Document Type : Original Article
Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Background &Aim : Ankylosing spondylitis (AS) is a chronic inflammatory condition that affects the sacroiliac, and peripheral joints. Systolic dysfunction in AS by conventional assessment may not detect early impairment, so we aimed to assess two-dimensional (2D)-speckle tracking echocardiography (STE) on the left ventricle (LV) and right ventricle (RV) and correlate these findings with AS disease activity score (ASDAS-CRP). Methodos: A case-control study involving 135 participants; they were classified into three groups, inactive group (I) 57 cases, active group (II) 33 cases, and 45 control group (III) . The (ASDAS-CRP) score was calculated for all patients. Laboratory parameters ;c–reactive protein (CRP), and lipid profile , conventional echocardiographic assessment of ventricular systolic function and (2D) (STE) on both (LV) and (RV) were done. Results: (ASDAS-CRP) score was high in the the active group (II) with a p-value <0.001. Right ventricular free wall strain (RVFWS) was more impaired in the same group p-value <0.001. Pulmonary artery systolic pressure (PASP) was also high in the same group p-value <0.001. AS population was divided into 2 subgroups according to drug type biological 70 cases versus non-biological 20 cases. RVFWS was more impaired in the biological drug group (-18.35%±3.08 versus -20.76±2.21 in the non-biological group, p-value 0.002. The predictor of impaired RVFWS in AS was PASP (p= 0.001), Exp (B) 1.143, 95% C.I: (6.895 to 13.714). RVFWS had a significant negative correlation with (ASDAS-CRP), disease duration, and PASP Conclusion: Impaired RVFWS was detected in patients with AS and was associated high disease activity score.