Zagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Wernovesky Inotropic Score and it's Relation to Outcome of Critically Ill Patients in Pediatric Intensive Care Unit3583634216610.21608/zumj.2019.10298.1091ENMohamedRomihdepartment of pediatrics, faculty of medicine, zagazig university , Zagazig , EgyptDaliaAbdellatifdepartment of pediatrics, faculty of medicine, zagazig university , Zagazig , Egypt0000-0002-2496-1573Samer AnwarMubarekpediatric department, faculty of medicine, zawia univercity Zawia, LibyaJournal Article20190310Background: Hemodynamic instability is defined as any instability in blood pressure which can lead to inadequate arterial blood flow to organs.Wernovsky-inotropic score (WIS), a measure of post-operative cardiovascular support, has been associated with morbidity and mortality after infant cardiac surgery in prior center studies.<br />Objectives: This study aimed to determine the association of Wernovsky-inotropic score (WIS) with clinical outcome of critically ill children with hemodynamic instability in PICU and to use it as a predictor of the outcome of the critically ill patients.<br /> Patients & Methods:This study was prospective analytical study which conducted at pediatric intensive care unit (PICU) at Pediatric Department, Zagazig University Hospital on 102 patients during the period of 10 months from april 2018 to January 2019. <br />Results: On studying relationship between WIS score over time and patient outcome, WIS didn’t statistically significantly differ between dead or discharge patients at baseline, 6 and 12 hours. While there is significant difference between both groups at 24 and 48 hours.<br />Conclusions: Wernovssky-inotrpic score (WIS) is an easily calculated clinical score. It is useful as an independent predictor of clinical outcomes of critically ill pediatric patients with hemodynamic instablility in PICU. WIS is a reliable marker of cardiovascular support that may be used as a surrogate outcome for research studies and provide additive value to existing pediatric acuity scores in this population.<br />Keywords: Wernovesky-Inotropic Score.https://zumj.journals.ekb.eg/article_42166_71b029502393c56e88129649c6a71b8f.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501COMPLIANCE OF EGYPTIAN MOTHERS TO ASTHMA CONTROLLERS36437434162ENKhalid AmerMesbahDepartment of pediatrics ,faculty of medicine, Tripoli UniversityTarek HamedAttiaPediatrics department, faculty of medicine, Zagazig University, Zagazig, Egypt.Mohamed AhmedArafaPediatrics department, faculty of medicine, Zagazig University, Zagazig, Egypt.Journal Article20190312Objective:Evaluation of compliance of asthmatic children and their mothers through assessment of mother''s knowledge, attitude,practices and behavior regarding bronchial asthma and its management at Pediatric Outpatient Clinic at Zagazig University Hospitals.<br />Methods: A cross-sectional study was conducted during the period from April 2018 to January 2019 at Pediatric Outpatient Clinic at Zagazig university Hospitals. The study included 137 mothers of asthmatic children. Data were collected by detailed History, full examination,PFTs and a structured interview questionnaire included: demographic data of the mothers and their asthmatic children, Assessment of asthma triggers, Asthma Knowledge Questionnaire, Modified Asthma Self-Management Questionnaire, and Morisky Medication Adherence Scale.Results: stress, cold illness and pesticides were the most common asthma triggers in the present study. Only 37.2% of the studied mothers had adequate knowledge about asthma. Rural residents, mothers with high education and working mother had significantly more adequate knowledge about asthma. Compliance among the studied mothers was not satisfactory as only 32.1% of them had adequate compliance. Urban residents, mothers with secondary education andhousewives had significantly more adequate compliance. Mothers of children with moderate to severe asthma had significantly higher compliance level. Less absenteeism was associated with adequate compliance of mothers. There was a statistical significant positive correlation between children compliance score and disease duration. <br />Conclusion: In the present study, there were lack of asthma self-management, knowledge and compliance.Stress, cold illness, pesticides, air pollution, sports, clutter, and Gasoline were the most common asthma triggers in the present study.https://zumj.journals.ekb.eg/article_34162_aa8fdf36fbc32e2bb7f49e872844ecea.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501ROLE OF PRESEPSIN IN PREDICTING THE SEVERITY AND OUTCOME OF COMMUNITY ACQUIRED PNEUMONIA IN PEDIATRICS.3753834072110.21608/zumj.2019.10906.1138ENMohamed ZakiAbdallah AbdelmoatyPediatric department faculity of medicine zagazig universityMohammedNagiubpediatric department faculty of medicine zagazig universityMohamed AhmedArafapediatric department faculty of medicine zagazig universityAtef GodaHusseinmedical biochemistry,faculty of medicine ,zagazig university,egyptJournal Article20190326Abstract<br />Background: The aim of this study was to investigate the role of presepsin in evaluation of severity and outcome of community –acquired pneumonia in pediatric department of Zagazig University hospitals.<br />Methods: A prospective case control study was carried out at the pediatric Department of Zagazig University Children Hospitals during the period from February 2017 to October 2017.