Role of Biofilm Forming Staphylococcus aureus in Urinary Tract Infection

Document Type : Review Articles

Authors

1 Medical Microbiology & Immunology Department, Faculty of Medicine, Zagazig University

2 Medical Microbiology & Immunology Department, Faculty of Medicine, Zagazig University

Abstract

Background: Urinary tract infections (UTIs) are a widespread and recurring health issue that is increasingly becoming a public health concern worldwide. Each year, approximately 150 million people experience UTIs, with over half of the population reporting having had at least one UTI in their lifetime, making it one of the most prevalent bacterial infections globally. One of the main bacterial problems facing public health today is Staphylococcus aureus (S. aureus), which is most common in those suffering from urinary tract infections. While S. aureus has been linked to 0.5–6% of urinary tract infections, untreated S. aureus infections can result in serious, perhaps fatal conditions. Aim of this review article: The aim of this review is to examine how biofilm-forming S. aureus contributes to the pathogenesis of UTIs and its role in antibiotic resistance and recurrent infections. The review focuses on the mechanisms by which S. aureus biofilms exacerbate the persistence and severity of UTIs, especially in the context of multi-drug resistant strains, highlighting the challenges in treating catheter-associated urinary tract infections (CAUTI) and chronic bacterial prostatitis. Conclusion: In fact, because of its multi-drug resistant (MDR) forms, S. aureus has grown to be a global health concern. A significant contributing factor to recurrent urinary tract infections with increased resistance to antibiotics is the biofilm of S. aureus.

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Zagazig University Medical Journal
Volume 30, Issue 8
November 2024
Pages 4464-4475

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