Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients

Mohamed, Randa Hussiny; Elzaiat, Ahmed Mohamed; Elfeky, Hoda Kamal; Al-Karamany, Amira Saber

doi:10.21608/zumj.2021.42702.1942

Polymorphism of 11 β-Hydroxysteroid Dehydrogenase Type 1 Gene in Hypertensive Patients

Document Type : Original Article

Authors

¹ Medical Biochemistry Faculty of Medicine - Zagazig University ,Zagazig city,Egypt

² Cardiology Faculty of Medicine - Zagazig University, Zagazig city,Egypt

³ Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig city, Egypt

⁴ Medical Biochemistry Faculty of Medicine - Zagazig University,Zagazig city,Egypt

10.21608/zumj.2021.42702.1942

Abstract

Background: Essential hypertension (EH) is the most well-known cardiovascular illness. It is estimated that (30% - 40%) of blood pressure (BP) is caused by genetic factor. Objectives: to investigate the relation between 11 beta hydroxysteroid dehydrogenase type 1) 11β-HSD1 (gene polymorphism and EH in patients attending Zagazig University Hospitals. Methods: Thirty-one patients having EH and the control group of thirty-one apparently healthy individuals. 11β-HSD1 gene polymorphism (rs45487298) was analyzed by restriction fragment length polymorphism reaction. Results: we found that A allele was significantly higher in hypertension (HTN) group and Subjects carrying A allele had a higher incidence to have HTN (OR = 2.5, 95 % CI = 1.04–5.8 and P = 0.04). Levels of TG, and total cholesterol, were signiﬁcantly higher and levels of HDL cholesterol were signiﬁcantly lower in A/A than in wtwt genotype. Also A allele and triglycerides are independent risk factor for EH development. Conclusion: there was a significant relation between 11β-HSD1 gene polymorphism and EH.

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