2024-03-29T01:52:42Z
https://zumj.journals.ekb.eg/?_action=export&rf=summon&issue=27455
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
ASSESSMENT OF LIVER STIFFNESS IN NONALCOHOLIC FATTY LIVER DISEASE
Introduction and aim: Several liver fibrosis markers which have been previously evaluated for the patients with viral hepatitis particularly HCV-infected patients. The combination of liver stiffness measurement by transient elastography (TE) and fibrosis scores like APRI, FIB -4 and NAFLD fibrosis score (NFS) are able to accurately diagnose or exclude the presence of severe liver fibrosis and they also reducing the number of needed diagnostic liver biopsies. The purpose of the present study was to assess liver stiffness severity in NAFLD patients by TE, and also to test diagnostic accuracy of FIB-4, NFS and APRI as simple noninvasive markers of liver stiffness in those patients. Method: This study included, 153 individuals who were divided into three groups according to fibrosis grade measured by TE, group I consisted of 62 subjects 32 were males (51.6%) and 30 females (48.4%), their mean age ± SD (44.29 ± 9.65 y), Whereas the group II consisted of 57 subjects, 22 males (38.6%) and 35 females (61.4%), their mean age ± SD (44.70 ± 9.12 y), As regard group III, it consists of 34 subjects, 13 males (38.2%) and 21 females (61.8%), their mean age ± SD (45.82 ± 9.65 y). Full history taking, thorough clinical examination and routine laboratory investigations together with different noninvasive fibrosis score and LSM was analyzed in three groups. Results: There was statistically significant difference between the three groups as regard FIB-4 and NF scores, while there was no statistically significant difference between the three groups as regard APRI. By post hoc analysis the most significant difference was between group I and III as well as group II and III. There was statistically significant positive correlation between fibrosis stage by TE and FIB4 score, glycated hemoglobin (HBA1c) and NF score. Conclusion; LSM by TE is easy, accurate way to anticipate advanced fibrosis together with other simple noninvasive measures like NFS and FIB-4 may lower the threshold for liver biopsies in NAFLD patients.
Liver Stiffness
Nonalcoholic fatty liver disease
Transient elastography
non invasive scoring systems
2018
12
01
1
10
https://zumj.journals.ekb.eg/article_192411_2f5ac728eda3246e6b079b48f19ed640.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Significance of TROP-2 and P63 Expression in Diagnosis of Papillary Thyroid Lesions: An immunohistopathological Study
Background: Thyroid cancer is the most common endocrine malignancy, accounting for 2.1% of all cases of cancer worldwide. About 77% of these cases occurring in women[1]. Approximately 90% of all thyroid cancers are differentiated; meaning that they arise from thyroid follicular cells[2]. Papillary thyroid carcinoma (PTC) is the most common histopathological type of thyroid cancer[3]. TROP-2 is a trophoblastic transmembrane glycoprotein, also known as tumour-associated calcium signal transducer 2 (TACSTD2) that signals cells for self-renewal, proliferation, invasion, and survival. It gives the cell stem cell-like qualities[4].P63 is a transcription factor belonging to the p53 family and shares structural and sequence homology with p53.Different studies support the hypothesis that p63 can function as a tumour suppressor, especially TAp63 isoform[5].
The aim: This study was conducted to evaluate the significance of TROP-2- and p63 expression in differentiation malignant from benign papillary thyroid lesions in thyroid histopathological biopsy specimens.
Methods: Forty two cases (21 cases of papillary hyperplasia associated lesions included (7 cases nontoxic colloid goiter, 7 cases toxic colloid goiter and 7 cases follicular adenoma) and 21 of papillary thyroid carcinoma(classic variant) were examined immunohistochemically using antibodies against TROP-2 and p63.
Results: TROP-2 expression was observed in 90.5 % of cases of papillary thyroid carcinoma, while none of papillary hyperplasia associated lesions cases showed TROP-2 positivity.P63 expression was observed in 19.1% of cases of PTC, while none of papillary hyperplasia associated lesions cases showed p63 positivity. There is a statistically significant difference in TROP-2 expression between PTC and papillary hyperplasia associated lesions (P<0.001). There is no statistically significant difference in p63 expression between PTC and papillary hyperplasia associated lesions (p=0.11).
