Serum Biomarkers Predicting Prognosis of Spontaneous Intracerebral Hemorrhage

Document Type : Original Article

Authors

1 Neurology Department, Faculty of Medicine, Zagazig University

2 Neurology department, Faculty of Medicine, Zagazig University

Abstract

Background: Intracranial hemorrhage (ICH) carries a high risk for mortality and morbidity. Identification of reliable predictors of outcome are important to optimize treatment. The Aim of our study was to identify the impact of platelet count and volume; neutrophil /platelet ratio (NPR) and LDL cholesterol (LDL-C) at admission on the short term clinical outcome of ICH. Subject and Methods: A total of 138 adult patients with definite diagnosis of ICH were recruited to this study. The clinical characteristics and the previously mentioned laboratory markers were assessed and correlated with the short term outcome determined by the modified Rankin Scale (mRS) after one month of onset. Results: No significance was observed between platelet count and volume; NPR, and poor prognosis of stroke. Hypertension, high National Institute of Health Stroke Scale (NIHSS) score on admission were significantly related to bad prognosis (P = 0.045, 0.01 respectively); in addition to higher levels of INR and lower levels of LDL-C (P = 0.02 and .002 respectively). Conclusion: Poor outcome after ICH was related to severity at onset assessed by NIHSS. Hypertension, bleeding tendency and lower LDL-C levels were also independent factors for poor outcome.

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Zagazig University Medical Journal
Volume 30, Issue 7
October 2024
Pages 3298-3307

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