Assessment of outcome of Ovarian Cancer Treatment; Retrospective cohort study

Mohammed, Shimaa Shabaan Fathy; Soliman, Mohammed Abdelgawad; Abdelaziz, Lobna Abdelaziz; Mandour, Doaa Abdelrahman

doi:10.21608/zumj.2024.296290.3437

Assessment of outcome of Ovarian Cancer Treatment; Retrospective cohort study

Document Type : Original Article

Authors

¹ Clinical Oncology & Nuclear Medicine Department, Faculty of Medicine, Zagazig university

² Clinical Oncology & Nuclear Medicine Department, Faculty of Medicine, Zagazig university

10.21608/zumj.2024.296290.3437

Abstract

Background: When it comes to women with malignant gynecological tumor diagnosis, ovarian cancer (OC) is the most prevalent cause of death. Generally, it ranks as the fifth most common cause of mortality for females

Objectives: The present study aimed to study the epidemiological characteristics and treatment outcomes of OC cases in the Clinical Oncology and Nuclear Medicine Department at Zagazig University Hospitals.

Subjects and methods: This retrospective cohort study targeted seven years from January 2015 to December 2021 and was conducted on 160 medical files of patients with OC from the Clinical Oncology and Nuclear Medicine Department, Zagazig University hospitals. The data of pathological and epidemiological characters and their outcomes were studied.

Results: 66.9% of the studied patients had surgery upfront. The most frequent surgery types were TAH+BSO+Surgical staging (38.3%), TAH+BSO (29.4%), and Fertility-sparing surgery was reported in 7.9% of the cases. Regarding primary chemotherapy (95.6%) of patients had Primary chemotherapy as follows (2.5%) Neoadjuvant treatment only, (45%) Adjuvant only, (23.7%) had neoadjuvant and adjuvant, (4.4%) Definitive, and (20%) Palliative treatment. Regarding Hormonal treatment ; (6.9%) of patients had Hormonal treatment as follows (1.9%) Adjuvant, (1.3%) Definitive, and (3.7%) salvage for Recurrence.

Conclusion: This study demonstrates age as an important epidemiological factor, histopathological assessment, surgical status, radiological, location, grading, tumor morphology, treatment, outcome, recurrence of tumor, disease-free survival, and overall survival that was collected from patient archives in Clinical Oncology and nuclear medicine department in Zagazig University Hospitals. Therefore, this data can provide preliminary information for upcoming research.

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