Keloids: Epidemiology, Histopathology, Mechanisms and Models of treatment

Document Type : Review Articles

Authors

1 Dermatology and Venereology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt

2 Dermatology and Venerology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

3 Dermatology and Venereology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

Keloid is skin disorder of excess fibrous tissue deposition that usually follow a noxious insult to the skin. Irregular arrangement of connective tissue components together with exaggerated collagen deposition are noticed on histological examination of slides of keloid tissue. The definitive cause is not yet well-known. Diverse array of risk factors including family history and black race are thought to share in the development process. Because of unaccepted cosmetic appearance and negative impact on patient’s quality of life, keloid is widely investigated by many researchers. The treatment panel of keloid include large number of treatment tools. Many substances are available for direct intra-lesional injection such as triamcinolone acetate and botulinum toxin A. Cryotherapy of the keloid can result in occlusion of small vessels and reduce its size. Other modalities of treatment include laser therapy and radiotherapy. Modalities of laser treatment include fractional laser or pulsed dye laser. Laser assisted drug delivery is a recently developed modality. Surgical scar revision is often associated with recurrence

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Zagazig University Medical Journal
Volume 29, Issue 4
July and August 2023
Pages 1013-1017

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