EVALUATION OF ANGIOPOIETIN-2 AS AN EARLY MARKER FOR DIABETIC NEPHROPATHY INZAGAZIG UNIVERSITY HOSPITALS

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ABSTRACT
Background: To assess the validity of measuring plasma Angiopoietin as a biomarker for early detection of diabetic
nephropathy and todetermine the relation between plasma Ang-2 and inflammation in diabetic nephropathy patients in
Zagazig university Hospitals.
Subjects and methods:This study included a total of 76 diabetic patients divided to microalbuminuria and
macroalbuminuria groups , each group contained 38 patients in addition to 40 healthy control subjects.
Results: Plasma levels of Ang-2 was significantly higher in patients with microalbuminuria and macroalbuminuria
compared to healthy controls. Indeed, Ang-2 levels steadily increases with the progression of albuminuria . The study
showed significant positive correlation between plasma Ang-2 , MAP and creatinine, uric acid, phosphorus, CRP, total
cholesterol and triglycrides . We observed also significant negative correlation between plasma Ang-2 and Hb, eGFR,
serum calcium and albumin.
Conclusion:Our results indicated that Plasma Angiopoietin-2 levels are elevated in patients with diabetic
nephropathy . plasma Ang-2 steadily increase with the progression of albuminuria, suggesting their possible role as early
markers of microvascular angiopathy of glomeruli . Plasma Ang-2 is related to CRP, this implies that elevated levels of
this biomarker occur as a result of inflammation and vascular dysfunction as a part of atherosclerotic process.
Abbreviations: Ang-2 =Angiopoietin-2, CRP = C-reactive protein, Hb= hemoglobin, ACR = albumin-creatinine
ratio, ESRD = end stage renal disease, MAP= mean arterial pressure, FBS = fasting blood suger.



 

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