Updates on toxicology of Aluminum Phosphide and different management protocols

Document Type : Review Articles

Authors

1 Faculty of Medicine, Zagazig University

2 Department of Forensic Medicine and Toxicolgy, Faculty of Medicine, Zagazig University

Abstract

Background: Aluminum phosphide (ALP) is a poisonous chemical used to fumigate stored grains. Despite its severe toxicity, there is no antidote and only supportive measures are used. Aluminum phosphide causes mitochondrial damage and oxidative stress. We want to clarify incidence of ALP-toxicity in Egypt and globally, its consequences on various organs, and therapy options. The medical community must be informed of the increased risk of ALP-toxicity and the additional consequences seen in new patients. We examined PubMed, Cochrane, and Scopus databases to search for all ALP-toxicity consequences and decide the best option to be taken in acute AIP-toxicity and its sequelae. Conclusion: The growing market availability of AIP makes it an easy option for self-harm or perhaps murder. Due to the absence of a precise antidote, affected people die quickly. It's important for the medical staff to be aware of the increasing danger of ALP-toxicity and the new complications observed in the new cases.

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Zagazig University Medical Journal
Volume 28, Issue 6
November 2022
Pages 1176-1183

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