Could Hematological parameters reflect inflammatory and nutritional state among dialysis patient?

Abdelmoneem, Shimaa; Arafa, Ayman Fathy; Shoieb, Maha Elsaeed Abbas; Easa, Manal Mohamed; Metwally, Elsayed Anany

doi:10.21608/zumj.2024.310741.3509

Could Hematological parameters reflect inflammatory and nutritional state among dialysis patient?

Document Type : Review Articles

Authors

¹ lecturer of Internal medicine, Clinical Hematology Unit, Faculty of Medicine,Zagazig University

² Professor of Internal medicine,Clinical Hematology Unit, Faculty of Medicine, Zagazig University

³ Resident of internal medicine, Damas Central Hospital

⁴ lecturer of Clinical pathology, Faculty of Medicine, Zagazig University

⁵ lecturer of Internal medicine, Clinical Hematology Unit, Faculty of Medicine, Zagazig University

10.21608/zumj.2024.310741.3509

Abstract

Background: When kidney function is consistently impaired, as in the case of chronic kidney disease (CKD) or chronic renal failure (CRF) or, diagnostic criteria include an unusually high blood creatinine level for longer than 3 months or the glomerular filtration rate (GFR) to be below 60 ml/min / 1.73 m2. Loss of energy stores and body proteins is one indicator of a worsening nutritional condition in patients with poorly controlled chronic renal disease, especially in its latter stages. Cases who had end-stage kidney disease (ESKD) are already fragile due to muscular atrophy, sarcopenia, and cachexia; furthermore, malnutrition is a powerful predictor of illness and death in this population. We intended to provide an outline of hematological parameters that could reflect inflammatory and nutritional state in dialysis patient.

Conclusion: Cytokines like interleukin-6 (IL-6), interleukin-1 (IL-1), or tumor necrosis factor (TNF), gastric mediators like ghrelin as well as leptin, and adipokines may all play a role in mediating the anorexic process. More research into the identification and prevention of malnutrition, in particular, is necessary due to the complicated interaction between inflammatory and nutritional parameters during chronic kidney disease (CKD). We require additional studies on these mediators

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