae6763ac21e80a62ff5fda7ec92f571b.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Vitamin D Deficiency Among Type 2 Diabetic Patients in Najran Area, Saudi Arabia.
Omar
Mohamed
Amar
Elhussein
Walid
Babikr
Mariam
AlSayed
Background: Recently there are various non-skeletal diseases associated with vitamin D deficiency such as type 2 diabetes mellitus (T2DM). The main target of this study is to investigate whether there is any relationship between serum Vitamin D levels and glycemic control in type 2 diabetic patients.Methodology: The study was carried out in Najran University Hospital, this study involved 275 type 2 diabetic patients and 136 healthy control. Fasting blood glucose (FBG), HbA1c and 25(OH) vitamin D were analyzed.Results: The results showed (8%) of diabetic patients presented with severe Vitamin D deficiency, (27. 6%) presented with moderate deficiency, (19.6%) presented with insufficiency and (44.7%) presented with sufficient levels. HbA1c % and FBG were negatively correlated with Vitamin D levels. The mean levels of vitamin D showed a highly significant difference p > 0.001 between diabetic patients (27.84 ± 14.847 ng/ml) and healthy control subjects (53.99 ± 11.401 ng/ml), Also results showed a highly significant difference p > 0.001 in vitamin D level between controlled and uncontrolled diabetic patients the level of vitamin D was (46.4 ± 17.5; 28.2 ± 14.9) respectively.Conclusions: The findings suggested that there was a high incidence of vitamin D deficiency in type 2 diabetic patients and there was an inverse relationship between Vitamin D and FBG and HbA1c.
Type II diabetes
25 hydroxycholecalciferol
HbA1c
2021
01
01
132
139
https://zumj.journals.ekb.eg/article_86564_d3db9241d77ccb69f9c01ef9b9f9c9f7.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
cystatin C serum level and radiological findings in acute ischemic stroke
adham
ismaeil
Sawsan
yousef
ahmed
badawy
rania
helal
Abstract:Background: Cerebrovascular stroke is a costly disease. Cystatin C is an important biomarker for acute ischemic stroke due to the background of accumulating evidence indicating a link between vascular disease of the kidney and brain. Aim: We investigated the association of serum cystatin C levels with radiological findings of first ever acute ischemic stroke.Patients and methods: We included in this prospective cohort study 58 adult patients with first ever acute cerebrovascular ischemic stroke of not more than 72 hours duration with normal kidney functions (26 males and 32 females with age ranged from 33 to 90 years). Serum cystatin C level was measured by enzyme-linked immune-sorbent assay ( ELISA) . All patients were subjected to brain computed tomography (CT) scan to confirm the diagnosis of acute ischemic stroke and it was repeated after 48 hours. Results: We found statistically significant positive correlation between cystatin C serum level and early signs of middle cerebral artery (MCA) infarction and size of infarction. Conclusion: There is positive correlation between serum cystatin C level and size of infarction in acute ischemic stroke.
Cystatin C
stroke
Infarct size
2021
01
01
140
147
https://zumj.journals.ekb.eg/article_43061_8555512072c907639a57adcb52620d7e.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
The efficacy and safety of Intralesional Candida Injection in Treatment of Common Warts.
Mai
Abd El Azeem
Amani
Nassar
AlShimaa
Ibrahim
Background: Warts are a common sight in dermatology and they constitute the commonest cutaneous manifestation of human papilloma virus (HPV) infection. A variety of modalities has been used and treatment may be invasive and/or conservative. Therefore, the aim of this study was to evaluate the efficacy and safety of intralesional Candida antigen injection in the treatment of common warts.Material and Methods: At outpatient dermatology clinic, 28 patients with common warts of the hands and feet were treated with intralesional Candida antigen. Side effects as well as improvements in texture after each session and after the final treatment were documented. The patients treated by 0.1 intralesional candidal injection once weekly maximum for 5 sessions for 5 weeks or less if complete recovery occur.Results: Patient’s response to treatment was assessed clinically and we found the efficacy of Candida antigen in the treatment of common wart by 35.7%. In our study, all reported side effects were mild, tolerable, and transient and did not necessitate stoppage of treatment in any of the studied patients. No recurrence during 6 months follow up .Conclusion: Intralesional Candida injection is an effective and safe modality for the treatment of common warts.Keywords: Warts, Candida injections, Immunotherapy.
Warts
Candida injections
Immunotherapy
2021
01
01
148
154
https://zumj.journals.ekb.eg/article_52217_ff0993a412420598458889e4d6014eaa.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Assesment of diabetic foot Risk factor among patients with diabetes attending to zagazig university hospital.
Ghada
Aboelezz
Rasha
Bahaa El Din
Doaa
Refaat
Background: Diabetes mellitus is a public and progressively more important chronic disease worldwide. Diabetic foot disease is one of the diabetes complications which most serious and costly. Aim: Improvement of quality of life for diabetic patients and decreasing the rate of lower limb amputation. Objectives: To examin foot status clinically and to identify foot risk category of patients with diabetes. Patients and Methods: A cross sectional study was done on 266 diabetic patients at diabetic and vascular clinics in Zagazig university hospitals.The study was done by filling a questionnaire about socio-demographic data, clinical local foot examination for all diabetic patients. Results: The largest percentage of the studied patients were males(62.8%), aged less than 60 years old (62.4%), had education up to level of basic and secondary school education (72.9%), non-workers(28.6%), married(83.1%), with moderate-income (48.9%) and were current smokers(71.1%).On clinical examination of those patients, the largest percentage had abnormal skin(58.6%), absent sweating(54.9%), present fungal foot infection (53.4%), absent sensation has done by10g monofilament test, pinprick test(60.9%)and amputation (15.4%) and most of them had a very high risk of diabetic foot disease. Conclusions: Most of the patients were categorized had a high risk of diabetic foot(68%).It was significantly associated with low education status, prolonged disease duration, insulin treatment, smoking, presence of callus, fungal infections. So we need foot care education for diabetic patients for a high quality of life and improve their awareness of foot care and self-management.
