Diacerein protects against renal ischemia/reperfusion-induced kidney and lung injuries: involvement of osteopontin and Nrf-2/HO-1 pathway.

Document Type : Original Article

Authors

1 Clinical Pharmacology department, faculty of medicine, zagazig University, Egypt

2 Clinical Pharmacology Department, Faculty of Medicine, Zagazig, University, Egypt

3 Clinical pharmacology department, Faculty of Medicine, Zagazig University, Egypt

Abstract

Background: Renal ischemia/reperfusion is an imperative cause of acute kidney damage which in turn releases detrimental mediators into the circulation leading to subsequent remote organ injury. The current study attempted to assess the possible protective effects of diacerein (DIA), an interleukin-1 receptor antagonist, against renal ischemia/reperfusion (I/R) induced kidney and lung injuries in male albino rats.
Methods: Rats were randomly assigned into: sham, I/R, and DIA-pretreated I/R groups. DIA was orally administered in doses of 25, 50 and 100 mg/kg/day for 20 days, then, both right and left renal pedicles were clamped for 45 min followed by reperfusion for 24 h. One-way ANOVA followed by Post-Hoc test were used to compare the results. P-Value of

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Zagazig University Medical Journal
Volume 30, Issue 1
January and February 2024
Pages 14-23

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