<br />Results: there was statistically significant difference between case and control groups in Preserpin level, there is statistically significant difference in presepsin level between cases that need Icu dmission and M.V. and cases treated in ward only without need for Icu admission and M.V, therewas statistically significant difference in presepsin level between survivors and non-survivors. In this study, there was statistically significant difference in presepin level with disease severity.in which presepsin is higher in severe than moderate and mild cases. we tried to detect the cutoff point of presepsin to detect the community acquired pneumonia calculated from ROC curves it was > 0.8 (ng/ml), and the area under the curve of presepsin was 0.833 with senstivity 97.8% and specificity 72%.<br />Conclusion Presepsin is a useful diagnostic and prognostic marker for pneumonia in Pediatrics. The present study suggests that Presepsin is a promising biomarker for reflecting the severity of Community- Acquired Pneumonia. Presepsin in combination with PRESS score may improve the predictive accuracy for severity and outcome of community acquired pneumonia in pediatrics.<br />Corresponding author:<br />Name: Mohamed Zaki Abdallah, Tel:01016532687, Email:mzakimzaki231@gmail.comhttps://zumj.journals.ekb.eg/article_40721_fa9894e3dd1e2fe69172228be9e9bded.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Bacterial Contamination of Healthcare Workers’ Mobile Phones in Pediatric and Neonatal Departments of Two Hospitals in Zagazig City3843964568410.21608/zumj.2019.13773.1263ENMohamedBakrypediatrician , pediatrics department ,faculty of medicine , zagazig university, zagazig , egyptTarekAttiaprofessor of pediatrics,pediatrics department ,faculty of medicine, zagazig university,zagazig ,egyptOsamaAmerprofessor of pediatrics ,pediatrics department, faculty of medicine ,zagazig university, zagazig , egyptAhmed MoradAsaadMicrobiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt0000-0002-1422-1117Journal Article20190622Introduction: Nosocomial infections (NIs) are one of the leading causes of mortality and morbidity in neonatal intensive care units (NICUs) and pediatric intensive care units (PICUs). The incidence of infections varies widely among NICUs (7-25.5%), and (18-30%) among PICUs depending on environmental factors and differences in clinical practice (Brito et al., 2010).<br />Objective: To investigate the prevalence of bacterial contamination of mobile phones of HCWs in pediatric departments (ward, NICU and PICU) of Zagazig University Hospital and Al-Mabarrah General Hospital. To characterize a baseline of data on types of bacterial isolates and their antibiotic sensitivity patterns. <br />Methods: The study was conducted at Zagazig university hospital NICU and PICU and Al Mabarra hospital NICU in the period from April 2018 to october 2018. This prospective cross sectional study was approved by The Research Committee of Faculty of Medicine. The study was conducted according to the guidelines of Helsiniki Decloration (world medical association 2013)<br />Results: This cross-sectional study included 350 HCWs , of whom 38 HCWs were from El-Mabara hospital , while the rest from Zagazig university hospital the HCWs were between 21 and 56 years with a median age of 31 years and the number of females was 274 ; 78.3% <br />Conclusion: Use mobile phones by HCWs during the work in the NICUs and PICUs carry ahigh risk for the NIs. Bacterial contamination of the mobile phones of the HCWs. Regular cleaning of the phones decrease the contamination rate.https://zumj.journals.ekb.eg/article_45684_1bb27bedb17ad5af999140255285e382.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Assessment of copeptin levels in children with type 1 diabetes3974044469010.21608/zumj.2019.14517.1322ENMohamed SalahFathallaPediatrics department, Faculty of Medicine, Zagazig universityHossam MostafaKamalpediatrics department, faculty of medicine, zagazig universityAhmed MohamedGab~AllahClinical Pathology Department, Zagazig University Hospitals, Zagazig, EgyptJournal Article20190710Abstract<br />Background: Children with type 1 diabetes are in risk of developing renal complications as a part of microvascular complications on the long run, early diagnosis of these complications can decrease morbidity and mortality of these complications. Copeptin has shown association with development of chronic kidney disease (CKD) in people with diabetes.<br />Methods: This is a case - control study was conducted at Zagazig University Hospital of pediatrics from June 2017 to January 2018 on 40 cases suffering from T1DM. It also included 40 matched healthy controls who attend outpatient clinics for routine care.<br />All cases were subjected to a complete clinical study (thorough history and physical examination) upon study inclusion, with emphasis on symptoms and signs of diabetes and renal affection.<br />The following investigations were performed: HbA1c, Urine analysis, Albumin/creatinine ratio, renal function test (creatinine, BUN) Renal Ultrasound, Measure serum copeptin level by ELISA (Sandwich technique).<br />Results: Our study showed that there is a significant increase in serum copeptin levels compared to healthy group. There is no significant difference between poorly controlled and well controlled children with T1DM regarding copeptin levels. Serum copeptin has also a positive correlation with albumin/creatinine ratio in children with T1DM.