Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome

ELOSS, ASMAA ABDELHADY; El Saied, Amal Abdelaziz; Abd Elhameid, Azza Abd Elmageid; Mahdy, Entesar Roshdy

doi:10.21608/zumj.2021.59551.2117

Effect of Letrozole versus Clomiphene Citrate on Endometrial Receptivity and Peri follicular Vascularity in Infertile Women with Polycystic Ovarian Syndrome

Document Type : Original Article

Authors

¹ OBSTETRIC &amp; GYNECOLOGY DEPARTMENT FACULTY OF MEDICINE ZAGAZIG UNIVERSITY

² Professor of Obstetrics and Gynaecology, Faculty of Medicine - Zagazig University

³ obstetric& gynecology departement faculty of medicin zagazig university

10.21608/zumj.2021.59551.2117

Abstract

Background: Polycystic ovarian syndrome is the most common endocrine problem in females with an incidence of (6 -10%) . The purpose of this study was to make acomparison between the effect of clomiphene citrate versus letrozole on the endometrial receptivity and perifollicular vascularity among infertile patients having PCOS. Methods: This randomized comparative clinical study was conducted in infertility clinic of laparoscopy&cytogenic unit, Obstetrics and Gynecology department , zagazig university , Egypt from June 2019 to June 2020. It included a total of 54 infertile women diagnosed as having PCOS, 27 women received Clomiphene Citrate 100 mg and 27 patients received letrozole 5mg for ovulation induction. Thickness and pattern of the endometrium , uterine and spiral artery Doppler indices were calculated for 3 subsequent cycles on HCG injection day. Either clomiphene citrate or Letrozole was administrated by mouth for 5 days from day 3 of menstrual cycle . Results: As regards peri follicular vascularity, highly valuable difference was detected between two groups tested on HCG injection day in the 3 subsequent cycles . Ovulation rates were higher in the letrozole group than in the Clomiphene citrate group, but the discrepancy was not statistically valuable , in letrozole (70%, 74%, 81%) and in clomiphene citrate (63.0%, 67%, 77%) in 3 subsequent cycles. Conclusions: Both Clomiphene citrate and letrozole increase perifollicular blood flow with significant difference in favour to letrozole, in letrozole group most of follicles were (grade3) and in Clomiphene citrate group (grade2) .

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