Prediction of fetal growth restriction by ultrasonography and biochemical markers in Zagazig university hospital

Ismail, Anwar; Ali, Ali El-Shabrawy; El-Sayed, Gamal Abbass; Sherif, Mostafa Refaat; Alsowey, Ahmed Mohamed

doi:10.21608/zumj.2022.121060.2475

Prediction of fetal growth restriction by ultrasonography and biochemical markers in Zagazig university hospital

Document Type : Original Article

Authors

¹ Obstetrics and Gynaecology Department, Zagazig University, Zagazig, Egypt

² Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Egypt

³ Radiodiagnosis Department; Faculty of medicine, Zagazig University, Egypt.

10.21608/zumj.2022.121060.2475

Abstract

Objectives: To measure the efficiency of combining clinical, biochemical markers, and doppler studies (uterine and umbilical arteries) as values to predict fetal growth restriction.
Methods:This randomized clinical cross-sectional research has been carried out atthe ultrasound unit in the Department of Obstetrics and Gynecology, and the laboratory unit, Faculty of Medicine, Zagazig University between 2017 to 2021.
Results:124 pregnant women who visited the antenatal clinicatthe Department of Obstetrics and Gynecology with suspected clinical criteria of FGR were included.The incidence of positive FGR in high-risk patients in our study is 24.5 % and negative 75.5%. Abnormalbiochemical markers (PAPPA≤0.42+Homocysteine ≥6.3) were 42.3% sensitive, 88.0% specific and 70.8% accurate in the prediction of FGR. Also, a statistically significant relation between FGR and uterine artery doppler is noted. However,a combination of uterine artery doppler (PI>1.57 + Diastolic notching) and biochemical markers was 46.2% sensitive, 58.8% specific and 55.7% accurate in the prediction of FGR. Finally,there is a highly statistically significant relation between both FGR and umbilical artery Doppler at 29th– 31stweeks.
Conclusion:The incorporated model of screening in this study can be a beneficial method to identify patients at increased risk of FGR. The best finding in this study is a combination of uterine artery and umbilical artery doppler was 88.5% sensitive, 96.3% specific and 94.3% accurate in the prediction of FGR.

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