Conclusion:TROP-2 was overexpressed in 90.5% of cases of PTC classic variant with specificity 100% and sensitivity 90.5% . Our results suggest that TROP-2may be considered as a useful marker in diagnosis of papillary thyroid carcinoma(classic variant). P63 was expressed in 19.1% of PTC cases with specificity 100%% and sensitivity 19%, this result suggests that p63 is less effective in diagnosis of PTC, TROP-2 and p63together can be used as diagnostic markers for papillary thyroid carcinoma.
TROP-2
P63
Papillary thyroid carcinoma
papillary hyperplasia
Immunohistochemistry
2018
12
01
11
20
https://zumj.journals.ekb.eg/article_192413_c832c43c8b1b89d4ea828b682de2df31.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Uropathogens Among Diabetic Patients At Zagazig University Hospital’s Outpatient Clinics: Prevalence And Their Antibiotic Susceptibility Patterns
Walid
Attiah
Neveen
EL-Antouny
Rehab
El-Sokkary
Mohamed
Hamed
Background: The incidence of diabetes mellitus is increasing worldwide; it has some major effects on the genitourinary system, which makes diabetic patients more liable to urinary tract infection. Despite, all these problems, antibiotics are prescribed empirically which may adversely affect antibiotic resistance so far. Therefore, the aim of this study was to identify the etiologic agents of UTI and their antibiotic susceptibility pattern among diabetic patients attending diabetic clinic of Zagazig University Hospitals. Material and Methods: A cross-sectional study was conducted in a total of 195 diabetic patients who suffered change from June 2017 to June 2018. Demographic and clinical data were collected. Clean catch mid-stream urine samples were collected and processed for identification of uropathogen. Results: E. coli was the commonest isolated uropathogen followed by Klebsiella pneumoniae. All the isolated bacteria were resistant to ceftriaxone but sensitive to ciprofloxacin. Gram-negative isolates demonstrated high level of sensitive to amikacin in 188 (96.4%) patients, imipenem and meropenem in 5 (2.6%) and ceftazidime in 187 (95.9%) patients. Gram-positive bacteria showed sensitive to amoxicillin-clavulanate, linezolid and vancomycin in 7 (3.6%) patients. Multidrug resistance was observed in about 30% of the isolated uropathogens. Conclusion: Pathogens are mostly resistant to antibiotics including ceftriaxzone and ampicillin with few exceptions including nitrofurantoin and sulfamethoxazole-trimethoprim.
Urinary tract infection
Diabetes mellitus
Antibiotic resistance
Bacteriuria
2018
12
01
21
29
https://zumj.journals.ekb.eg/article_192414_1f856e27f3d4367e64db6734d87a3a57.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Medical Education: Historical Backward, Current Trends and Challenges
The evolution of medical education started since ancient times. It depended on a master-student relationship. The master was a perfect expert concerned with learning and interested to his trainers and followers. In the early 1900s Abraham Flexner, an American higher education expert, suggested that medical schools must be linked to universities, should have a based curriculum and strong educational programs including fluently basic medical sciences and all stages of medical education should be given in classes, laboratories and hospitals. WHO recommended integration of topics in medical education to overcome the redundancy of knowledge and to enhance student ability on problem-solving, clinical skills, and critical thinking and deal more with preventive medicine and health of the society. Problem-based learning (PBL) is a common method in medical schools around the world. Many educators suggested that a PBL curriculum had to be strengthened by a limited number of well-chosen lectures. Unfortunately traditional lectures are still the most popular instructional method in the universities. Educational innovation and reform new methods of integrated teaching challenged teachers to change how they plan curriculum and make clinical teaching relevant to the lessons taught using these newer methods. The balance of clinical and basic medical sciences and their integration in a manner that best serves the medical student are sure to be the focus of expected innovations in medical education.
