The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt

Document Type : Original Article

Authors

1 Medical Biochemistry Department- Faculty of Medicine - Zagazig University

2 Pediatric Department, Faculty of Medicine, Zagazig University

3 Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia Egypt

4 Pediatric Department ,Faculty of Medicine ,Zagazig University

5 Medical Biochmestry Department, Faculty of Medicine, Zagazig Univerisity, Zagazig, Egypt

Abstract

Background: Hypercoagulable state is associated with thalassemic children with increased risk of thromboembolic events ,There are multiple factors are contributing to hypercoagulable state in thalassemia patient.
Aim of the study: To assesses the prothrombin G20210A gene polymorphism in Egyptian thalassemic children being additional risk factor for thromboembolism in thalssemic children .

Methods: This is a case control study. It included 40 thalassemic patients with thromboembolic manifistation and 40 healthy controls. The prothrombin gene polymorphism was identified using a restriction fragment length polymerase chain reaction (RFLP PCR).
Results: No Significant difference in prothrombin G20210A genotype between Thalssemic patient with thrombotic manifistation and controls regarding allele and genotype distributions. (OR 3.2 , 95 % CI 0.57–17.89 and p=0.082 for AA genotype ). A allele was significantly related to cases (25% in cases in comparison to 12.5% in controls).
Conclusion: prothrombin gene polymorphism has no role predisposition to thalassemic coagulability in thalassemic Egyptian children.

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Zagazig University Medical Journal
Volume 30, Issue 2
March and April 2024
Pages 513-521

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