A comparative study of Ozonized olive oil versus Tazarotene gel in the Treatment of Onychomycosis

Document Type : Original Article

Authors

1 dermatology &venereology department, faculty of medicine, Zagazig university

2 dermatology ;venereology department, faculty of medicine, Zagazig university

Abstract

Background
Onychomycosis is a fungal infection of the nail bed that may end in nail dystrophy. Topical ozonized oil was reported to have antifungal effects. It delivers oxygen that kill fungus and bacteria. Tazarotene has anti-inflammatory and immune-modulating activities.
Objective
Evaluate the efficacy and safety of topical ozonized olive oils compared to topical tazarotene in patients with onychomycosis
Patients and Methods
This study included 32patients with onychomycosis. Patients were assigned into two groups; group I treated topically with ozonized oil, group II applied topical 0.1% tazarotene gel. Both medications were applied for 3 months. Patients were followed up for 6 months. Assessment was based on clinical and mycological evaluation by analysis of the culture taken before and after treatment.
Results
The mycological clearance at the end of treatment (12 weeks) occurred in 12 patients (75%) in group 1(ozonized oil) compared to 9 patients (56.25%) in group2 (tazarotene) (p < 0.03). There was a significant improvement of all clinical parameters of the affected nails in both groups (P

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Zagazig University Medical Journal
Volume 30, Issue 2
March and April 2024
Pages 474-481

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