Problem-Based Learning
integrated curricula
education
2018
12
01
30
40
https://zumj.journals.ekb.eg/article_192416_8b63e9ac0e40d4f2d5953cd9b0103de3.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Effect of Experimentally Induced Hypothyroidism on Structure of Adult Albino Rats’ Testes and Possible Protective Role of L-carnitine
Background: Hypothyroidism is a metabolic disorder affecting the functions of many tissues in the body including the testis. It acts via creating an oxidative stress and decreasing the antioxidant capabilities. Testis is rich in the polyunsaturated fatty acids content and lacks strong intrinsic antioxidant system making it prone to such oxidativde stress. L-carnitine (LC) regulates long chain fatty acids metabolism; and is considered a valuable antioxidant factor. Aim: To evaluate the effect of hypothyroidism induced by propylthiouracil (PTU) on rat’s testes with the possible protective role of LC. Methods: Forty-eight adult male albino rats have been used in this work. The animals were divided into three groups with sixteen animals in each. Group 1 (Control): Animals were kept without medications. Group 2 (PTU-treated): was subjected to administration of PTU; while group 3 (PTU and LC) received both PTU and LC. By the end of the experiment “30 days”, blood samples were taken for hormonal essay then animals were anaesthetized and sacrificed. Specimens were homogenized for biochemical analysis; epididymal content of each rat was obtained immediately for semen analysis. Testes’ specimens were harvested, prepared and examined by light microscope examination. Results: Induced hypothyroidism was noticed to cause histopathological, morphometric and biochemical changes in rat’s testes. LC protected the testicular specimens against such changes; it also improved the seminal quality and quantity as well as testicular structure and biochemistry. Conclusion: Hypothyroidism could result in hazards to the structure of testis. Fortunately co-administration of LC is suggested to reduce such hazards.
adult rats
testes
hypothyroidism
L-carnitine
Oxidative Stress
Microanatomy
2018
12
01
41
55
https://zumj.journals.ekb.eg/article_192417_20df84b1955083c573d3ddf49d6de282.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
NEUROPROTECTIVE EFFECT OF ADIOL AGAINST LITHIUM PILOCARPINE INDUCED-SEIZURES, BEHAVIRAL CHANGES AND COGNITIVE DEFICITESIN MALE MICE
Background: ADIOL (5-androsten-3β, 17β-diol) is a metabolite of dehydroepinadro-sterone (DHEA) with antioxidant, anti-inflammatory and antiapoptotic effects. Objectives: examine the possible neuroprotective effect of ADIOL against lithium pilocarpine (li-pilo) induced-seizures, behavioral changes and cognitive deficits Methods: 120male mice were divided into six groups, each contain 20 mice which subdivided equally to A for behavioral tests and B for biochemical tests. "Vehicle Group I", "Control Group II "li-pilo", Valproate (VPA) group IІІ (17 mg/kg,i.p). "ADIOL group IV" ADIOL 0.5 mg/kg, "ADIOL group V" ADIOL 1.5 mg/kg "ADIOL group VI" ADIOL 3.5 mg/kg. The animals were observed for the occurrence of spontaneous recurrent seizures (SRS). Open field test, dark light box, acceleration rotarod test and T maze spontaneous alternation were performed. Six mice from each group were euthanized 30 days after pilo injection. Their brains were removed for assessment of oxidant/antioxidant status, anti-inflammatory and antiapoptotic parameters Results: li-pilo produced seizures associated with behavioral changes and cognitive deficits, significant decrease in brain superoxide dismutase (SOD) activity and significant elevation in the brain malondialdehyde (MDA), interleukin1β (IL-1β), nuclear factor-kappa B (NF-КB) and caspase-3 (cap-3) in relation to vehicle group. VPA suppressed seizures concomitant with improvement of behavioral changes but worsen short term memory, significant increase in brain SOD activity and significant decrease in MDA, IL-1β, NF-КB and cap-3 levels in relation to li-pilo model. ADIOL ( 0.5 to 1.5 and 3.5 mg/kg) produced dose dependent decrease in seizures associated with significant improvement of behavioral changes and cognitive deficits, significant increase in brain SOD activity and significant decrease in MDA, IL-1β, NF-КB and cap-3 levels in relation to li-pilo model. Conclusion: ADIOL protects against li-pilo induced seizures, behavioral changes and cognitive deficits due to antioxidant, anti-inflammatory, antiapoptotic effects.
