The Efficacy of Diphenylcyclopropenone in Treatment of Molluscum Contagiosum

Ibrahim, Samia Ali; Fathy, Marwa Mohamed; Abd Elmoniem, Nesma Elsayed; Ebrahim, Howyda Mohamed

doi:10.21608/zumj.2020.34318.1890

The Efficacy of Diphenylcyclopropenone in Treatment of Molluscum Contagiosum

Document Type : Original Article

Authors

¹ Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

² Department of Dermatology, Venereology and Andrology,Faculty of Medicine, Zagazig University, Zagazig, Egypt,

³ Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig,Egypt,

⁴ Zagazig University Hospital

10.21608/zumj.2020.34318.1890

Abstract

Abstract
Background
Diphenylcyclopropenone (DPCP) contact immunotherapy has been successfully utilized in various forms for treatments of recalcitrant and facial warts, molluscum contagiosum (MC) and alopecia areata.
Objective
The objective was to evaluate the safety and efficacy of DPCP in the treatment of MC.
Patients and Methods
Twenty-four patients with MC were assigned to two groups: twelve patients (group A) were treated with topical application of DPCP one session per week for a maximum of 12 sessions or until clinical cure. Also, twelve patients (group B) were subjected to topical application of normal neutral saline as a control group. Follow-up was done for 3 months.
Results
In group A, eight patients (66.7%) showed complete response while four patients (33.3%) showed partial response to the topical application of DPCP after seven to twelve sessions. However, in group B, eleven patients (91.7%) showed no response and (8.3%) showed partial response. A highly significant difference was found in the clinical response between both groups (p < /p>

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Main Subjects