Document Type : Original Article
Authors
1
Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt
2
Pediatric Department, Faculty of Medicine, Zagazig University
3
Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Children who have chronic kidney disease (CKD) or end-stage renal disease (ESRD) often present with a range of concurrent medical conditions, one of which is dyslipidemia. This work aimed to detect the frequency of dyslipidemia among children with ESRD at Zagazig university hospitals.
Methods: This cross-sectional observational study included 61 children patients) aged from 4 to 17 years old, who had ESRD (CKD grade V) with estimated glomerular filtration rate less than 15 ml/min/1.73m2 by modified Schwartz equation and on regular hemodialysis. A comprehensive history taking, thorough physical examination, and laboratory tests, including regular labs and the lipid profile, were conducted for all patients.
Results: High percentage of examined children had high lipid profile (29.5 %) of the populations, The prevalence of abnormally high levels of total serum cholesterol, triglycerides, and low-density were found to be 29.5%, 75.4% and 16.4% respectively. Triglycerides, VLDL-C, and HDL levels were found to be higher during maintenance hemodialysis. No significant correlation was found between duration of hemodialysis, urea, and creatinine, with Cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein, and very low-density lipoprotein, except for a significant positive correlation between phosphate (Po4) and high density lipoprotein (HDL) (P =0.022).
Conclusion: The prevalence of dyslipidemia was found to be high among HD patients in Zagazig university hospitals. Comparisons of lipid parameters with CVD risk stratifications need further studies to prove the benefits of these scores in CVD prediction among the dialysis population.
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