ADIOL
lithium pilocarpine
Seizures
Valproate
2018
12
01
56
70
https://zumj.journals.ekb.eg/article_192418_3459d9e6d59192f1be77411deae9d394.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Sero-prevalence of Hepatitis C Virus Antibody among Type 2 Diabetic Patients Attending the Outpatient Clinic of Internal Medicine Department at Zagazig University Hospitals: Across-sectional descriptive study
ABSTRACT
Background: Diabetes Mellitus (DM) and viral hepatitis C virus (HCV) are two major health problems of economic and social burden in Egypt. HCV is highly prevalent in type2 diabetic patients (T2DM patients) as it interferes with the insulin-signaling pathway. Also T2DM is one of extra-hepatic manifestations of HCV. Major known modes of transmission for HCV include injectable drug use, dental procedures, barberin g, tattooing, body piercing and sharing contaminated materials. Aim and objective: To evaluate the sero-prevalence of HCV antibodies among T2DM patients at the outpatient clinic of Internal Medicine Department at Zagazig University Hospitals aiming to determine the magnitude of HCVab among these patients. Patients and methods: This study is a cross-sectional descriptive study conducted on T2DM patients. Each patient filled three questionnaires: the first about socio-demographic data, the second includes patient history of T2DM and assessment of knowledge about the disease and the third one for assessment of knowledge, prevalence and risk factors of HCV. Blood samples were obtained from all patients for testing HCVab. Results: The prevalence of HCVab among T2DM participants is 31.3%. The prevalence is statistically higher in type2 diabetic males with the age range between 27 – 85 years old, diagnosed as T2DM for more than 10 years, had a family history of HCV and had risk factors for HCV transmission. Conclusion:The high prevalence of HCVab in T2DM patients (31.3%) may be because the majority of participants were of low socioeconomic level, had positive familyhistory for HCV and were subjected to risk factors for HCV transmission.
Diabetes mellitus
hepatitis C
type2 diabetic patients
2018
12
01
71
78
https://zumj.journals.ekb.eg/article_192419_879f2a67bfb1a2e2ef809d465fdb0199.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
STEM CELL THERAPY IN COMMUNICATION DISORDERS
Background: Stem cell therapy is considered as a golden type of therapy that can help us in the future to solve many problems that we suffer from them. We can use stem cell in treating many communication disorders as in autism and in vocal fold regeneration after atrophy and scar.
Subjects and methods: We collected studies done on using stem cell in autism and vocal fold regeneration in the last 15 years in from 1-2002 until 3-2017 in Pub-med and e-medicine
Results: We extracted the information from the studies and the results were discussed to know stem cell effectiveness and safety.
Conclusion: Stem cell therapy is effective in treating many symptoms of autism and improve histology and morphology of vocal fold after atrophy and scar of vocal fold also, stem cell therapy is safe.
stem cell- therapy
role
treatment-autism-vocal fold regeneration
2018
12
01
79
92
https://zumj.journals.ekb.eg/article_192420_a1e41fa1526fe6fd61d421b07ba39c30.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Between Hope and Risks; Insight on Delayed Sternal Closure Technique Outcomes in Adult Patients underwent Cardiac Operations
Background: the delay of sternal closure after cardiac operations may offer the chance for survival in critical conditions; mainly sever hemodynamic instability and uncontrollable bleeding. Many concerns about hope of survival and possible risks especially mediastinitis or wound infection still represent dilemma for surgeons in such situations. The aim of our study is to evaluate the outcomes of delayed sternal closure technique after cardiac operations.Methods:this prospective study included 28 adult patients. Differentpreoperative, operative patient’s data were collected and postoperative outcomes were recorded.Results: survival rate was 61% of patients; average time till sternal closure was 1.0±2.6 days. Main causes of death were multi-organ failure (n=4), low cardiac output (n=4), sepsis (n=3).Superficial sternotomy wound infection occurred in 3patients (10.7%) while only one patient developed deep sternotomy wound infection.Conclusions : delayed sternal closure is a beneficial technique that may carry the hope of survival for highly critical patients , risk of mediastinitis or wound infection were low and should not make the surgeon hesitate to offer the patient this valuable chance for survival when needed.
