Document Type : Original Article
Authors
1
Rheumatology and rehabilitation faculty of medicine Zagazig University
2
Clinical pathology department, faculty of medicine, zagazig university, sharkia
3
Lecturer of Rheumatology and Rehabiitation, Zagazig University.
Abstract
Abstract
Background
Red blood cells (RBCs) and platelets have been linked to inflammation in various rheumatological illnesses. As a result, the purpose of the current research was to investigate the association between each of the RBC- and platelet-related parameters and disease activity in JIA patients, as well as to compare these indices between JIA patients and normal children.
Methods
A case-control study included 88 subjects, 44 in each group (JIA & control). The variations in platelet indices between normal and JIA children were documented. The associations between CBC-related parameters and disease activity, disease subtype, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were determined.
Results
JIA patients had significantly higher hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), platelets (PCT), HB to platelets (HPR), mean corpuscular hemoglobin (MCH) platelets count, platelets to lymphocytes ratio (PLR) & WBC count and lower mean platelet volume (MPV), RBCs to platelet ratio (RPR), and compared to healthy children (P <0.05).
Active JIA patients exhibited significantly lower levels of MPV, Hb, MCH, RPR, and HPR and significantly higher platelets than inactive JIA patients’ children (P <0.05).
Both CRP & ESR levels showed significant negative correlations with MCHC, hemoglobin levels, MCH, RPR, and HPR in JIA patients (P<0.05). Meanwhile, ESR levels revealed a strong positive correlation with platelet count and PCT, and CRP levels revealed a strong positive correlation with platelet count only.
Keywords
Main Subjects
)
View on SCiNiTO