EFFECT OF NITRIC OXIDE IN CHRONIC EXPERIMENTAL TOXOPLASMA GONDII INFECTION: HISTOPATHOLOGICAL AND HISTOCHEMICAL STUDY

Document Type : Original Article

Authors

1 Medical parasitology ,faculty of medicine , Zagazig university ,Zagazig ,Egypt

2 Medical parasitology ,faculty of medicine ,Zagazig university ,Zagazig ,Egypt

3 department of pathology, zagazig university egypt

Abstract

Aim of the work: To evaluate the histopathological alterations and immuno-histochemical pattern in chronic Toxoplasma gondii infection, and to evaluate the role aminoguanidine in experimental toxoplasmosis.

Subjects and methods: This study was carried out on 48 laboratory-bred male Swiss albino mice which were divided into 4 groups (non-infected control; infected control; infected and treated with spiramycin; infected and treated with aminoguanidine). The effect of the used drugs was assessed using parasitological, histopathological and immunohistochemical approaches.

Results: There was highly significant (P

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Zagazig University Medical Journal
Volume 27, Issue 5
September 2021
Pages 938-947

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