<br /><br />Conclusion: Serum copeptin is a potential prognostic biomarker in childhood diabetic renal affection.https://zumj.journals.ekb.eg/article_44690_d896fe534d832f60a3cb328dd3e7cdc4.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Polymorphism of Toll-like receptors type 2 gene in Neonatal sepsis in NICU of Zagazig University Children Hospital4054134188310.21608/zumj.2019.14651.1324ENAhmedHassanPediatric department, Faculty of medicine, Zagazig University, Zagazig, EgyptTarek HamedAttiaPediatrics department, faculty of medicine, Zagazig University, Zagazig, Egypt.WessamMokhtarprofessor of pediatrics, faculty of medicine, zagazig universityAhmed ElsadekFakhrMicrobiology and Immunology Department0000-0002-0497-4908Journal Article20190710Introduction: Neonatal sepsis is a major cause of morbidity and mortality among newborn infants. Sepsis is a complex syndrome that is initiated by infection and is characterized by a systemic inflammatory response. The inflammatory cascade is a complicated process that involves humoral and cellular responses, complement, and cytokine cascades. Recently, genetic variation in crucial genes in the inflammatory response and coagulation pathways has been the focus for innovative research aiming to elucidate the mechanisms behind sepsis, in particular, identification of genetic variation in TLRs.<br />Objectives: to investigate the association between the prescence of certain genetic polymorphisms of toll-like receptor type 2 genotype and risk, severity, prognosis and outcome of gram-positive bacterial sepsis in neonates in NICU at Zagazig University Childern Hospital. <br />Methods: This is a case–control study , 72 subjects were included in the present study divided into two groups; group I : 36 healthy newborns as control group, group II: 36 bacteremic cases with early or late onset neonatal sepsis. For Detection of TLR2 (Arg753Gln) polymorphisms, blood specimens were collected in vacutainer tubes containing EDTA then DNA extraction was performed and determination of the TLR 2 gene polymorphisms was accomplished by PCR followed by RFLP.<br />Results: TLR2 (Arg753Gln) polymorphism was detected in 3 subjects (8.3%) in the sepsis group, while it was not detected in the control group <br />Conclusion: There is no significant association between TLR2 Arg753Glu polymorphism and severity or prognosis of gram-positive bacterial sepsis in neonates.https://zumj.journals.ekb.eg/article_41883_557e8190fa7cad26d97086588fc8f4b0.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Assessment of Kidney Status in Cardiac Children Treated with Angiotensin Converting Enzyme Inhibitors4144224468910.21608/zumj.2019.14715.1329ENDoaa MohammedYoussefpediatrics, faculty of medicine, zagazig university
Postal Code: 44519
info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt0000-0001-9948-5690EzzatKamelpediatric nephrology unit , zagazig university, Egypt
Postal Code: 44519
info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - EgyptAzzaKhalilpediatric department
Postal Code: 44519
info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - EgyptTarekAyyatpedaitric departemnt
Postal Code: 44519
info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - EgyptJournal Article20190713Background: Angiotensin Converting Enzyme Inhibitors (ACEIs) are commonly used to treat many cases especially chronic heart failure and there is different data about kidney affection in those patients, we aimed in this study to evaluate the kidney status in patients using this medication weather on chronic bases or recently added.<br />Patients and methods: We studied 50 cardiac children 15 of them with old treatment with ACEIs group A, 15 of them with new treatment with ACEIs group B and 20 of them not use ACEIs as a control group as group C, all patients were subjected to detailed history taking including demographic data, Glomerular filtration rate calculated For children by modified Schwartz method in addition to Routine test of kidney function.<br />Results: There was statistically significant higher creatinine level and lower eGFR in group A and B than control group, there was 40% of patients on old ACEIs treatment suffered from metabolic acidosis and increased creatinine level in blood compared to (10% and 20% among group B, 5% and 0% among group C respectively), while 50% of group A suffered of hyperkalemia and decreased GFR versus 20% among group B and 5% among group C respectively, and the difference between groups was statistically significant. There was a statistically significant negative correlation between duration using ACEIs and GFR and urine output, <br />Conclusion: We concluded that there is high risk of renal impairment in cardiac children treated with ACEIs and this risk is higher with increasing duration of therapy with these drugshttps://zumj.journals.ekb.eg/article_44689_8c74a164637d064d1cabb7f362d51a49.