Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer

Document Type : Original Article

Authors

1 Pathology faculty of medicine Zagazig university

2 Pathology department, faculty of medicine, zagazig university, Egypt

3 clinical oncology, faculty of medicine

4 Clinical oncology department

5 Urology department , Zagazig University

6 pathology department,faculty of medicine,zagazig university,Egypt

Abstract

BACKGROUND: Despite advances in intravesical therapy and surgery, up to 30% of NMIBC suffer progression to MIBC.
OBJECTIVES: To identify the valuable prognostic biomarkers, we analyzed the immunohistochemical expression of Sox2, YAP1, and IMP3 in 60 cases of NMIBC who underwent TURBT with adjuvant intravesical bacillus-Calmette-Guerin (BCG).
METHODS: The immunohistochemical expression was done on a sixty patients who complained from primary papillary superficial transitional cell carcinoma (TCC) of the urinary bladder (Stage Ta-T1).Their predicting role for recurrence, progression, progression-free survival (PFS), and recurrence-free survival (RFS) was assessed.
RESULTS: High Sox2 expression was observed in 55% of NMIBC cases, and it was significantly associated with the tumor size, grade, and stage (p < /p>

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Zagazig University Medical Journal
Volume 28, Issue 6
November 2022
Pages 1414-1429

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