sternal
mediastinitis
hemodynamics
Bleeding
2018
12
01
93
99
https://zumj.journals.ekb.eg/article_192421_a0f18822454fd08e37f63e0e91481477.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
The relationship between elevated HbA1c% and surgical site infection in patients undergoing CABG
Objective: Controversy still exists whether adequacy ofpreoperative diabetes control measured by HbA1c% is a predictor of elevated incidence of surgical site infection (SSI) after CABG.
Methods:prospective study was done on 48 diabetic patients underwent CABG surgery. They were classified into 2 groups, Group (A):24 patients with fair glycemic control (HbA1c isunder or equal to 7%), Group (B): 24 patients with poor glycemic control (HbA1c above 7%). SSI either sternotomy or saphenous wound infection were studied in both groups.
Results: Superficial wound infection for group A was 12.5% and 25% for group B with significant statistical differenceamong the two groups. Deep Sternal Wound Infection (DSWI) was (4.1%) group A and group B with no statistical significance.As regard Saphenous wound infection was (8.3%) for groupA and (25%) for group B with statistical difference, also group B has higher frequency of hospital re-admission and need inotropes more than groupA.
Conclusions: Elevated HbA1c >7 in patients undergoing CABG associated with increasedfrequency of SWI and saphenous harvesting site infection but there was no significant increase in DSWI.Patients with elevated HbA1c >7 has more resistant peri-operative control of RBS. Finally we found that good peri-operative control of RBS associated with decreased rate of SSI after CABG. HbA1c is simple test that may offer the surgeon with better risk profile assessment and give additional prognostic data when discussing morbidity and mortality risks with patients and their relatives.
HbA1c
Glycosylated Hemoglobin
Outcome
Coronary artery bypass grafting
Surgical Site Infection
2018
12
01
100
107
https://zumj.journals.ekb.eg/article_192423_afd77277512c27f2ed28909771782463.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Penetrating Keratoplasty Versus Deep Anterior Lamellar Keratoplasty In Management Of Keratoconus In Zagazig University Hospitals .
Mohammed
Abdul Kadir
Hossam
Mohammed
Mohammed
Mostafa
Sameh
Fouda
Aim : To evaluate the visual , refractive , topographic outcomes and potential complications of penetrating keratoplasty versus deep anterior lamellar keratoplasty in treatment of keratoconus cases.
Patients and Methods : In this prospective interventional comparative clinical study, 40 eyes of patients with keratoconus needing keratoplasty either DALK or PKP were enrolled . The primary outcome measure after both groups was the BSCVA 12 months postoperatively .The secondary outcome measures included UCVA , mean spherical equivalent, mean manifest refractive cylinder ,mean keratometric readings, mean topographic astigmatism ,endothelial cell count and endothelial cell loss .
Results : 40 eyes of 35 patients with keratoconus were enrolled : 20 eyes had undergone DALK , and 20 eyes had undergone PKP . The follow up period for both groups was 12 months. Both study groups demonstrated a comparable outcome in terms of the BSCVA: 0.545±0.095 and 0.55±0.095 (P =0.868),UCVA: 0.335±0.093 and 0.306±0.112(P = 0.379),mean manifest refractive cylinder : -3.08±0.494 and -3.35±1.339 (P = 0.394) , mean K: 45.26±1.473D and 45.07±1.755D (P = 0.713)and topographic astigmatism: 3.725±1.017 and 4.095±1.466 (P = 0.359) in DALK and PKP respectively . However, the postoperative endothelial cell density in DALK (2768.6±213.101) differs significantly from it in PKP (2375.65±192.25) (P <0.001) and the percentage of endothelial cell loss was statistically significant higher in PKP 14.206±2.278 compared to DALK 1.533±0.792 (P<0.001). Also, there was a statistically significant difference in mean spherical equivalent between both groups with myopic shift in DALK group -4.663±0.915 and-3.413±2.049 P =0.013. The endothelial graft rejection rate in PKP was 15 % while in DALK it was 0 %.