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Assessment of B-cell Activating Factor (BAFF) in children with Acute Lymphoblastic Leukemia4234335716410.21608/zumj.2019.17149.1529ENOla AlyHusseinclinical pathology department,faculty of medicine,zagazig university,zagazig,egyptMervat AtfyAtfy M. AliPediatric hematologyGhada MohamedEl-akadclinical pathology departement,faculty of medicine,zagazig university,zagazig,egyptNahlaZidanClinical Pathology Department, Faculty of Medicine,Zagazig University, Zagazig, EgyptAsmaa HassanBehairyclinical pathology department,faculty of medicine,zagazig university,zagazig,egyptJournal Article20190923Background:Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. BAFF is member of TNFSF13B whose level is elevated in cases of ALL. Aim: To assess serum BAFF level in children with ALL and correlate its level with the clinical, laboratory findings and known prognostic factors as well as its relation to response to treatment.Subjects and Methods: This study was conducted at Zagazig University Hospitals in the period from April 2018 to June 2019 on 24 Egyptian children with newly diagnosed ALL and 24 apparently healthy children of matched age and sex as a control group. Patient history, clinical and laboratory examination results were taken, including complete blood count, bone marrow aspiration with cytochemistry, immunophenotyping, and estimation of serum BAFF level using ELISA kits.Results: We found statistically significant higher BAFF levels among de novo childhood acute lymphoblastic leukemia patients compared with the apparently healthy control group (P value < 0.0001).High serum BAFF was significantly correlated to patients’ poor treatment response(P value < 0.05) but not patients’ outcome (P value > 0.05).Conclusion: We found a significant relation between serum BAFF level and response to treatment so assessment of serum BAFF level at the time of diagnosis may be a predictor for response to treatment. This finding recommends that patients with high BAFF level at the time of diagnosis be subjected to intensified course of therapy.https://zumj.journals.ekb.eg/article_57164_e29110ddc6374edf9063a351e22484dc.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Effect of Percutaneous Coronary Intervention on Blood Pressure in Patients with Hypertension and coronary Heart Disease in Zagazig University Hospitals4344413637510.21608/zumj.2019.11323.1203ENFouzi SalimAmsheericardiology .zagazig unversityMahmoud HassanShahProfessor of Cardiovascular medicine Faculty of Medicine – Zagazig University, EgyptTamer MohamedMoustafaProfessor of Cardiovascular medicine Faculty of Medicine – Zagazig University, EgyptAhmed SaidEl-damanhoryLecturer of Cardiovascular medicine Faculty of Medicine – Zagazig University, EgyptJournal Article20190426Background: Coronary artery disease (CAD) is a major cause of morbidity and mortality over the world. The atherosclerosis can developed through many years and symptoms occur, generally in middle age. The risk of developing CAD increases with age including age >45 years in men and >55 years in women. Objectives: The presented study was aimed to evaluate the dynamic changes of systolic and diastolic blood pressure in hypertensive patients with ischemic heart disease pre and post percutaneous coronary intervention (PCI), and to determine the effects of PCI on the elevated blood pressure on the CAD patients. Patients & Methods: Our study had been carried out in cardiology department, Zagazig University from October 2017 to September 2018. This study included 100 patients with hypertension and coronary artery disease. The patients were subjected for complete history taking, clinical examination, elective PCI and ambulatory blood pressure monitoring before and one month after PCI. Results: Results showed a highly significant difference between the ambulatory blood pressure pre and after coronary intervention, a significant decrease in the mean values of SBP and DBP (140/84 mm Hg) and the percentage of changes in BP after PCI revealed more decrease at night in the mean values of SBP and DBP compared with percentage at day. Conclusions: PCI is efficiently control and improve the blood pressure among hypertensive patients with CAD.https://zumj.journals.ekb.eg/article_36375_7fa1c5d19f1abaf7db41201e1c945efa.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Association Between Morning Blood Pressure Surge and Microalbuminuria in Normotensive Type 2 Diabetic Patients.4424494360310.21608/zumj.2019.14588.1320ENAbdel-Rahman OsamaAbdel-KareemCardiology department, zagazig university, zagazig, Sharkia, EgyptRagab AbdelSalamMahfouzCardiology department, zagazig university, zagazig, Egypt.Ismail MohammedIbrahimCardiology department, zagazig university, zagazig, EgyptIslam El-SayyedMohammedCardiology department, zagazig university, zagazig, EgyptJournal Article20190715Abstract<br />Background: The slight fluctuations in blood pressure (BP) regulation even without advancing to abnormal values appear to be related to more accelerated cardiovascular complications in patients with type 2 diabetes mellitus (T2DM). Morning blood pressure surge (MBPS) has been increasingly reported to provide a significant predictor of cardiovascular disease (CVD) risk.<br />Aim: To study the whether MBPS is associated with increased levels of microalbuminuria in normotensive T2DM patients.<br />Patients and methods: Normotensive T2DM patients were subjected to ambulatory blood pressure monitoring (ABPM) and urine spot sampling to assess urine albumin creatinine ratio (UACR).<br />Results: 32% of patients had microalbuminuria with a highly significant moderate positive correlation between UACR with DM duration, MBPS and average 2-hours systolic blood pressure (SBP) with (r = 0.342) p-valuehttps://zumj.journals.ekb.eg/article_43603_0c0ee10c400239da587e0b306386c373.