Evaluation of malondialdehyde in vitiligo patients as a marker of lipid peroxidation

Document Type : Original Article

Authors

1 dermatology

2 52,Al galaa street,zagazig,Sharkia Dermatology Dept, Faculty of Medicine, Zagazig University

3 medical biochemistry department, faculty of medicine, Egypt

4 Dermatology, Venereology and Andrology Department, faculty of Medicine, Zagazig University

Abstract

Abstract:
Background : Vitiligo is a chronic depigmented skin disorder with melanocytes depletion. The pathogenesis of melanocyte damage in vitiligo is still unclear. However, there were some in vivo and in vitro studies that indicate the role of oxidative stress in pathophysiology of vitiligo. Vitiligo is characterized by a blunt increase of ROS and inflammatory mediators, such as cytokines and nitric oxide (NO), contributing to melanocyte dysfunction and/or destruction. Oxidative stress may be a good model for vitiligo pathogenesis . Lipid peroxidation in the cellular membrane of melanocyte may play an important role in depigmentation of vitiligo.
Subject and Methods: The study was conducted on 50 participants: 25 patients with vitiligo and 25 aged matched healthy controls. Malondialdehyde (MDA) was measured spectrophotometerically.
Results: There was highly statistical significant difference between studied groups regarding MDA level ( p ≤0.001).
Conclusions: Oxidative stress may play an important role in the pathogenesis of vitiligo.
Keywords: Vitiligo‚ Oxidative stress‚ Malondialdehyde.

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Zagazig University Medical Journal
Volume 29, Issue 1.2
January 2023
Pages 235-239

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