Study of fibroblast growth factor-23 in iron deficiency anemia in group of Egyptian Children

Document Type : Original Article

Authors

1 Department of Pediatrics , Alahrar Teaching Hospital , General organization of Teaching Hospital and Institutes ,Egyptt

2 Fellow of Clinical Pathology ,Benha Teaching Hospital ,General Organization of Institustes and Teaching Hospitals,Egypt

Abstract

Background:
Iron deficiency anemia (IRD) is a common disorder in children in Egypt. In various ages. Fibroblast growth factor 23 (FGF 23) is a hormone produced by osteocytes promotes phosphate excretion, inhibits vitamin D metabolism
Aim of study:
To study the level of FGF-23 in iron deficiency anemia in group of Egyptian children and its relation to bone health and development
Subject and Methods:
The study was conducted on 66 patient diagnosed as IRD . CBC was done. Serum iron, TIBC was measured by spectrophotometer , , calcium phosphorous alkaline phosphatase was measured by VTTos 350. Serum CRP, ferritin, 1,25 OH vitamin D and FGF 23 was done by ELIZA Results:
IRD cases showed higher serum alkaline phosphatase FGF 23 and lower 25 OH vitamin D compared to control It showed negative correlation with serum ferritin ,and Hb in IRD cases. In cases with no signs suggest rickets(BDLR) , no correlation was found with Hb .No relation was found to serum iron or TBIC in both groups. Also, It showed positive correlation with alkaline phosphates with no significant relation in cases with no BDLR .
Conclusion:
FGF 23 is increased in cases with IRD compared to control. Become more evedent in cases with rickets . It showed negative correlation with Hb and serum ferritin and positive correlation with alkaline phosphatase. The relation to Hb and alkaline phosphatase was lost in non rackitic cases

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