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Is Oral Anticoagulant with High dose in Pregnant Women with Prosthetic Mechanical Valve Effective and Safe?4504547787510.21608/zumj.2020.23331.1717ENMohammadEltahlawiCardiology Department, Faculty of Medicine, Zagazig UniversityMohammadAlanwarDepartment of Cardiothoracic surgery, Faculty of Medicine, Zagazig UniversityNezarElnahalCardiothoracic Surgery, Faculty of Medicine, Zagazig UniversityAmirAbdelsayedCardiothoracic Surgery, Faculty of Medicine, Zagazig UniversityMarwaTharwatDepartment of Anatomy & Emberyology, Faculty of Medicine, Zagazig Universityoooo-0003-0664-0060Journal Article20200203Background: The management of women with prothetic valves in pregnancy remains challenging. Anticoagulation in these subgroups has many controversies.<br />Aim: We aim to evaluate the safety dose of oral anticoagulant in pregnant women with mechanical valve prosthesis in first trimester.<br />Patients &Methods: Pregnant ladies with well functioning prothetic valves were enrolled. Patients were divided into 3 groups: Group A took oral anticoagulant < 5 mg warfarin with therapeutic INR. Group B took low molecular weight heparin (LMWH) twice daily and monitoring is done every week by antifactorXa 4-6 hours post-injection to keep about 1 IU/ml. Group C took oral anticoagulant in dose > 5 mg warfarin to reach therapeutic INR.<br />Results: There was significant difference between groups in vaginal bleeding and abortion, with more bleeding and abortion in group Busing LMWH. There was a high rate of malfunction valve about 19.9% in group B, but no reportedcases of malfunction valve in the other both groups using warfarin.<br />Conclusion: Warfarin with dose > 5 mg in pregnant women with mechanical prosthetic valve is as safe for mother and baby as warfarin with dose < 5 mg. Both regimens are safer than LMWH.https://zumj.journals.ekb.eg/article_77875_58696f183587749ade1ccc89a76f647c.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Is Platelet Rich Plasma (PRP) Injection in Sternotomy Wound Better for Healing and Pain Control?4554648229110.21608/zumj.2020.26772.1788ENMohamed I.AlanwerCardiothoracic Surgery Department, Faculty of Medicine, Zagazig University, Zagazig , Egypt.Mohamed MaherAllamCardiology Department, Faculty of Medicine, Zagazig University, Zagazig , Egypt.Khaled MostafaHelmyDepartment of Anesthesia and surgical intensive care, Faculty of Medicine – Zagazig University, , Zagazig , Egypt.Journal Article20200401Background: Superficial and deep sternal wound infections (SWI & DSWI) post-cardiac surgery increase morbidity and hospital stay. Autologous platelet rich plasma (PRP) derived from the patient’s own blood has been used in other surgical settings to promote successful wound healing. The aim of this work was to evaluate the usefulness of Platelet Rich Plasma (PRP) injection in sternotomy wound of patients undergoing cardiac surgical procedures. Patient and methods: A prospective study for patients underwent open heart surgery from June 2013 until June 2016 at Zagazig University. One hundred sixty patients were divided into two groups; group A: there is application of PRP before and after sternal closure in about 80 patients and group B: Sternotomy closure by ordinary manner without application of PRP in 80 patients. Results: Mean age was 54.32±8.005 in group (A), ranged from 30 to 72 years and in group B, mean age was 55.21±9.06, ranged from 28 to 70 years. Follow-up of postoperative SSWI and DWSI showed that the use of PRP had no adverse reactions in our study. Also, the incidence of superficial and deep sternal wound infection from one month to more than 3 months in group A was reduced. Postoperative pain in group A had a significantly low incidence of moderate and severe pain in the period from one month to more than 3 months. Conclusion: The application of PRP in sternotomy wound was found to be simple, safe and significantly reduced postoperative infection rates and pain severity in the treatment group.https://zumj.journals.ekb.eg/article_82291_c40ba7ab52086c252e270149627d5480.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Lipid Profile Disorder among patients with type 2 diabetes mellitus.4654733603810.21608/zumj.2019.11948.1201ENGehan AbdelkaderIbrahimInternal Medicine Department, Faculty of Medicine, Zagazig University, Sharkia EgyptAmany MohammedAbdAllahFamily Medicine department, Faculty of Medicine, Zagazig university, EgyptAhmed El-sayedHassaninResident of Family Medicine, South Sinai directorate of health, Ministry of health, EgyptJournal Article20190420Background<br />Type 2 diabetes mellitus (T2DM) is a notable disease in developing and/or developed countries associated with a high risk of morbidity form cardiac disease. It has been proposed that the composition of lipid particles in diabetic dyslipidemia is more atherogenic than other types of dyslipidemia. The aim of our study was to identify the relation between T2DM and the lipid profile disorders and identify the factors associated with increasing the risk of dyslipidemia in patients with T2DM.