Clinicopathological Impact of CPA4, UHRF1, Glypican-1, and CD90 Expression in Lung Adenocarcinoma and Epithelioid Malignant Mesothelioma

Abdelrahman, Doaa I.; Elfeky, Mariem A.; El Mosely, Marwa M.; Mandour, Doaa; Abozaid, Mohamed M.; Hemeda, Rehab

doi:10.21608/zumj.2024.270576.3175

Clinicopathological Impact of CPA4, UHRF1, Glypican-1, and CD90 Expression in Lung Adenocarcinoma and Epithelioid Malignant Mesothelioma

Document Type : Original Article

Authors

¹ Lecturer of Pathology, Zagazig University, Zagazig, Egypt

² associate professor of pathology, Zagazig university, Egypt.

³ Lecturer of Pathology, Zagazig University, Egypt

⁴ associate professor of Clinical oncology and Nuclear Medicine, Zagazig University, Egypt

⁵ associate professor of Chest, Zagazig University, Egypt

⁶ associate professor of clinical oncology and nuclear medicine, faculty of medicine, Zagazig university, Egypt

10.21608/zumj.2024.270576.3175

Abstract

background: Accurate diagnosis, early detection, and differentiation of lung adenocarcinoma from mesothelioma; particularly the epithelioid subtype is needed to allow better management thus to improve their prognosis.

Aim of our study was to assess applicability of CPA4, UHRF1, glypican-1 and CD90 expression by immunohistochemistry to differentiate between lung adenocarcinoma and epithelioid mesothelioma in addition to detection of their prognostic roles and relation to patients’ survival.

Methods: We collected samples from 30 patients diagnosed with lung adenocarcinoma and 30 patients diagnosed with epithelioid mesothelioma. For the immunohistochemistry, sections of all collected samples were incubated with CPA4, UHRF1, glypican-1 and CD90 to assess their diagnostic accuracy.

RESULTS: A highly significant association was detected between positive CPA4, UHRF1 expression in lung adenocarcinoma and their diagnostic accuracy (p value <0.001). Also, highly significant association was detected between positive CD90, Glypican 1 expression in epithelioid mesothelioma and their diagnostic accuracy (p value <0.001). CPA4 expression was associated with shorter OS rate (P value 0.019, 0.009) UHRF1 expression was associated with shorter OS rate (P value=0.009)

Conclusions: CPA4, UHRF1, glypican-1 and CD90 were considered novel biomarkers that have important roles in differentiation between epithelioid malignant mesothelioma and adenocarcinoma of the lung with high sensitivity and specificity.

Keywords