Foot care
Diabetic foot
diabetic foot disease
2021
01
01
155
165
https://zumj.journals.ekb.eg/article_44855_317c0ccada72a6e5e6e6cee46d427772.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Can Mean Platelet Volume, Platelet /Lymphocyte ratio and Neutrophil /Lymphocyte ratio predict severity of Coronary Artery calcification assessed by Multidetector CT Coronary Angiography?
Elshaimaa
Seaoud
Nada
Selim
Islam
Esherbiny
Ahmed
Mostafa
1-AbstractBackground and aim: Increasing attention is being paid to the role of inflammatory markers and their relationship to the severity of coronary artery disease. Our aim was to prove that a 3 simple CBC indices (platelet / lymphocyte ratio (PLR) , neutrophil / lymphocyte ratio (NLR) and mean platelet volume (MPV)) can help assess severity of coronary artery calcium using multi detector CT (MDCT).Methods: 70 male patients prospectively undergoing CT coronary angiography (CTCA) for chest pain or multiple risk factors for coronary artery disease (CAD) have been registered. Blood samples for complete blood count, differential leucocyte count and full lipid profile were collected.Results: There was a significant negative correlation between NLR ratio and coronary artery calcium score (CACs) (P-value
Mean platelet volume
Platelet/lymphocyte ratio
Neutrophil/lymphocyte ratio
Coronary Artery Disease
Multi detector computed tomography angiography
2021
01
01
165
173
https://zumj.journals.ekb.eg/article_120329_926494533c82cab960c9d155ab86b0ff.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Outcome of Acute Respiratory Distress Syndrome Patients Mechanically Ventilated with Low Flow Rate,Decelerating Pattern and Positive End Expiratory Pressure
Mustafa
Negm
Amany
Morsy
Adel
Ahmed
Acute Respiratory Distress Syndrome(ARDS) was recognized as the most severe form of acute lung injury, a form of diffuse alveolar injury. The current ARDS protocol does not specify any particular ventilator mode.We aimed to assess the outcome of ARDS patients in relation to low tidal volume,low inspiratory flow rate with decelerating pattern and average Positive End Expiraory Pressure(PEEP) .Patients and Methods: Twenty four newly admitted patients with ARDS were studied. Data parameters at onset of diagnosis were measured, upon them ARDS protocol of mechanical ventilation has been conducted.They were admitted in the period of November 2017 to December 2018 at Respiratory and General Intensive Care Units of Zagazig University Hospitals.Low tidal volume with permissive hypercapnea, of 8 mL/kg of predicted body weight was applied then justified by 7 ml/kg then 6ml/kg to achieve best oxygenation.Plateau pressures not exceeding 30 cm H2O was maintained.Recruitment maneuvers with PEEP of 5cm H2O with titration by 2cm H2O aiming to achieve best PEEP which reach O2 saturation≤90% without cardiac output deterioration.Lowest flow rate with decelerating pattern was applied to increase inspiratory time with subsequent improvement oxygenation. Serial recording of ventilator and ABGs parameters at 1,4,8th day of mechanical ventilation.Results:In spite of using ARDS network ventilatory protocol ,the mortality is still high (58.3%) .Trauma was the most frequent risk factor in 60% of survived patients followed by pneumonia in 20% of survived patients ,aspiration in 10% and drug overdose in10%of survived patients.Trauma was the most frequent risk factor in 28.56%
ARDS
tidal volume
PEEP
inspiratory flow rate
2021
01
01
174
183
https://zumj.journals.ekb.eg/article_46322_8daebfbb8fcae75578beb9d346e31ea6.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2021
27
1
Diagnostic accuracy of magnetic resonance imaging in pregnancies with placenta previa for assessment of abnormal placentation
Mona
Refaat
Ahmed
Salem
Mostafa
Assy
Abdelrazik
Abdelrazik
Objectives: To evaluate the accuracy of magnetic resonance imaging in assessment and characterization of placental implantation disorders in pregnant females with placenta previa. Methods: This research was carried out during period from July 2017 to June 2019 incorporated 90 pregnant females with placenta previa. The findings of MR imaging in abnormal placentation were compared with post-operative information and our results from statistical analysis were proportionated to those from the literature. Results: Out of 90 pregnant women with placenta previa, 21 cases had abnormal placentation at MRI and post-operatively, 8 cases with placenta accreta, 3 with increta and 10 with percreta. MRI has 100 % sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Conclusion: MRI was highly accurate in recognition of myometrial invasion and type of anomalous placentation with high sensitivity in diagnosis of abnormal placentation, proper assessment in pre-operative diagnosis of placental invasion and thus reducing morbidity rate and improving outcome.
Magnetic Resonance Imaging
placenta accreta
Placenta Previa
Placentation
2021
01
01
184
192
https://zumj.journals.ekb.eg/article_82638_f8be20033a5fb800968436dd30584a65.pdf