<br />Method:<br />We conducted an epidemiological cross-sectional study in DM Clinic in comprehensive health insurance clinic Tur Sinai District in Egypt. We included patients with T2DM, patient age from 18 to 60 years old, and apparently uncomplicated. <br />Results: <br />We enrolled 94 patients with T2DM with mean age of 49.5 ± 9.12 years. Of whom, 42 (44.7%) were male and 52 (55.3%) were females. About 55% of the studied patients had dyslipidemia. On assessing each item in lipid profile, (53.2%) of the studied patients had abnormally high triglycerides level, 46.9% of them had hypercholesterolemia, 45.9% had abnormal LDL-cholesterol level and 25.5% of them had low HDL level. Fasting blood glucose and glycosylated hemoglobin were significantly higher among DM patients with dyslipidemia. <br />Conclusions: <br />This study highlighted high prevalence of dyslipidemia associated with DM. The present study also highlights the importance of strict control of DM in prevention and treatment of dyslipidemia as dyslipidemia is more frequent in uncontrolled diabetic patients and decreasing BMI and absence of hypertension can protect against the risk of dyslipidemiahttps://zumj.journals.ekb.eg/article_36038_490e6fe4866fce01a1efb4237e6eee2c.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Serum and Urine Neutrophil Gelatinase- Associated Lipocalin: As an Indicator for Early Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients4744824511410.21608/zumj.2019.13529.1249ENOmar Mohamed El SayedAbd El KaderInternal medicine,faculty of medicine,Zagazig university,Zagazig,egypt1234-1234-1234-1234Mabrouk IbrahimIsmailinternal medicine,faculty of medicine,zagazig university,zagazig,egyptMaher MohamedBoraiclinical pathology,faculty of medicine,zagazig university,zagazig, egypt0000-0000-0000-0000Walid AhmedRagabinternal medicine,faculty of medicine,zagazig university,zagazig,egypt0000-0001-6146-9775Journal Article20190617Abstract<br />Background: Diabetic Kidney Disease (DKD) represents the major cause Chronic Kidney Disease (CKD) where 5- 40% of patients with Type 2 Diabetes Mellitus (T2DM) ultimately develop DKD. CKD diagnosis is reliable on levels of blood urea nitrogen and serum creatinine, however, serum creatinine has a low predictive value in early detection of renal impairment. So, new biomarkers for early diagnosis of CKD is of interest. Objectives: Elucidate the significance of Neutrophil Gelatinase- Associated Lipocalin (NGAL) as an early predictor of diabetic nephropathy in comparison with albuminuria in (T2DM). Patients and Methods: Prospective, case control study, carried out on patients with T2DM with a duration of disease ranged from (5-15) years, presented to outpatient clinics of nephrology and endocrinology units of internal medicine department in Zagazig University hospitals from August 2018 to February 2019., The study included (100) participants divided into : group (A) 25 healthy control , group (B) 75 diabetic type 2 patients stratified into three subgroups according to albumin / creatinine ratio: subgroup (1) : 25 normoalbuminuric ,subgroup (2): 25 microalbuminuric subgroup (3) : 25 macroalbuminuric. Results: there was statistically significant difference between healthy individuals, normo, micro and macroalbuminuria diabetic patients regarding serum NGAL (sNGAL) & urinary NGAL (uNGAL),where their levels incremented parallel to the degree of albuminuria . Conclusion: tubular injury may precede glomerular injury in diabetic patients and As NGAL is a tubular marker , So NGAL is superior to albumin / Creatinine ratio(ACR) as an early predictor of DKD among T2DM patients .https://zumj.journals.ekb.eg/article_45114_add00cd0c219d62395d81531683a7d38.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501POTENTIAL ANTIEPILEPTIC EFFECT OF IVABRADINE AGAINST PENTYLENETETRAZOLE INDUCED- KINDLEING IN MALE MICE4834923076810.21608/zumj.2019.11284.1174ENHeba SabryAhmedAssistant lecturer, clinical pharmacology department, faculty of medicine, zagazig universityAhmed AhmedAbdelsameeAssistant professor of clinical pharmacology, clinical pharmacology Department, Zagazig University, Zagazig, Egypt, E mail :0000-0003-1142-9753Elsayed MohamedKamelclinical pharmacology department ,faculty of medicine, zagazig universityJournal Article20190330Background: Ivabradine, Hyperpolarization activated cyclic nucleotide gated (HCN) channel blocker, is the most specific blocker of central nervous system Ih current. Valporate is one of the most commonly used antiepileptic drugs.<br />Objectives: investigate the possible anticonvulsant effect of Ivabradine and its interaction with valporate in pentylenetetrazole (PTZ) induced- kindling in mice. <br /><br />Materials& Methods: mice were divided into four groups, “Group 1", "vehicle-treated group" <br />“Group 2", "PTZ kindling Control group "Group 3: Ivabradine ", group 4 Valproate (VPA) group 5" Ivabradine and VPA. Kindling was produced by repeated intraperitoneally (i.p). administration of PTZ (40mg/kg), every other day for 9 doses. Both drugs were administered i.p., 30 minutes before each PTZ injection. Seizure score, latency were recorded. Their brains were removed for assessment of oxidant/antioxidant status and anti-inflammatory cascades.<br />Results: Ivabradine and VPA individually significantly decreased seizure score and co administration of both drugs significantly decreased seizure score less than either vaporate or Ivabradine. Both drugs significantly increased latency to seizures. <br />Ivabradine, VPA and their combined administration significantly elevated brain level of GSH, catalase and significantly decreased levels of nitrite, MDA, IL1β, and TNFα as compared to PTZ control group. Co-administration of both drugs resulted in a significant elevation in the brain level of GSH, catalase concomitant with a significant reduction in the brain levels of MDA, IL1β and TNFα as compared to either VPA or ivabradine groups. <br />Conclusion: Ivabradine has anticonvulsant effect and potentiates the effect of VPA which may be attributes to HCN channel blockade, antioxidant and anti-inflammatory effects.https://zumj.journals.ekb.eg/article_30768_2a751bc8d58177d8d01957be95f5d847.