Conclusion: Deep anterior lamellar keratoplasty is an effective and safe alternative surgical technique to the standard penetrating keratoplasty in treatment of keratoconus.
Penetrating keratoplasty
deep anterior lamellar keratoplasty
big bubble and Keratoconus
2018
12
01
108
117
https://zumj.journals.ekb.eg/article_252775_dcdcd5d826bab23a876b27323c6ccf83.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Prognostic Significance of Beclin 1 Expression in Diffuse Large B Cell Lymphoma Patients Receiving Immuno-chemotherapy at Zagazig University and Health Insurance Hospitals
Fouad
Abu-Taleb
Haitham
Elsheikh
Ahmed
Embaby
Emam
Ismael
Iman
Farahat
Shereen
Elshorbagy
Background: Diffuse large B-cell lymphoma (DLBCL); the commonest subtype of NHL, is genetically, biologically and clinically heterogeneous disorder which is potentially curable with combination chemo-immunotherapy, however, Prognostic assessment is important for tailoring therapy. Beclin-1, a mammalian ortholog of the yeast autophagy-related gene 6 protein, and important mediator of autophagy was found to predict clinical outcomes in many cancer patients.
Methods: This prospective cohort study was carried out at medical oncology department, Zagazig University and Health insurance hospitals and included 32 patients with CD20 positive de novo DLBCL, they were subjected to routine clinical and laboratory assessment with immunohistochemical analysis for beclin-1 status which further divided the patients into 2 groups of high and low beclin-1,Patients received first line therapy with R-CHOP regimen, then assessed for therapy response and followed up after treatment for estimating overall (OS) and disease free survival (DFS).
Results: High Beclin-1 expression was found in 12 patients (37.5%) and it wasn’t associated with significant correlation with clinic-demographic patient characteristics. The Complete remission rate was 59.4% and beclin-1 expression didn’t significantly affect clinical outcome, except for the significant death rate (p= 0.02). The 3-year OS and DFS were 78.1% and 45.0% respectively and high beclin-1 was significantly associated with better OS (by multivariate analysis) but not DFS.
Conclusions: Beclin-1 didn’t provide a prognostic indicator for response to treatment. However, it's found to be independent predictor for OS in DLBCL patients.
DLBCL
prognostic
autophagy
Beclin-1
2018
12
01
118
127
https://zumj.journals.ekb.eg/article_252790_6cc7c9184da378717bb867f8ca76a5bd.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
DAY 3 VERSUS DAY 5 EMBRYO TRANSFER A PROSPECTIVE RANDOMIZED STUDY
Mai
Zaitoun
Abdulmagid
Sarhan
Ahmed
Ismail
Sherin
Shazly
Ahmed
Abdou
ABSTRACT
Background: Transfer of embryos at the blastocyst stage has been associated with exceptionally high implantation rates. There are, however, only a prospective randomized studies comparing day 3 versus day 5 embryo transfers. Furthermore, the number of embryos replaced in the day 3 group transfer is often higher than the number of blastocysts replaced, thereby affecting implantation rates-Subjects & Methods: A total of 86 patients undergoing standard Intracytoplasmic sperm injection who had developed at least five 8-cell embryos, symmetrical cells and showing <11% extracellular fragmentation on day 3 were randomized for day 3 or day 5 transfer. In this prospective, randomized study the implantation and pregnancy potential of embryos transferred on day 3 or day 5 were compared-Results: There was statistically significant difference between day 3 and day 5 transfer regarding clinical pregnancy rates (29.5% versus 66.7%), implantation rates (7.9% versus 34.7%), twinning rates (2.3% versus 11.9%)-Conclusion: Higher significant difference in clinical pregnancies,implantation rate in blastocyst transfer group than cleavage transfer group so it is possible to decide on performing blastocyst transfer when having 5 or more fertilized oocytes with 8-cell embryos, symmetrical cells and showing <11% extracellularfragmentation on day 3, without risking for a transfer cancellation.
