Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma

Alqurashi, Lobna A.; Mohamed, Hoda Fathi; El-Gebaly, Ahmed M.; El-Akabawy, Nadia M.; Samra, Saad R.; Zake, Lamiaa Gaber

doi:10.21608/zumj.2022.159017.2631

Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma

Document Type : Original Article

Authors

¹ Medical micro biology and immunology Department, Faculty of medicine, Zagazig University, Zagazig, Egypt

² faculty of medicine zagazig university clinical pathology department

³ Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt

⁴ Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

⁵ Chest department, Faculty of medicine, Zagazig University, Zagazig, Egypt

⁶ Department of Chest diseases, Faculty of Medicine, Zagazig University, Egypt

10.21608/zumj.2022.159017.2631

Abstract

Abstract
Background: Type 2 innate lymphoid cells (ILC2s) are introduced as a key player in type 2 inflammation. Objectives: To assess the correlation between ILC2s in peripheral blood, sputum, and colonic biopsies among patients with asthma, and to assess the relation between ILC2s frequency and severity of asthma. Methods: ILC2s numbers were assessed in peripheral blood, and sputum among 29 patients with asthma (asthma group) and 29 healthy controls (control group). Colonic biopsies were obtained from twelve mild to moderate asthma patients and nine healthy controls. ILC2s were determined by multicolor flow cytometer in all specimens. Results: ILC2s numbers in peripheral blood were higher among the asthma group compared to the control group (P

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