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Prevalence and risk factors of overweight and obesity among primary school children in Hawally District, State of Kuwait4935014473610.21608/zumj.2019.14245.1298ENAli NofalAlenzicommunity Medicine,Faculty of Medicine,Zagazig UniversityHosnia RagabMohammedcommunity Medicine,department,faculty of medicine, zagazig universityAlsayed HasanAbdalhameedcommunity Medicine,department,faculty of Medicine,zagazig UniversityAmiraE. Abdelsalam.Assistant Professor of public health and community medicine Department of Community Medicine, Faculty of Medicine, Zagazig University, Zagazig, EgyptJournal Article20190708Background: Obesity and overweight are serious epidemic issues worldwide in general and in Middle East countries including the state of Kuwait especially due to multiple risk factors like sedentary lifestyle activity. Objectives: To estimate the prevalence of overweight and obesity among primary school children in Hawally District, State of Kuwait and to determine identify risk factors associated with them. Methods: The study surveyed 143 and children aged 6–12 years in 4 selected public schools. Questionnaires were developed to elicit information from parents' and their children's perceptions of weight status, physical activities, sedentary activities, daily food intake as well as their attitudes toward overweight and obesity in general. The children’s body mass index (BMI) was measured according to the Center for Disease Control’s (CDC) guidelines. Results: One quarter of the surveyed children (35.0%) were overweight. An additional one third of the participants (17.4%) were classified as obese. There was a high statistical significant association between dietary habits and lifestyle with the BMI of children. Lack of Physical exercise, watching television ˃ 2 hours/day was associated with overweight and obesity. Conclusion: This study demonstrated a relatively high prevalence of overweight and obesity among primary school children aged 6–12 year-old in state of Kuwait. Socioeconomic class, faulty dietary habits, sedentary life style, low level of physical activity were the most important risk factors.https://zumj.journals.ekb.eg/article_44736_80c19047415acb550de08b074cb29e2b.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Role of Mean Platelet Volume in the Prognosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients5025093719910.21608/zumj.2019.11027.1218ENMohammed AliEltaweelchest department faculty of medicine zagazig university Zagaig egyptMaha MohamedAbdel-Kader El-GabryProfessor of Chest Diseases Faculty of Medicine - Zagazig UniversityMostafa IbrahimMohamed RagabProfessor of Chest Diseases Faculty of Medicine - Zagazig UniversityDoaa MostafaMohammedAssistant Professor of Chest Diseases Faculty of Medicine - Zagazig UniversityJournal Article20190512Background: COPD represents an important public health challenge and is a major cause of chronic morbidity and mortality throughout the world, where COPD are associated with an increase in airway and systemic inflammation. Aim of this study: the aim of this study was to assess the role of MPV as a marker of inflammation in COPD patients and to evaluate its role as a prognosis parameter in AE COPD. Patients and Methods: This study was carried at Chest Department of Zagazig University Hospitals, during the period from April 2017 till October 2017, the study included 25 stable and 25 exacerbated chronic obstructive pulmonary disease (COPD) patients, selected in non randomized manner. Results: showed that there was no significant statistical difference in RBCs, hemoglobin and hematocrit content and a highly statistical significant increase in white blood cells (WBCs) count, neutrophils count, while lymphocytes shows significant statistical increase among the studied groups. The results showed that the Validity of MPV cutoff value, Sensitivity was 76.0%, Specificity was 80.0%, +VE predictive was 79.1%, -VE predictive was 76.9% and the accuracy was 78.0%.Conclusion: MPV is an easily accessible low cost marker of inflammation in AECOPD. Decreased MPV values may be used as indicator for negative acute-phase reaction in the exacerbated COPD patients. Cut off-point of MPVhttps://zumj.journals.ekb.eg/article_37199_bb1f12c8743fecdd3cad981ab8f6d5e7.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients5105163615710.21608/zumj.2019.12936.1230ENImanKandilrheumatotlogy and rehabilitation departement,zagagzig university hospitalsMohammadElgawishRheumatology and Rehabilitation Departement,Faculty of medicine,Zagazig University,EgyptAsmaaEshClinical Pathology Departement,Faculty of medicine,Zagazig University,EgyptMarwaHammadRheumatology and Rehabilitation