Blastocyst
culture
embryo
transfer
2018
12
01
128
133
https://zumj.journals.ekb.eg/article_271153_f47a0f0b241bed9ba86d6fb20864a60b.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
Depression Associated with Hyperemesis Gravidarum among Pregnant Females Attending Zagazig University Hospitals: A Case Control Study
Aya
El masry
Moustafa
Zaitoun
Eman
ALsafi
Nora
Hussien
Amira
EL bahiy
Background: Hyperemesis gravidarum (HG) is characterized by intractable nausea and vomiting, dehydration, large ketonuria, and loss of more than 5% of pre-pregnancy weight. HG adversely affect maternal wellbeing‚ significantly leads to physical, psychological, social consequences and hospitalization. The psychological component of HG remains unclear; and the relationship between HG and psychological problems such as depression is not completely understood. Aim: To assess the relationship between HG and psychological problems mainly depression; and to assess its presence and severity in pregnant women with and without HG. Methods: A case-control study on 26 cases of pregnant women hospitalized with the diagnosis of HG and 26 pregnant women with nausea and vomiting of pregnancy were evaluated as the control group. All patients in the study completed the 24-hour Pregnancy Unique Quantification of Emesis and Nausea (PUQE) ‚ Beck depression inventory (BDI). Results: There was a high statistical significant difference between HG cases and controls regarding frequency of emesis ‚retching and self-evaluation of well-being. Mean of BDI was 30.69±5.4 in HG cases while it was 16.69 ±6.62 in control group (p ˂0.05) with high statistical significant difference. Conclusion: Depression was more common and severe in cases with HG compared with controls.
Hyperemesis gravidarum‚ Depression
Nausea
Vomiting
2018
12
01
134
142
https://zumj.journals.ekb.eg/article_271333_c6cf06974d1fdd311a1a5995ef44779a.pdf
Zagazig University Medical Journal
1110-1431
1110-1431
2018
24
8
IMPROVING THE QUALITY OF LIFE IN CHILDREN WITH CONGENITAL HEART DISEASES ATTENDING OUTPATIENT CLINIC IN ZAGAZIG UNIVERSITY HOSPITAL , EGYPT
Shereen
Awad
Ahmed
Elhewala
Nada
Abdel Azeim
Shahira
Dimetry
Attia
Soliman
Mohammed
Foda
Introduction: Congenital heart diseases are among the most common birth defects and are the leading cause of birth defect-related deaths. In Egypt, it was found that the prevalence of congenital heart diseases was 1.01/1,000 live births. The most common cardiac defects are ventricular septal defects. Children with congenital heart diseases experience decreased health related quality of life. Aim: This study aimed at improving health-related quality of life of the children through applying an educational program about the most important aspects of the disease and how to deal with it. Subjects and methods: An intervention study (pre-post self-control study) was carried out on 54 patients aged (10 – 18 years) with congenital heart diseases by providing health education session to the patient and their parents.The patients were assessed using PedsQL Pediatric Quality of Life Inventory Version 4.0 and PedsQL Cardiac Module Version 3.0 to assess health related quality of life before and after intervention. Results: This study showed that patient education intervention caused significant improvements in all quality of life domains among the patients. Conclusion: Patient education is considered a very effective method that could be applied by health care providers in order to improve the quality of life of children suffering from congenital heart diseases.
quality of life
Congenital heart disease
2018
12
01
143
151
https://zumj.journals.ekb.eg/article_300071_54f31d26cb39dcbf7401f044e88e0774.pdf