Document Type : Original Article
Authors
1
Clinical Pharmacology- Faculty of Medicine- Zagazig University -Zagazig -Egypt
2
Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt
3
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
4
Clinical Pharmacy Department, Faculty of Pharmacy, Modern University for Technology & Information, Cairo, Egypt.
5
Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, 44519 Egypt.
6
Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Date palm fruit (Phoenix dactylifera L.) can be used as a pharmaceutical product because of its rich phytochemical composition. Mobile phone radiation is a type of electromagnetic radiation (EMR) that has been confirmed to exert several adverse effects on living tissues. Methods: In this study, we investigated the phytochemicals of the Egyptian date palm fruit using ultra-performance liquid chromatography with electrospray ionization quadrupole- linear ion trap tandem mass spectrometry analysis (UPLC-ESI-MS/MS) in negative and positive ionization modes. Adult male Wister albino rats were exposed to mobile phone induced electromagnetic radiations (EMR) for 1 hour per day for 4 weeks. We evaluated the possible cytoprotective effects of date palm fruits compared with vitamin C on mobile phone induced EMR. Rats were divided into the control, EMR, and two EMR groups treated with either vitamin C or date palm fruit. Results: The analysis of date resulted in the tentative identification of 29 compounds, including 13 free organic acids and their derivatives, 9 flavonoids and their glycosides, 3 fatty acids, and 4 miscellaneous compounds. Both biochemical and histopathological examinations of adrenal tissues confirmed that mobile phone radiation caused significant increases in oxidative stress, DNA damage, inflammatory marker levels, fibrosis, and apoptosis in adrenal tissues compared with the control group. Both vitamin C and date palm fruit significantly reduced these damaging effects with superior cytoprotective effect for date palm fruit over vitamin C. Conclusion: Date palm fruits could protect the adrenal glands due to its antiapoptotic, antioxidant, antifibrotic and anti-inflammatory properties.
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