Faculty of medicine0000-0003-0328-2325Journal Article20190520Background: The use of antimullerian hormone (AMH) as a marker of ovarian reserve may contribute to treatment decisions regarding the use of medications with known gonadotoxic effects. This study aimed to assess ovarian reserve by measuring AMH level in premenopausal SLE patients. Subjects and methods: A case control study, included 60 female subjects (30 SLE patients and 30 apparently healthy subjects). Full history taking and examination were carried out in Rheumatology and Rehabilitation Department. Laboratory investigations were conducted in Clinical Pathology Department, Faculty of Medicine, Zagazig University Hospitals. Antimullerian hormone level was measured in both patients and controls. Results: The study included 30 SLE female patients whose ages ranged from 19-50 years with a mean of 32.23 ± 8.846 years. The control group composed of 30 healthy female volunteers, whose ages ranged from 18 - 42 years and a mean of 29.03 ± 7.837 years. The mean of the disease duration was 6.87 ± 4.313 years. The study showed that the median of AMH level in SLE group was 2.7 (0.1-9.7) vs. 3.07 (0.3 – 20) in the control group, p value = 0.146 (P>0.05), therefore there was no statistically significant difference between both groups regarding AMH levels or between serum AMH and different drug use. Conclusion: AMH did not differ between SLE patients and controls & was not affected by the disease duration or activity. Moreover, immunosuppressive agents such as cyclophosphamide, azathioprine and mycophenolate mofetil did not significantly affect the AMH levels in SLE patients.https://zumj.journals.ekb.eg/article_36157_163873dc486a275b2fda21387a441f32.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity5175234076510.21608/zumj.2019.13587.1252ENIbrahimElgharibDermatology,venereology&Andrology Department,Faculty of Medicine,Zagazig University,Zagazig,EgyptNaglaaKhalifaDepartment of Clinical Pathology,Faculty of Medicine,Zagazig University,Zagazig, EgyptOlaElasserDermatology,venereology&Andrology Department,Faculty of Medicine,Zagazig University,Zagazig,EgyptMohamedElGhareebDermatology,Venereology&Andrology Department, Faculty of Medicine, Zagazig University,Zagazig,EgyptDoaaHosnyDermatology, Venereology & Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.Journal Article20190624ABSTRACT<br />Background: Endocan is a specific molecule of human endothelial cell. It was accepted as a marker of endothelial dysfunction that is widely involved in psoriasis development. Our aim was to evaluate the relation between serum endocan levels and severity of psoriasis vulgaris . <br />Methods: Twenty-two patients with psoriasis vulgaris were involved . We measured serum endocan, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Psoriasis severity was evaluated by Psoriasis Area and Severity Index (PASI) score. <br />Results: The mean serum level of endocan was 154±49.3 pg/ml with a range from 59 to 210 pg/ml. Its level was statistically significant increase in moderate and severe psoriatic patients compared to mild psoriatic patients. No statistically significant correlations were detected between serum endocan and CRP (P=0.11) and ESR(P=0.16). In contrast, a very highly statistically significant positive correlation was detected between endocan and disease severity(p=0.001). <br />Conclusions: Serum endocan can be a promising marker that correlates with psoriasis vulgaris severity.https://zumj.journals.ekb.eg/article_40765_ad304fd4d92ab00f48ef397fce2482b9.pdfZagazig University, Faculty of MedicineZagazig University Medical Journal1110-143126320200501CHILDHOOD ATTENTION DIFICIT HYPERACTIVITY SYMPTOMS AMONG ADULT PATIENTS WITH OBSESSIVE COMPULSIVE DISORDER AT ZAGAZIG UNIVERSITY HOSPITALS5245334355910.21608/zumj.2019.14329.1306ENLamisIbrahimPsychiatry Department, faculty of medicine, Zagazig university, Zagazig,EgyptWa_ilAbohendyPsychiatry department,faculty of medicine,Zagazig university,Zagazig,EgyptNellyRaafatPsychiatry, Zagazig UniversityAmiraFouadPsychiatry department,faculty of medicine,Zagazig university,Zagazig,EgyptJournal Article20190708Background: Obsessive–compulsive disorder (OCD) and attention-deficit and hyperactivity disorder (ADHD) frequently coexist. Childhood ADHD symptoms have negative impact of on the clinical presentation of OCD. Our aim is to evaluate the prevalence of childhood ADHD symptoms among OCD patients and the effect of this on clinical characteristics of the disorder. Methods:. We applied the Structured Clinical Interview for DSM-V to diagnose OCD on 100 OCD patients fulfilling our inclusion criteria .The Arabic-translated and validated version of the Wender Utah Rating Scale (WURS), was used to retrospectively assess childhood ADHD symptoms.The severity of OCD was assessed by the Yale–Brown Obsessive Compulsive Scale (Y-BOCS), severity of depression was assessed by the Hamilton Depression Rating Scale-17 (HDRS) and severity of anxiety was assessed by the Hamilton Anxiety Rating Scale (HAM-A). Barratt Impulsiveness Scale-11 (BIS-11) was used to assess impulsiveness . The adult ADHD was measured by the adult ADHD self-report scale Symptom Checklist. Results: 44% of the OCD patients had ADHD symptoms since childhood. Patients with childhood ADHD symptoms had an earlier onset of OCD, higher levels of depression, anxiety and impulsiveness. The scores of the Y-BOCS did not differ significantly between those having and not having childhood ADHD symptoms. Conclusion: Childhood history of ADHD symptoms is common in adult OCD patients. Childhood ADHD symptoms are associated with an earlier age of OCD, more severe depression, anxiety and higher impulsiveness.https://zumj.journals.ekb.eg/article_43559_c2f25abccf2fc08e95a29b2e496717e5.pdf